An Infant With Seborrhoeic Dermatitis and Eczema Herpeticum Complicated by a Generalized Infection

Eczema herpeticum is an uncommon complication of atopic dermatitis, but often has a typical recognisable appearance. This report serves to highlight this feature in a patient who was misdiagnosed initially with a bacterial skin infection and then with a severe cutaneous drug reaction.

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Ciclopiroxolamine Cream 1% in the Treatment of Seborrhoeic Dermatitis

Clinical Drug Investigation ◽

10.2165/00044011-200222030-00003 ◽

2002 ◽

Vol 22 (3) ◽

pp. 167-172 ◽

Cited By ~ 4

Author(s):

A. Unholzer ◽

S. Schinzel ◽

K.-H. Nietsch ◽

G.E. Jung ◽

Hans Christian Korting

Keyword(s):

Seborrhoeic Dermatitis

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Differences between intrafollicular microorganism profiles in perioral and seborrhoeic dermatitis

Clinical and Experimental Dermatology ◽

10.1046/j.1365-2230.2003.01349.x ◽

2003 ◽

Vol 28 (5) ◽

pp. 531-534 ◽

Cited By ~ 20

Author(s):

H. Takiwaki ◽

H. Tsuda ◽

S. Arase ◽

H. Takeichi

Keyword(s):

Seborrhoeic Dermatitis

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Molecular pathogenesis and clinical implications of eczema herpeticum

Expert Reviews in Molecular Medicine ◽

10.1017/s1462399408000756 ◽

2008 ◽

Vol 10 ◽

Cited By ~ 27

Author(s):

Caroline Bussmann ◽

Wen-Ming Peng ◽

Thomas Bieber ◽

Natalija Novak

Keyword(s):

Atopic Dermatitis ◽

Age Of Onset ◽

Current Knowledge ◽

Allergen Challenge ◽

Skin Lesions ◽

Molecular Pathogenesis ◽

Type I Interferons ◽

Total Serum ◽

Type I ◽

Eczema Herpeticum

A subgroup of patients with atopic dermatitis develops one or more episodes of a severe viral skin infection caused by herpes simplex virus superimposed on eczematous skin lesions. This condition is named atopic dermatitis complicated by eczema herpeticum. Characteristic features of patients developing eczema herpeticum include an early age of onset of atopic dermatitis with a persistent and severe course into adulthood, predilection for eczematous skin lesions in the head and neck area, elevated total serum IgE levels and increased allergen sensitisation. Deficiencies at the level of both the innate and the adaptive immune system, which have been identified in atopic dermatitis, are much more pronounced in this subgroup. Predisposing cellular factors include a reduced number of plasmacytoid dendritic cells in the epidermis and a modified capacity of these cells to produce type I interferons after allergen challenge. In addition, lower levels of antimicrobial peptides in the skin of atopic dermatitis patients, resulting in part from a Th2-prone micromilieu, contribute to the lack of an effective defence against viral attack. In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum.

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