scholarly journals The Effectiveness of Electroconvulsive Therapy on Catatonia in a Case of Anti-N-Methyl-D-Aspartate (anti-NMDA) Receptor Encephalitis

Cureus ◽  
2021 ◽  
Author(s):  
Kehinde T Olaleye ◽  
Adeolu O Oladunjoye ◽  
David Otuada ◽  
Gibson O Anugwom ◽  
Tajudeen O Basiru ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Nmda Receptor Encephalitis

scholarly journals Complete cognitive recovery in a severe case of anti-N-methyl-d-aspartate receptor encephalitis treated with electroconvulsive therapy

2020 ◽  
Vol 13 (2) ◽  
pp. e233772
Author(s):  
Cæcilie Leding ◽  
Lisbet Marstrand ◽  
Anders Jorgensen
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Neuropsychiatric Symptoms ◽  
Behavioural Change ◽  
Severe Case ◽  
Cognitive Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cognitive Domains ◽  
Nmda Receptor Encephalitis

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis usually presents with prominent neuropsychiatric symptoms and many patients experience cognitive sequelae. Electroconvulsive therapy (ECT) has been suggested as a part of the treatment, particularly for catatonia, but concerns that ECT may worsen the cognitive function and long-term outcome may limit its use. We present a case of anti-NMDA receptor encephalitis with severe neuropsychiatric manifestations including refractory catatonia and behavioural change. A pre-ECT neuropsychological assessment revealed dysfunction in multiple cognitive domains in spite of intensive pharmacological treatment. Twenty days after the ninth and last ECT treatment, the patient underwent the same neuropsychological tests, which showed normalised test results within all cognitive domains and no need of rehabilitation. The case demonstrates that the use of ECT in anti-NMDA receptor encephalitis with severe pretreatment cognitive dysfunction can be associated with a highly favourable cognitive outcome.

scholarly journals Electroconvulsive therapy can improve psychotic symptoms in anti-NMDA-receptor encephalitis

2012 ◽  
Vol 66 (3) ◽  
pp. 242-243 ◽  
Author(s):  
Takuya Matsumoto ◽  
Kenji Matsumoto ◽  
Toshiyuki Kobayashi ◽  
Satoshi Kato
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Psychotic Symptoms ◽  
Nmda Receptor Encephalitis

scholarly journals Pearls & Oy-sters: Electroconvulsive therapy in anti-NMDA receptor encephalitis

Neurology ◽  
2010 ◽  
Vol 75 (10) ◽  
pp. e44-e46 ◽  
Author(s):  
H. M. H. Braakman ◽  
V. M. P. Moers-Hornikx ◽  
B. M. G. Arts ◽  
R. M. M. Hupperts ◽  
J. Nicolai
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Nmda Receptor Encephalitis

scholarly journals Pediatric anti-NMDA receptor encephalitis with catatonia: treatment with electroconvulsive therapy

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Taha Moussa ◽  
Khalid Afzal ◽  
Joseph Cooper ◽  
Ryan Rosenberger ◽  
Karyn Gerstle ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Nmda Receptor Encephalitis

scholarly journals P.002 Successful Treatment of Supra-Refractory Status Epilepticus Secondary to Anti-N-Methyl-D- Aspartate Receptor Encephalitis With Electroconvulsive Therapy

2021 ◽  
Vol 48 (s3) ◽  
pp. S20-S20
Author(s):  
A AlSabah ◽  
A Alshukaili ◽  
JS Teitelbaum
Keyword(s):  
Status Epilepticus ◽  
Nmda Receptor ◽  
Electroconvulsive Therapy ◽  
Refractory Status Epilepticus ◽  
Bilateral Oophorectomy ◽  
Nmda Receptor Encephalitis ◽  
Refractory Status ◽  
Healthy Female ◽  
Nr2 Subunits ◽  
New Onset

Background: Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is an autoimmune disease associated with antibodies against heteromers NR1 and NR2 subunits of the cell surface of the NMDA receptors, causing many psychiatric and neurological symptoms. This includes new-onset refractory status epilepticus. Methods: A 33-year-old previously healthy female developed new-onset refractory status epilepticus caused by anti- NMDA receptor encephalitis without the presence of tumours. Results: The clinical course was complicated by prolonged status epilepticus, which was refractory to many antiepileptic drugs (levetiracetam, phenytoin, carbamazepine, topiramate, lacosamide, valproic acid), ketamine, propofol, midazolam, including inhalation agents (isoflurane). Also, she received first (intravenous immunoglobulin, intravenous methylprednisolone, and plasmapheresis), second-line immunotherapy (rituximab) and prophylaxis bilateral oophorectomy without clinical or electrographic improvement. However, the patient drug-resistant status epilepticus markedly improved both clinically and electrographically following seven sessions of electroconvulsive therapy. Conclusions: Electroconvulsive therapy should be considered as adjuvant therapy for the treatment of immunotherapy resistant encephalitis.

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