scholarly journals Mycoplasma pneumoniae and Bronchiolitis Obliterans: How a Common Organism Leads to a Rare Pulmonary Disease in Pediatrics

Cureus ◽  
2021 ◽  
Author(s):  
Antonella Jimenez ◽  
Wilfredo De Jesús-Rojas
Keyword(s):  
Pulmonary Disease ◽  
Mycoplasma Pneumoniae ◽  
Bronchiolitis Obliterans ◽  
Common Organism

scholarly journals Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chengsong Zhao ◽  
Jinrong Liu ◽  
Haiming Yang ◽  
Li Xiang ◽  
Shunying Zhao
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Bronchiolitis Obliterans ◽  
Acute Bronchiolitis

scholarly journals Significant Role of Interleukin-8 in Pathogenesis of Pulmonary Disease Due to Mycoplasma pneumoniaeInfection

2001 ◽  
Vol 8 (5) ◽  
pp. 1028-1030 ◽  
Author(s):  
Mitsuo Narita ◽  
Hiroshi Tanaka ◽  
Satoshi Yamada ◽  
Shosaku Abe ◽  
Tadashi Ariga ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Pulmonary Disease ◽  
Pleural Fluid ◽  
Mycoplasma Pneumoniae ◽  
Significant Role ◽  
Critical Role ◽  
Interleukin 8 ◽  
Fibrotic Change

ABSTRACT We found elevated levels of interleukin-8 in pleural fluid samples from patients with pleural effusion and with a sustained fibrotic change of the lung due to Mycoplasma pneumoniaeinfection. This result suggests a critical role of interleukin-8 in the pathogenesis of a certain type of pulmonary disease caused by M. pneumoniae.

scholarly journals Mycoplasma pneumoniae Induces Chronic Respiratory Infection, Airway Hyperreactivity, and Pulmonary Inflammation: a Murine Model of Infection-Associated Chronic Reactive Airway Disease

2002 ◽  
Vol 70 (2) ◽  
pp. 649-654 ◽  
Author(s):  
Robert D. Hardy ◽  
Hasan S. Jafri ◽  
Kurt Olsen ◽  
Jeanine Hatfield ◽  
Janie Iglehart ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Pulmonary Disease ◽  
Mycoplasma Pneumoniae ◽  
Respiratory Infection ◽  
Murine Model ◽  
Pulmonary Inflammation ◽  
Lavage Fluid ◽  
Airway Hyperreactivity ◽  
Whole Body ◽  
Chronic Respiratory Infection

ABSTRACT Because chronic Mycoplasma pneumoniae respiratory infection is hypothesized to play a role in asthma, the potential of M. pneumoniae to establish chronic respiratory infection with associated pulmonary disease was investigated in a murine model. BALB/c mice were intranasally inoculated once with M. pneumoniae and examined at 109, 150, 245, 368, and 530 days postinoculation. M. pneumoniae was detected in bronchoalveolar lavage fluid by culture or PCR in 70 and 22% of mice at 109 and 530 days postinoculation, respectively. Lung histopathology was normal up to 368 days postinoculation. At 530 days, however, 78% of the mice inoculated with M. pneumoniae demonstrated abnormal histopathology characterized by peribronchial and perivascular mononuclear infiltrates. A mean histopathologic score (HPS) at 530 days of 5.1 was significantly greater (P < 0.01) than that for controls (HPS score of 0). Serum anti-M. pneumoniae immunoglobulin G was detectable in all of the mice inoculated with M. pneumoniae and was inversely correlated with HPS (r = −0.95, P = 0.01) at 530 days postinoculation. Unrestrained whole-body plethysmography measurement of enhanced pause revealed significantly elevated airway methacholine reactivity in M. pneumoniae-inoculated mice compared with that in controls at 245 days (P = 0.03) and increased airway obstruction at 530 days (P = 0.01). Murine M. pneumoniae respiratory infection can lead to chronic pulmonary disease characterized by airway hyperreactivity, airway obstruction, and histologic inflammation.

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