scholarly journals Diarrhea and Acute Tubular Necrosis Mimicking Hemolytic Uremic Syndrome in a Man With Immunoglobulin A (IgA) Nephropathy

Cureus ◽  
2021 ◽  
Author(s):  
Jayaram Saibaba ◽  
Jayachandran Selvaraj ◽  
Stalin Viswanathan ◽  
Vivekanandan Pillai ◽  
Bheemanathi H Srinivas ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Iga Nephropathy ◽  
Acute Tubular Necrosis ◽  
Immunoglobulin A ◽  
Tubular Necrosis ◽  
Uremic Syndrome

scholarly journals Renal hemosiderosis presenting with acute kidney Injury and macroscopic hematuria in Immunoglobulin A nephropathy: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Shinya Taguchi ◽  
Sumi Hidaka ◽  
Mitsuru Yanai ◽  
Kunihiro Ishioka ◽  
Kenji Matsui ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Biopsy ◽  
Prussian Blue ◽  
Iga Nephropathy ◽  
Acute Tubular Necrosis ◽  
Immunoglobulin A ◽  
Kidney Injury ◽  
Upper Respiratory Tract ◽  
Macroscopic Hematuria ◽  
Tubular Necrosis

Abstract Background Macroscopic hematuria-associated acute kidney injury (AKI) is a well-known complication of immunoglobulin A (IgA) nephropathy. In such cases, intratubular obstruction by red blood cell (RBC) casts and acute tubular necrosis are mainly observed pathologically. Herein, we report the case of a patient with IgA nephropathy presenting with AKI following an episode of macrohematuria. The patient presented with severe renal tubular hemosiderosis and acute tubular necrosis and without any obvious obstructive RBC casts. Case presentation A 68-year-old woman, who was diagnosed with IgA nephropathy on renal biopsy 6 years ago, was admitted to our hospital after an episode of macroscopic glomerular hematuria and AKI following upper respiratory tract infection. Renal biopsy showed mesangial proliferation of the glomeruli, including crescent formation in 17 % of the glomeruli, and acute tubular necrosis without obvious hemorrhage or obstructive RBC casts. The application of Perls’ Prussian blue stain showed hemosiderin deposition in the renal proximal tubular cells. Immunofluorescence showed granular mesangial deposits of IgA and C3. Based on these findings, she was diagnosed with acute tubular necrosis with a concurrent IgA nephropathy flare-up. Moreover, direct tubular injury by heme and iron was considered to be the cause of AKI. She was treated with intravenous pulse methylprednisolone followed by oral prednisolone. Thereafter, the gross hematuria gradually faded, and her serum creatinine levels decreased. Conclusions IgA nephropathy presenting with acute kidney injury accompanied by macrohematuria may cause renal hemosiderosis and acute tubular necrosis without obstructive RBC casts. Hemosiderosis may be a useful indicator for determining the pathophysiology of macroscopic hematuria-associated AKI. However, renal hemosiderosis may remain undiagnosed. Thus, Perls’ Prussian blue iron staining should be more widely used in patients presenting with hematuria.

Atypical Hemolytic Uremic Syndrome Associated with Complement Factor H Mutation and IgA Nephropathy: A Case Report Successfully Treated with Eculizumab

Nephron ◽  
2017 ◽  
Vol 138 (4) ◽  
pp. 324-327 ◽  
Author(s):  
Hironori Nakamura ◽  
Mariko Anayama ◽  
Mutsuki Makino ◽  
Yasushi Makino ◽  
Katsuhiko Tamura ◽  
...  
Keyword(s):  
Case Report ◽  
Hemolytic Uremic Syndrome ◽  
Iga Nephropathy ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Uremic Syndrome ◽  
Factor H Mutation

scholarly journals Association of acute tubular necrosis with gross hematuria in cirrhosis-related immunoglobulin A nephropathy

2013 ◽  
Vol 32 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Jang Soo Han ◽  
So Dug Lim ◽  
Won Hyeok Choi ◽  
Sung Chul Hong ◽  
Jung Hee Park ◽  
...  
Keyword(s):  
Acute Tubular Necrosis ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Gross Hematuria ◽  
Tubular Necrosis

IgA nephropathy and atypical hemolytic uremic syndrome: a case series and a literature review

2021 ◽  
Author(s):  
Lucio Manenti ◽  
Giovanni Maria Rossi ◽  
Isabella Pisani ◽  
Micaela Gentile ◽  
Francesco Fontana ◽  
...  
Keyword(s):  
Literature Review ◽  
Hemolytic Uremic Syndrome ◽  
Iga Nephropathy ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Case Series ◽  
Uremic Syndrome

IgA Nephropathy: Acute Renal Failure, Acute Tubular Necrosis, and Features of Postinfectious Acute Glomerulonephritis

Renal Failure ◽  
1992 ◽  
Vol 14 (4) ◽  
pp. 533-539 ◽  
Author(s):  
Helga Maria Mazzarolo-Cruz ◽  
Décio de Oliveira Penna ◽  
Luis Balthazar Saldanha ◽  
Elza Hissako Kanashiro ◽  
Jenner Cruz ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Iga Nephropathy ◽  
Acute Tubular Necrosis ◽  
Acute Glomerulonephritis ◽  
Tubular Necrosis

Hemolytic–uremic syndrome, malignant hypertension and IgA nephropathy: Successful treatment with plasma exchange therapy

2012 ◽  
Vol 47 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Chrysoula Pipili ◽  
Konstantinos Pantelias ◽  
Nikos Papaioannou ◽  
Helen Paraskevakou ◽  
Eirini Grapsa
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Plasma Exchange ◽  
Iga Nephropathy ◽  
Successful Treatment ◽  
Malignant Hypertension ◽  
Plasma Exchange Therapy ◽  
Uremic Syndrome
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