scholarly journals 5-HT1A and 5-HT2A Signaling, Desensitization, and Downregulation: Serotonergic Dysfunction and Abnormal Receptor Density in Schizophrenia and the Prodrome

Cureus ◽  
2021 ◽  
Author(s):  
Sun A Kim
Keyword(s):  
Receptor Density ◽  
Serotonergic Dysfunction

Interferon-alpha treatment and serotonergic dysfunction

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
M Schaefer ◽  
M Schwaiger ◽  
M Pich ◽  
E Franke ◽  
R Uebelhack ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Serotonergic Dysfunction ◽  
Interferon Alpha Treatment

Increased Serotonin Transporter Availability in the Brainstem of Migraineurs – In vivo Evidence for a Serotonergic Dysfunction in Migraineurs

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
S Schuh-Hofer ◽  
M Richter ◽  
L Geworski ◽  
A Villringer ◽  
H Israel ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonergic Dysfunction

Increased Myocardial Muscarinic Receptor Density in Idiopathic Dilated Cardiomyopathy

Circulation ◽  
1997 ◽  
Vol 96 (10) ◽  
pp. 3416-3422 ◽  
Author(s):  
Dominique Le Guludec ◽  
Alain Cohen-Solal ◽  
Jacques Delforge ◽  
Nicolas Delahaye ◽  
André Syrota ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Muscarinic Receptor ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Receptor Density

scholarly journals Treatment-resistant schizophrenia characterised by dopamine supersensitivity psychosis and efficacy of asenapine

2021 ◽  
Vol 14 (4) ◽  
pp. e242495
Author(s):  
Nagara Takao ◽  
Toshiya Murai ◽  
Hironobu Fujiwara
Keyword(s):  
Animal Studies ◽  
Significant Proportion ◽  
Antipsychotic Treatment ◽  
High Dose ◽  
Receptor Density ◽  
Treatment Resistant ◽  
Psychomotor Activity ◽  
Receptor Blockers ◽  
Dopamine Supersensitivity

Dopamine supersensitivity psychosis (DSP) frequently arises with long-term antipsychotic treatment and accounts for a significant proportion of treatment-resistant schizophrenia. The mechanism underlying DSP is thought to be a compensatory increase in dopamine receptor density in the striatum caused by long-term antipsychotic treatment. Previous animal studies have reported that antipsychotics increase serotonin 5-HT2A receptor density in the striatum and that 5-HT2A receptor blockers suppress dopamine-sensitive psychomotor activity, which may be linked to the pathophysiology of DSP. In this paper, we describe a patient who was hospitalised with treatment-resistant schizophrenia. Following treatment with high-dose antipsychotic polypharmacy for 10 weeks, the patient experienced worsening of psychotic and extrapyramidal symptoms. The patient was then started on second-generation antipsychotic asenapine while other antipsychotics were tapered off, resulting in improvement of these symptoms. Retrospectively, we presumed that the high-dose antipsychotic polypharmacy caused DSP, which was effectively treated by the potent 5-HT2A receptor antagonism of asenapine.

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