scholarly journals Emergent Radiotherapy for Leukemia-Induced Cranial Neuropathies Refractory to Intrathecal Therapy

Cureus ◽  
2021 ◽  
Author(s):  
Nirav Patel ◽  
Benjamin J RIch ◽  
Shareen Patel ◽  
Justin M Watts ◽  
Ronald Benveniste ◽  
...  
Keyword(s):  
Intrathecal Therapy ◽  
Cranial Neuropathies

Ziconotide Intrathecal Therapy

Pain ◽  
2019 ◽  
pp. 311-314
Author(s):  
Samita S. Das ◽  
Salim M. Hayek
Keyword(s):  
Intrathecal Therapy

scholarly journals Clival metastasis from a gastrointestinal adenocarcinoma causing multiple cranial neuropathies

2017 ◽  
pp. bcr-2017-222725
Author(s):  
Charlotte Lee ◽  
Jesse M Thon ◽  
Amar Dhand
Keyword(s):  
Cranial Neuropathies

scholarly journals Confounding case of seromucinous hamartoma

2021 ◽  
Vol 14 (3) ◽  
pp. e240460
Author(s):  
Neal Rajan Godse ◽  
Giuseppe Vittorio Staltari ◽  
Katherine Doeden ◽  
Grant Shale Gillman
Keyword(s):  
Myasthenia Gravis ◽  
Vocal Fold ◽  
Cranial Nerves ◽  
Vocal Fold Paralysis ◽  
Seromucinous Hamartoma ◽  
Cranial Neuropathies ◽  
Receptor Antibodies ◽  
Bony Erosion ◽  
Ct And Mri ◽  
Anti Acetylcholine

A 67-year-old man presented with progressive diplopia. On evaluation, he was noted to have bilateral palsies of cranial nerves III, IV and VI as well as a unilateral right true vocal fold paralysis. CT and MRI studies demonstrated a T2-bright left ethmoid mass with no evidence of bony erosion. Direct visualisation demonstrated a polypoid appearing mass of the left sphenoethmoid recess. Operative biopsy was pursued with final pathology demonstrating benign seromucinous hamartoma. Subsequent blood work demonstrated high titres of anti-acetylcholine receptor antibodies consistent with myasthenia gravis. The patient was started on pyridostigmine with improvement in his ocular cranial neuropathies.

scholarly journals DIPG-72. LONG-TERM SURVIVAL OF A CLASSIC DIFFUSE INTRINSIC PONTINE GLIOMA TREATED WITH NIMOTUZUMAB

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii301-iii301
Author(s):  
Sidnei Epelman ◽  
Vijay Ramaswamy ◽  
Ethel Gorender ◽  
Luis Henrique Sakamoto
Keyword(s):  
Diffuse Intrinsic Pontine Glioma ◽  
Pontine Glioma ◽  
Tumor Biopsy ◽  
Term Survival ◽  
Long Term Survival ◽  
Good School ◽  
Cranial Mri ◽  
Cranial Neuropathies ◽  
Image Assessment

Abstract BACKGROUND Long-term survival in diffuse intrinsic pontine glioma is rare, and typically associated with atypical imaging and/or atypical clinical course. Although most patients harbor hotspot mutations in H3.1/3-K27M, a proportion of patients have alternate mutations, despite a typical clinicoradiological course. Herein we describe a long-term survivor with a classical presentation, treated with nimotuzumab, highlighting the challenges associated with such cases. CASE REPORT: A 5 year old male, diagnose in 2012 with a 10 day history multiple cranial neuropathies and a right hemiparesis. Cranial MRI revealed a poorly delimited diffuse pontine tumor and secondary hydrocephalus. Tumor biopsy was not performed due to the classic clinical presentation, and he received 54Gy/30 of radiation plus concomitant weekly nimotuzumab 150mg/m2. Initial tumor dimensions were 43x31x28mm. Nimotuzumab 150mg/m2 was continued every 2 weeks. Image assessment at week 12 of treatment revealed 16.9% volume increase, 4 weeks after radiotherapy completion. Nevertheless, subsequent neuroimaging at 24th, 36th, 60th, 96th and 108th weeks of nimotuzumab therapy showed a sustained and progressive tumor cytoreduction of 47.5%, 59%, 62.2%, 63.8% and 67%, respectively, when compared with post-radiotherapy dimensions. Currently, the patient is 13y old, good school performance, no neurologic disabilities. The last MRI at 394 weeks of nimotuzumab revealed dimensions of 21x19x14mm which corresponds to 70% of reduction compared with initial volume. CONCLUSIONS Our case of progressive cytoreduction over two years of a classic DIPG, diagnosed in the era prior to the discovery of the K27M mutation, highlights the challenges associated with long-term survival of this devastating entity.

Intrathecal Therapy

1972 ◽  
pp. 47-81
Author(s):  
Lawrence E. Broder ◽  
Stephen K. Carter
Keyword(s):  
Intrathecal Therapy

scholarly journals Intrathecal Therapy for Chronic Pain: A Review of Morphine and Ziconotide as Firstline Options

Pain Medicine ◽  
2018 ◽  
Vol 20 (4) ◽  
pp. 784-798 ◽  
Author(s):  
Timothy R Deer ◽  
Jason E Pope ◽  
Michael C Hanes ◽  
Gladstone C McDowell
Keyword(s):  
Chronic Pain ◽  
Intrathecal Therapy

Cranial Neuropathies II, III, IV, and VI

2020 ◽  
pp. 693-716
Author(s):  
Tanyatuth Padungkiatsagul ◽  
Heather E. Moss
Keyword(s):  
Cranial Neuropathies
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