scholarly journals Infective Endocarditis Involving Mitral and Aortic Valves With Interatrial Septal Abscess

Cureus ◽  
2021 ◽  
Author(s):  
Jean Kim ◽  
James Ha ◽  
Christina Park ◽  
Eric Y Chung
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valves ◽  
Septal Abscess

scholarly journals Anti-Ace monoclonal antibody reduces Enterococcus faecalis aortic valve infection in a rat infective endocarditis model

2018 ◽  
Vol 76 (8) ◽  
Author(s):  
Kavindra V Singh ◽  
Kenneth L Pinkston ◽  
Peng Gao ◽  
Barrett R Harvey ◽  
Barbara E Murray
Keyword(s):  
Monoclonal Antibody ◽  
Infective Endocarditis ◽  
Enterococcus Faecalis ◽  
Collagen Iv ◽  
Aortic Valves ◽  
Collagen Binding ◽  
Passive Protection ◽  
A Cell ◽  
Pre Treatment

AbstractAce (Adhesin to collagen from Enterococcus faecalis) is a cell-wall anchored protein that is expressed conditionally and is important for virulence in a rat infective endocarditis (IE) model. Previously, we showed that rats immunized with the collagen binding domain of Ace (domain A), or administered anti-Ace domain A polyclonal antibody, were less susceptible to E. faecalis endocarditis than sham-immunized controls. In this work, we demonstrated that a sub nanomolar monoclonal antibody (mAb), anti-Ace mAb70, significantly diminished E. faecalis binding to ECM collagen IV in in vitro adherence assays and that, in the endocarditis model, anti-Ace mAb70 pre-treatment significantly reduced E. faecalis infection of aortic valves. The effectiveness of anti-Ace mAb against IE in the rat model suggests it might serve as a beneficial agent for passive protection against E. faecalis infections.

Infective endocarditis and its complications

2021 ◽  
Vol 2 ◽  
pp. 62-67
Author(s):  
Elizaveta Kiseleva ◽  
◽  
Evgeny Kozlitin ◽  
Alexey Kalyagin ◽  
Natalya Balabina ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Infective Endocarditis ◽  
Drug Addiction ◽  
Clinical Picture ◽  
Clinical Observation ◽  
Intravenous Drug ◽  
Aortic Valves ◽  
Etiological Factors

The article presents a clinical observation of infective endocarditis of the tricuspid and aortic valves in a patient suffering from intravenous drug addiction. A feature of this observation is the developed multiple complications — ischemic stroke, pneumonia, spleen infarction. The diagnosis of infective endocarditis became possible after the appearance of the clinical picture of ischemic stroke. Clinical observation demonstrates the need to take into account all possible etiological factors in the event of a picture of ischemic stroke in the process of diagnosis.

scholarly journals Complete Atrioventricular Canal Defect with Infective Endocarditis in a Neonate

2020 ◽  
Vol 5 (02) ◽  
pp. 168-170
Author(s):  
V.S. Bharathi Lakshmi
Keyword(s):  
Infective Endocarditis ◽  
Atrioventricular Canal ◽  
Aortic Valves ◽  
New Born ◽  
Common Atrium ◽  
Atrioventricular Canal Defect ◽  
The Common ◽  
Born Baby ◽  
Complete Atrioventricular

AbstractThis is the case of a new born baby with complete atrioventricular (AV) canal defect with common atrium and vegetations on the common AV, pulmonary, and aortic valves.

Clinical characteristics and outcome of infective endocarditis in adults with bicuspid aortic valves: a multicentre observational study

Heart ◽  
2010 ◽  
Vol 96 (21) ◽  
pp. 1723-1729 ◽  
Author(s):  
C. Tribouilloy ◽  
D. Rusinaru ◽  
C. Sorel ◽  
F. Thuny ◽  
J.-P. Casalta ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Observational Study ◽  
Clinical Characteristics ◽  
Aortic Valves ◽  
Bicuspid Aortic Valves

scholarly journals Application of the Konno procedure for infective endocarditis in native bicuspid aortic valve with annular abscess extending into the interventricular septum

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Toshio Doi ◽  
Kanetsugu Nagao ◽  
Hayato Obi ◽  
Akihiko Higashida ◽  
Masaya Aoki ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valve ◽  
Interventricular Septum ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Left Ventricular Outflow ◽  
Surgical Field ◽  
Annular Abscess ◽  
Complex Surgery ◽  
Septal Abscess

Abstract Annular abscess is a serious complication of infective endocarditis, which often requires complex surgery and has a very high post-operative mortality rate. The Konno procedure involves valve annuloplasty for a narrow aortic annulus or left ventricular outflow tract stenosis in children; it is also performed for various cardiac conditions in adults. Here, we report a case of the Konno procedure performed in a patient with aortic valve infective endocarditis, with an annular abscess extending into the interventricular septum (IVS). A 58-year-old man who presented to our hospital with fever was diagnosed with aortic valve infective endocarditis caused by Streptococcus saccharolyticus. On echocardiography, an annular abscess in the direction of the IVS was detected, and surgery was planned. The Konno procedure was performed to secure an adequate surgical field and to debride and reconstruct the cavity created by the interventricular septal abscess. The patient was discharged uneventfully 29 days after surgery.

Bacterial Biofilms in Infective Endocarditis – A complex in vitro - Model to Investigate Emerging Technologies of Antimicrobial Cardiovascular Device Coatings

2020 ◽  
Author(s):  
Laura Kursawe ◽  
Alexander Lauten ◽  
Marc Martinović ◽  
Klaus Affeld ◽  
Ulrich Kertzscher ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Heart Valves ◽  
In Vitro Model ◽  
Bacterial Biofilm ◽  
Bacterial Biofilms ◽  
Aortic Valves ◽  
Biofilm Growth ◽  
Vitro Model ◽  
Biofilm Development

<p><strong>Objective:</strong> Most biofilm flow-chambers are designed for standardized homogeneous biofilms for research purposes. These do not mimic the complexity of prosthetic heart valves, which consist of both artificial and biological material.</p> <p>Infective endocarditis (IE) is still associated with a high morbidity and mortality. IE is characterized by bacterial biofilms of the endocardium leading to destruction of the valve. Current research demonstrates that about one quarter of the patients with formal surgery indication cannot undergo surgery. This group of patients needs further options of therapy, but due to a lack of models for IE, prospects of research are low.</p> <p>Therefore, the purpose of this project was to establish an in vitro - model of infective endocarditis to allow growth of bacterial biofilms on porcine aortic valves, serving as baseline for further research.</p> <p><strong>Methods and Results: </strong>A pulsatile two-chamber circulation model was constructed that kept native porcine aortic valves under sterile, physiologic hemodynamic and temperature conditions. To exclude external contamination, sterility tests with sterile culture media were performed for 24h. During this time period, no growth of microorganisms was observed in the system and cultures after plating on standard media remained negative.</p> <p>The system was inoculated with Staphylococcus epidermidis PIA 8400 to create biofilms on porcine aortic valves. Porcine aortic roots were incubated in this system for increasing periods of time and bacterial titration to evaluate bacterial growth and biofilm development on the valves. After incubation, specimens were embedded and tissue sections were analyzed by Fluorescence in situ hybridization (FISH) for direct visualization of the biofilms and bacterial activity.</p> <p>Pilot tests for biofilm growth showed monospecies colonization consisting of cocci with time- and inocula-dependent increase. FISH visualized biofilms with ribosome-containing, and thus metabolic active cocci, tissue infiltration and similar colonization pattern as observed by FISH in human IE heart valves infected by S. epidermidis.</p> <p><strong>Conclusion:</strong> These results demonstrate the establishment of a novel complex in vitro - model for bacterial biofilm growth on porcine aortic roots. The model will allow identifying predilection sites of heart valves for bacterial adhesion and biofilm growth and it may serve as baseline for further research on IE therapy and prevention, e.g. the development of antimicrobial transcatheter approaches to IE.</p>

Infective endocarditis on stenotic aortic valves

1988 ◽  
Vol 9 (suppl E) ◽  
pp. 43-49 ◽  
Author(s):  
J. P. Delahaye ◽  
R. Loire ◽  
H. Milon ◽  
G. D. De Gevigney ◽  
F. Delahaye ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valves

Pulmonary valve reconstruction using Ozaki’s technique for infective endocarditis

2020 ◽  
Author(s):  
Cristian Yepez ◽  
Josias Ríos
Keyword(s):  
Infective Endocarditis ◽  
Surgical Management ◽  
Pulmonary Valve ◽  
Pulmonary Regurgitation ◽  
Aortic Valves ◽  
Autologous Pericardium ◽  
Valve Reconstruction

Abstract Simultaneous pulmonary and aortic endocarditis is extremely rare, and there is no consensus on its surgical management. Here, we report a case of infective endocarditis of pulmonary and aortic valves complicated by severe pulmonary regurgitation due to complete damage of valve cusps. We performed pulmonary valve reconstruction using autologous pericardium using Ozaki’s technique, with excellent outcomes.

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