scholarly journals Tall Cell Carcinoma With Reversed Polarity of the Breast

Cureus ◽  
2021 ◽  
Author(s):  
Gustavo Matute ◽  
Linda Barcenas ◽  
Carolina Bautista ◽  
Carlos Alberto Restrepo Ramirez ◽  
Nestor Llinas Quintero
Keyword(s):  
Cell Carcinoma ◽  
Tall Cell ◽  
Reversed Polarity

Tall cell carcinoma with reversed polarity: A case report of a very rare breast tumor entity and mini‐review

2021 ◽  
Vol 27 (4) ◽  
pp. 369-376
Author(s):  
Helen J. Trihia ◽  
Pavlos Lampropoulos ◽  
Loukas Karelis ◽  
Efthymia Souka ◽  
Georgios Galanopoulos ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Breast Tumor ◽  
Tall Cell ◽  
Tumor Entity ◽  
Reversed Polarity

scholarly journals Breast tall cell carcinoma with reversed polarity with an unusual molecular profile

2020 ◽  
Vol 7 (1) ◽  
pp. 46
Author(s):  
Kaitlyn J Nielson ◽  
Edgar G. Fischer ◽  
Jacklyn Jacklyn Nemunaitis ◽  
Sangeetha Prabhakaran ◽  
Nadja K. Falk
Keyword(s):  
Gene Expression ◽  
High Risk ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Molecular Analysis ◽  
Molecular Profile ◽  
Published Data ◽  
Low Grade ◽  
Tall Cell ◽  
Reversed Polarity

Breast tall cell carcinoma with reversed polarity (TCCRP) is rare and previously referred to as solid papillary carcinoma with reverse polarity.  This low grade tumor commonly exhibits IDH2 p.Arg172 mutation, however is not completely understood at the molecular level.  We present a case of TCCRP in a 55 year old woman with a 0.7 cm left breast mass.  A core biopsy was performed with immunohistochemistry.  Lumpectomy and sentinel lymph node biopsy were completed two months later.  MammaPrint$^{\textregistered}$ and BluePrint$^{\textregistered}$ gene expression profilers were performed on an excision block.  Microscopically, the tumor was composed of circumscribed nests of columnar cells, with focal papillary architecture.  Tumor cells had apically located nuclei with grooves and rare inclusions. Tumor cells were positive for CK5, IDH1/2, and calretinin, and myoepithelial cells were absent.  BluePrint$^{\textregistered}$ subtyped the tumor as basaloid.  MammaPrint$^{\textregistered}$ classified the tumor as high risk for metastasis.  TCCRP presents a diagnostic challenge.  Although these rare breast carcinomas are generally reported to have an indolent clinical course, molecular analysis by gene expression profiling classified this tumor as high risk of recurrence with a basaloid type.  Therefore, molecular analysis of this tumor may lead to conflicting data regarding prognosis and treatment considerations.  Clinicians and patients should weigh published data and individual prognostic information for treatment planning.  Our patient and clinical team opted for radiation without chemotherapy.  More cases of TCCRP need to be studied to better understand its molecular profile.

Tall cell carcinoma of the breast with reversed polarity (TCCRP) with mutations in the IDH2 and PIK3CA genes: a case report

2020 ◽  
Vol 47 (6) ◽  
pp. 4917-4921
Author(s):  
Simon Haefliger ◽  
Simone Muenst ◽  
Philip Went ◽  
Michel Bihl ◽  
Sophie Dellas ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Carcinoma Of The Breast ◽  
Tall Cell ◽  
Reversed Polarity

scholarly journals Tall cell carcinoma with reversed polarity – a case report

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S30-S31
Author(s):  
Anurita Kar ◽  
Fouzia Ziad
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Tall Cell ◽  
Reversed Polarity

scholarly journals Tall cell carcinoma with reversed polarity: case report with gene sequencing and literature review

Gland Surgery ◽  
2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yufan Wei ◽  
Liming Ding ◽  
Xin Song ◽  
Xia Tian ◽  
Ningning Min ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Gene Sequencing ◽  
Tall Cell ◽  
Reversed Polarity

Tall Cell Carcinoma of the Thyroid:

1997 ◽  
Vol 2 (5) ◽  
pp. 196-199 ◽  
Author(s):  
Maria J. Merino ◽  
Carlos Monteagudo
Keyword(s):  
Cell Carcinoma ◽  
Tall Cell

scholarly journals Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity

2020 ◽  
Vol 33 (6) ◽  
pp. 1056-1064 ◽  
Author(s):  
Fresia Pareja ◽  
Edaise M. da Silva ◽  
Denise Frosina ◽  
Felipe C. Geyer ◽  
John R. Lozada ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Immunohistochemical Analysis ◽  
Reverse Polarity ◽  
Tall Cell ◽  
Hotspot Mutations

scholarly journals Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review

Gland Surgery ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 837-843
Author(s):  
Xiaohui Zhang ◽  
Huanwen Wu ◽  
Zhe Wang ◽  
Yidong Zhou ◽  
Feng Mao ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Gene Sequencing ◽  
Reverse Polarity ◽  
Carcinoma Of The Breast ◽  
Tall Cell
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