scholarly journals Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review

Cureus ◽  
2021 ◽  
Author(s):  
Manusha Thapa Magar ◽  
Sunam Kafle ◽  
Arisa Poudel ◽  
Priyanka Patel ◽  
Ivan Cancarevic
Keyword(s):  
Systematic Review ◽  
Mycobacterium Tuberculosis ◽  
Takayasu’S Arteritis ◽  
Takayasu's Arteritis

scholarly journals Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovisin the aortic tissue of patients with Takayasu’s arteritis

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
María Elena Soto ◽  
Ma Del Carmen Ávila-Casado ◽  
Claudia Huesca-Gómez ◽  
Gilberto Vargas Alarcon ◽  
Vicente Castrejon ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Takayasu’S Arteritis ◽  
Aortic Tissue ◽  
Takayasu's Arteritis ◽  
Gene Sequences

scholarly journals Mycobacterium tuberculosis in the aorta of a patient with takayasu’s arteritis. extra pulmonary tuberculosis

Health ◽  
2011 ◽  
Vol 03 (03) ◽  
pp. 159-161 ◽  
Author(s):  
María Elena Soto ◽  
Virgilia Soto ◽  
Julia Isela Martín Sandría ◽  
Ricardo Gamboa ◽  
Claudia Huesca
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Takayasu’S Arteritis ◽  
Takayasu's Arteritis ◽  
Extra Pulmonary Tuberculosis ◽  
Extra Pulmonary

scholarly journals Therapeutic Management of Ocular Ischemia in Takayasu’s Arteritis: A Case-Based Systematic Review

2022 ◽  
Vol 12 ◽  
Author(s):  
Yue Zeng ◽  
Jianan Duan ◽  
Ge Ge ◽  
Meixia Zhang
Keyword(s):  
Systematic Review ◽  
Medical Therapy ◽  
Vision Loss ◽  
Takayasu’S Arteritis ◽  
Therapeutic Management ◽  
Surgical Approaches ◽  
Takayasu's Arteritis ◽  
Oral Steroids ◽  
Case Based

BackgroundTakayasu’s arteritis (TA) is a rare, chronic granulomatous large-vessel vasculitis that can lead to ocular ischemia. Ocular outcomes after therapeutic management in TA remain largely unknown. We herein conduct a case-based systematic review to address the current treatment options in this particular cohort.MethodsPubMed, Medline, and EMBASE databases were searched pertaining to ocular outcomes after systemic treatment in TA. Studies reporting ocular examinations before and after treatment in TA patients with ocular ischemia were included. Clinical characteristics, therapies, ocular outcomes, and complications were recorded.ResultsA 29-year-old woman with newly diagnosed TA showed dramatic regression of Takayasu’s retinopathy (TR) following balloon angioplasty. Optical coherence tomography angiography (OCTA) was used as a novel strategy for subsequent follow-up. A total of 117 eyes of 66 patients with a median age of 27 years were included for systematic review. TR was the most common ocular manifestation. Oral steroids were prescribed in nearly all patients (n = 65), followed by the use of methotrexate and antiplatelet therapy. Of the patients, 65.8% and 34.2% underwent open surgery and endovascular procedure, respectively. The median follow-up period was 12 weeks (interquartile range 8–33.5). Surgical therapy showed better ocular improvement (including visual and imaging responses) in both acute and chronic vision loss, along with fewer complications than medical therapy alone. In the surgical group, the visual prognosis was significantly better in patients with initial visual acuity better than 20/200 (p = 0.03) and those who underwent surgery before stage III TR (p = 0.01). Ocular outcomes were equivalent in the two surgical approaches.ConclusionClinicians should be familiar with ophthalmic manifestations of this potentially treatable complication in TA. Compared with medical therapy alone, surgical intervention might be a better choice for both acute and chronic vision loss. Surgery is best recommended before the onset of irreversible ischemia to the globe. A combined regimen (oral steroids, immunosuppressants, and antiplatelet drugs) might be effective for those with surgical contradictions or reluctance to an invasive procedure. Physicians should be aware of the importance of ocular examinations, including OCTA, during the diagnosis and follow-up in TA.

scholarly journals THU0594 A CASE OF TAKAYASU’S ARTERITIS IN A PATIENT WITH TUBERCULOUS LYMPHADENITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 539.3-539
Author(s):  
T. Khan ◽  
N. Cleaton ◽  
T. Sheeran
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Heat Shock ◽  
Upper Limb ◽  
Takayasu Arteritis ◽  
Takayasu’S Arteritis ◽  
Tuberculous Lymphadenitis ◽  
Takayasu's Arteritis ◽  
Cervical Lymph Nodes ◽  
History Of ◽  
The Relationship

Background:Takayasu’s arteritis (TA) is a large vessel vasculitis that principally affects the aorta and its main branches. The incidence has been reported at between 1.2 – 2.3 cases per million per year, more commonly in the Asian population. The age of onset is typically between tenth and fourth decade; between 80 and 90 percent of the cases are female.The relationship between Mycobacterium Tuberculosis (mTB) and TA has long been considered; both demonstrate chronic inflammatory changes on histological examination and some granuloma formation in arterial walls. There is increasing evidence implicating mTB in the pathogenesis of TA through molecular mimicry between the mycobacterium heat shock protein -65 (mHSP-65) and the human homologue HSP -60 (hHSP-60). However, no definitive link between the two diseases has been explained.Objectives:Case presentation.Results:A 23-year-old lady was referred to our outpatient rheumatology clinic with a twelve-month history of persistently enlarged cervical lymph nodes on the left side for which she had received six months of anti-Tuberculosis medication. She had been referred to the respiratory physicians who had diagnosed presumed Tuberculous Lymphadenitis, with caseating granulomas demonstrated on biopsy, positive acid-fast bacilli smear but a negative culture. The patient had been initiated six months of anti-Tuberculosis medication; however, her lymphadenopathy showed no improvement. More recently she described a five-month history of weakness, paraesthesia and claudication symptoms in her left upper limb with episodes of dizziness and blurred vision, episodes occurring 2-3 times per day and lasting between a few minutes to a few hours.Her examination at this presentation revealed an unrecordable blood pressure in the left upper limb and 104/67mmHg in the right. There was significant tender lymphadenopathy of the left cervical lymph nodes and diminished pulses in the left upper limb. Right sided pulses were normal. The rest of her examination was normal.Investigations at presentation revealed elevated inflammatory markers with C- reactive protein (CRP) of 116mg/dL and erythrocyte sedimentation rate (ESR) of 128mm/h. Complete blood count (CBC) found her to be anaemic with a haemoglobin of 100g/L, with a mean cell volume of 71.3fl, and have elevated platelet count of 649x 109/L. Recent computerized tomography scan with contrast of the thorax demonstrated features consistent with Takayasu Arteritis. Marked left subclavian stenosis was found on magnetic resonance imaging. High dose prednisolone at 60mg once daily along with Azathioprine 2mg/kg/day was started with a follow up appointment in two weeks.Conclusion:There is increasing evidence implicating mTB in the development of TA and a few cases recognising this link have been reported. We report a case of TA in a patient recently diagnosed and treated for Tuberculous lymphadenitis who then developed symptoms of TA. There should be a low threshold for suspecting a diagnosis of Takayasu’s arteritis in patients previously or actively infected with Mycobacterium Tuberculosis. Further research exploring the relationship between mTB and TA is required.References:[1]Espinoza JL, Ai S, Matsumura I. New Insights on the Pathogenesis of Takayasu Arteritis: Revisiting the Microbial Theory. Pathogens. 2018;7(3):73.[2]Aggarwal A, Chag M, Sinha N, et al. Takayasu’s arteritis: role of Mycobacterium tuberculosis and its 65 kDa heat shock protein. International Journal of Cardiology. 1996; 55: 49–55.[3]Reshkova V, Kalinova D, Rashkov R. Takayasu’s Arteritis associated with Tuberculosis Infections. Journal of Neurology and Neuroscience. 2016; 3:114.[4]Moritz K, Jansson Hilte F, Antje Kangowski, Christian Kneitz, Emil C. Reisinger. Tuberculosis and Takayasu arteritis: case-based review Rheumatology International 2019 39:345–351[5]D Misra, A Wakhlu, V Agarwal, D Danda. Recent advances in the management of Takayasu arteritis International Journal of Rheumatic Diseases 2019; 22: 60–68Disclosure of Interests:None declared

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