scholarly journals A Case Series of Multiple Primary Malignancies Among Patients With Advanced Melanoma

Cureus ◽  
2021 ◽  
Author(s):  
Matthew I Ebia ◽  
Stephen Capone ◽  
Charité Ricker ◽  
Jacob S Thomas ◽  
Varsha Tulpule ◽  
...  
Keyword(s):  
Case Series ◽  
Advanced Melanoma ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

Multiple primary malignancies among patients with advanced melanoma.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e22531-e22531
Author(s):  
Matthew Isaiah Ebia ◽  
Gino Kim In
Keyword(s):  
Median Time ◽  
Immune Suppression ◽  
Advanced Melanoma ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Synchronous Tumor ◽  
Primary Tumors ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

e22531 Background: Multiple primary malignancies (MPMs) describe two or more primary tumors arising in a synchronous or metachronous manner in the same individual. Patients with a primary cutaneous melanoma are at high risk of developing MPMs. While melanoma and other tumors are highly immunogenic and may cause immune suppression at the individual level, the molecular underpinnings of immune suppression among patients with MPMs remains to be elucidated. Here, we attempt to describe this rare, but unique group of patients who have both advanced melanoma and at least one other primary malignancy. Methods: Patients with advanced melanoma (stage III-IV disease) and at least one other non-melanoma cancer were identified. Synchronous tumors were defined as those occurring within 6 months of the first primary cancer. Metachronous tumors were defined as those occurring at least 6 months after the first primary cancer. Patients who had melanoma first, before a second cancer, and those who had a prior other cancer first, followed by melanoma were included. Overall survival (OS) describes the time from diagnosis of the first primary cancer to death due to any cause. Two-sample t-tests were used to compare OS among these groups with statistical significance if p < 0.05. Results: Eleven patients with MPMs including advanced melanoma were identified. Advanced melanoma was the first primary tumor in 5 patients and the second primary in 6 patients. A synchronous second primary was observed in 4 patients, whereas a metachronous second primary was observed in 7 patients. The median time between the diagnosis of the first primary cancer to the second primary was 21 months and the median time between the diagnosis of a second primary to a third primary was also 21 months. The median OS for all patients was 73 months. The median OS for synchronous MPMs and metachronous MPMs were 64.5 months and 82 months, respectively (p = 0.013). For patients with melanoma as the first primary cancer, the median OS was 73 months, compared to 87 months when melanoma was the second primary cancer (p = 0.785). Among all 11 patients, two are deceased, while the remaining patients are under surveillance. Among the remaining 9 patients, 100% have no evidence of disease with respect to melanoma. Conclusions: Despite the favorable outcomes from early detection and the advanced treatments available such as immunotherapy, a robust treatment plan should be in place when advanced melanoma is diagnosed as a synchronous tumor or second primary cancer. Further research is warranted since there are no guidelines available for the treatment of MPMs.

Multiple Primary Malignancies in Patients with Head and Neck Cancer

2007 ◽  
Vol 58 (2) ◽  
pp. 205-205
Author(s):  
H. Iguchi ◽  
M. Kusuki ◽  
A. Nakamura ◽  
A. Kanazawa ◽  
K. Hachiya ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

scholarly journals Multiple primary malignancies involving lung cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Feng Li ◽  
Wen-Zhao Zhong ◽  
Fei-Yu Niu ◽  
Ning Zhao ◽  
Jin-Ji Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors

2008 ◽  
Vol 97 (7) ◽  
pp. 592-595 ◽  
Author(s):  
Volker Fendrich ◽  
Jens Waldmann ◽  
Detlef K. Bartsch ◽  
Katja Schlosser ◽  
Matthias Rothmund ◽  
...  
Keyword(s):  
Endocrine Tumors ◽  
Multiple Primary Malignancies ◽  
Pancreatic Endocrine Tumors ◽  
Multiple Primary

Multiple Primary Malignancies of Cancer of Ovary and Cervix in A Young Woman: A Rare Case Report

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Sangeeta Pankaj ◽  
Anjili Kumari ◽  
Syed Nazneen ◽  
Jaya Kumari ◽  
Vijayanand Choudhary ◽  
...  
Keyword(s):  
Case Report ◽  
Young Woman ◽  
Rare Case ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Rare Case Report

scholarly journals Multiple primary cancers: An enigma

2016 ◽  
Vol 05 (01) ◽  
pp. 29-32 ◽  
Author(s):  
Amitabh Jena ◽  
Rashmi Patnayak ◽  
Amancharla Yadagiri Lakshmi ◽  
Banoth Manilal ◽  
Mandyam Kumaraswamy Reddy
Keyword(s):  
Cancer Patients ◽  
Surgical Oncology ◽  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Primary Malignancy ◽  
Term Survival ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Synchronous Malignancies ◽  
Age Range

Abstract Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

scholarly journals High-Tech radiotherapy for primary prostate cancers and synchronous other tumor in elderly

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Alessia Surgo ◽  
◽  
Ilaria Bonaparte ◽  
Fabiana Gregucci ◽  
Roberta Carbonara ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Seminal Vesicles ◽  
High Tech ◽  
Multiple Primary Malignancies ◽  
Primary Prostate Cancer ◽  
Multiple Primary ◽  
Synchronous Cancers ◽  
Prostate Cancers ◽  
Radio Chemotherapy

Aims: To report feasibility and efficacy of high-tech Radiotherapy (RT) for the treatment of synchronous Multiple Primary Malignancies (sMPM) for elderly patients with primary Prostate Cancer (PC). Methods: Two elderly patients with PC and synchronous Anal Cancer (AC) and sacrum chordoma, respectively, were described. The first one was treated with radical radio-chemotherapy. A total dose of 70 Gy / 65.5 Gy (28 fractions) was prescribed to prostate/ seminal vesicles, and concomitantly, 56 Gy / 50.4 Gy / 45 Gy were prescribed to tumor, anal canal/mesorectum/pelvic nodes, and inguinal nodes, respectively. For the second case, after resection of chordoma, adjuvant and prostate radical RT (65.5 Gy / 70 Gy) in 28 fractions were used. In both cases, Volumetric-Arc RT was performed. Results: Patients completed the planned treatment without severe toxicities. After a median follow-up of 12 months, no sign of PC and a controlled/reduction of chordoma/AC were observed. Conclusion: High-tech RT is safe and effective for sMPM elderly patients. Keywords: Synchronous cancers; Elderly; Treatment; Radiotherapy; Multidisciplinary evaluation.

Multiple primary malignancies in patients with prostate cancer: increased risk of secondary malignancies after radiotherapy

2012 ◽  
Vol 18 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
Kaoru Okajima ◽  
Kazuki Ishikawa ◽  
Tomohiro Matsuura ◽  
Hitoshi Tatebe ◽  
Kazuhisa Fujiwara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Secondary Malignancies ◽  
Multiple Primary Malignancies ◽  
Increased Risk ◽  
Multiple Primary

Laboratory for Patients at Risk of Multiple Primary Malignancies

2009 ◽  
pp. 211-220
Author(s):  
Marcello Caggiano ◽  
Angela Mariano ◽  
Massimiliano Zuccaro ◽  
Sergio Spiezia ◽  
Marco Clemente ◽  
...  
Keyword(s):  
At Risk ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Patients At Risk
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