scholarly journals Metaplastic Breast Carcinoma: Clinicopathological Parameters and Prognostic Profile

Cureus ◽  
2021 ◽  
Author(s):  
Saroona Haroon ◽  
Shamail Zia ◽  
Umme Aiman Shirazi ◽  
Omer Ahmed ◽  
Ishaq Azeem Asghar ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Clinicopathological Parameters ◽  
Prognostic Profile ◽  
Metaplastic Breast Carcinoma

Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast

2019 ◽  
Vol 15 (3) ◽  
pp. 338-348
Author(s):  
Hale Aydin ◽  
Bahar Guner ◽  
Isil Esen Bostanci ◽  
Nazan Ciledag ◽  
Melda Boyacioglu Bulut ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Multimodality Imaging ◽  
Metaplastic Carcinoma ◽  
Imaging Features ◽  
Mri Findings ◽  
Radiologic Findings ◽  
Round Shape ◽  
Malignant Feature ◽  
Imaging Results ◽  
Metaplastic Breast Carcinoma

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

scholarly journals Diagnostic utility of snail in metaplastic breast carcinoma

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Aziza Nassar ◽  
Nicole Sookhan ◽  
Marta Santisteban ◽  
Sandra C Bryant ◽  
Judy C Boughey ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Diagnostic Utility ◽  
Metaplastic Breast Carcinoma

Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

scholarly journals Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tibor Tot ◽  
Juan José Badani De La Parra ◽  
Leif Bergkvist
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Brain Metastases ◽  
Lymph Node Metastases ◽  
Metaplastic Carcinoma ◽  
Unique Case ◽  
Carcinoma Of The Breast ◽  
Stromal Component ◽  
Node Metastases ◽  
Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

CA 15–3 Serum Levels in Patients with Ductal Breast Carcinoma: Relationship with Clinicopathological Parameters and Tumor Markers

2012 ◽  
Vol 27 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Angel González-Sistal ◽  
José Ignacio Arias ◽  
Álvaro Ruibal
Keyword(s):  
Breast Carcinoma ◽  
Tumor Markers ◽  
Cathepsin D ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Serum Levels ◽  
S Phase ◽  
Phase Fraction ◽  
Clinicopathological Parameters ◽  
Ductal Breast Carcinoma

Introduction Cancer antigen 15–3 (CA 15–3) is the most widely used serum marker in diagnosing and monitoring breast cancer. The aim of this work was to analyze preoperative CA 15–3 serum levels in patients with ductal breast carcinoma in relation to 1) clinicopathological parameters, 2) hormone receptors, and 3) tissue-based tumor markers. Methods A group of 340 women with infiltrating ductal carcinoma of the breast who had undergone no prior treatment was studied. These women ranged in age between 27 and 83 years (mean age 61.5±9.9 years). Preoperative CA 15–3 serum levels were determined by an immunoradiometric method. Hormone receptors (estrogen, progesterone and androgen receptors), p53, bcl-2 and Ki67 were determined by different immunohistochemical methods. Epidermal growth factor receptor (EGFR) was analyzed in the cell membranes by radioligand assay whereas cathepsin D and pS2 were determined by immunoradiometric analysis. Tumor ploidy and S-phase fraction were studied by flow cytometry. Results CA 15–3 serum levels were higher in postmenopausal women (p=0.032), in patients with tumors exceeding 2 cm (p=0.003), lymph node involvement (p=0.026), distant metastases (M1) (p<0.0001), S-phase fraction <7% (p=0.015), EGFR <6 fmol/mg protein (p=0.025), and cathepsin D <50 pmol/mg protein (p=0.023). Conclusions Preoperative CA 15–3 serum levels were associated with cell proliferation determined by the S-phase fraction, the concentration of cathepsin D in the cytosol, and the EGFR concentration in the cell membrane.

Metaplastic breast carcinoma: tumour histogenesis or dedifferentiation?

2011 ◽  
Vol 224 (4) ◽  
pp. 434-437 ◽  
Author(s):  
Carolien HM van Deurzen ◽  
Andrew HS Lee ◽  
Muhammad S Gill ◽  
Marian BE Menke-Pluijmers ◽  
Agnes Jager ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma

scholarly journals Immunohistochemical expression of cyclin D1 in invasive breast carcinoma and its correlation with clinicopathological parameters

2020 ◽  
Vol 63 (3) ◽  
pp. 376
Author(s):  
SiddhiGaurish Sinai Khandeparkar ◽  
PranotiVitthalrao Lengare ◽  
AvinashR Joshi ◽  
BageshriP Gogate ◽  
SmitaGaneshrao Solanke ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cyclin D1 ◽  
Invasive Breast Carcinoma ◽  
Clinicopathological Parameters ◽  
Immunohistochemical Expression

scholarly journals Current Progress in the Treatment of Metaplastic Breast Carcinoma

2013 ◽  
Vol 14 (11) ◽  
pp. 6221-6225 ◽  
Author(s):  
Qing Hu ◽  
Wei-Xian Chen ◽  
Shan-Liang Zhong ◽  
Jian Li ◽  
Zhou Luo ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Metaplastic Breast Carcinoma
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