scholarly journals Effect of Perioperative Tranexamic Acid on Allogeneic Blood Transfusions for Total Knee Arthroplasty Patients at a Community Hospital

Cureus ◽  
2021 ◽  
Author(s):  
Chukwuweike Gwam ◽  
Kylie Kroes ◽  
Kevin Wang ◽  
Arianne Wilson ◽  
Daniel P Bullock ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Community Hospital ◽  
Allogeneic Blood ◽  
Blood Transfusions ◽  
Total Knee

scholarly journals A randomized, non-crossover, parallel-group analysis of tranexamic acid in minimizing blood loss and transfusions in total knee arthroplasty

2021 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Nikhil Mudgalkar
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Acid Group ◽  
Total Blood Loss ◽  
Blood Transfusions ◽  
Total Blood ◽  
Parallel Group ◽  
Total Knee

Objectives: Total knee arthroplasty is associated with significant blood loss, necessitating blood transfusions. Due to the obvious risks and costs of allogeneic blood transfusions, techniques to minimize blood loss in surgery are needed. The objective of this study was to assess the efficacy of tranexamic acid treatment in reducing blood loss and blood transfusion requirements during total knee arthroplasty. Materials and Methods: A prospective, randomized, double-blind, parallel-group, non-crossover trial was carried out in Prathima Hospital, Karimnagar. The trial involved 28 ASA I and II patients undergoing unilateral knee arthroplasty, 14 in each of the control and study groups. In the study group, a 10 mg/kg bolus of tranexamic acid was administered slowly IV 30 min before tourniquet deflation, followed by a 1 mg/kg/hr infusion for 12 h, compared to the standard medical treatment in the control group. Total blood loss during and after surgery was compared between the two classes. We also compared the hemoglobin drop after surgery, the number of people who needed blood transfusions, and the number of units needed between the two classes. Any complications were also reported. Results: Total blood loss in the tranexamic acid group was 543.3 ± 184.85 versus 685.83 ± 176.74, a statistically significant difference (P < 0.05). Intraoperative blood loss was comparable, but post-operative blood loss was significantly lower in the tranexamic acid group (389.16 ± 174 ml vs. 514.36 ± 143.89 ml), indicating that it was statistically significant (P < 0.05). There were no complications reported from any of the groups. Conclusion: Tranexamic acid is an effective strategy for minimizing overall blood loss and blood transfusions in patients undergoing total knee arthroplasty.

scholarly journals Retrospective comparative study of IV+ local tranexamic acid versus IV tranexamic acid only in primary total knee replacement

2021 ◽  
Vol 7 (2) ◽  
pp. 308
Author(s):  
Sanil G. Kamat ◽  
Rohan Dessai
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Blood Transfusions ◽  
Operative Outcomes ◽  
Total Knee ◽  
Retrospective Comparative Study ◽  
Group 1

<p class="abstract"><strong>Background: </strong>The study is to compare the immediate post-operative outcomes with use of intravenous (IV) tranexamic acid (TXA) versus IV and local TXA combination in primary unilateral total knee arthroplasty. Study comprised of 72 cases of tricompartmental knee primary osteoarthritis who have undergone unilateral total knee arthroplasty at Manipal Hospital, Goa from January 2016 to December 2018. The observations for each group was analysed and post op blood loss in drain, fall of haemoglobin levels and need of blood transfusion was recorded. The results were statistically compared. The mean blood loss fall in HB levels and need of blood transfusions revealed statistically significant differences.</p><p class="abstract"><strong>Methods:</strong> Total 72 patients diagnosed with primary tricompartmental osteoarthritis were divided into two groups retrospectively. Group 1 (IV only): 1 gm IV Tranexamic acid bolus 10 min before deflating the tourniquet. Group 2 (IV + Local): 1 gm IV Tranexamic acid bolus 10 min before deflating the tourniquet and 1 gm Tranexamic Acid in 50 ml saline locally at the time of closure.</p><p class="abstract"><strong>Results: </strong>It was observed that higher post op blood loss, higher fall in haemoglobin (HB) levels and higher requirement of blood transfusions were associated with group 1 as compared to 2.</p><p class="abstract"><strong>Conclusions: </strong>The study inferred that the combination of local and systemic tranexamic acid was superior than systemic administration alone with lower post op blood loss, lower rates of blood transfusion and lower fall in haemoglobin levels without any added complications.</p>

scholarly journals Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty

2006 ◽  
Vol 50 (5) ◽  
pp. 593-599 ◽  
Author(s):  
P. A. M. Everts ◽  
R. J. J. Devilee ◽  
C. Brown Mahoney ◽  
M. Eeftinck-Schattenkerk ◽  
H. A. M. Box ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Fibrin Sealant ◽  
Allogeneic Blood ◽  
Blood Transfusions ◽  
Platelet Gel ◽  
Total Knee

Intra-articular Tranexamic Acid in Primary Total Knee Arthroplasty: Meta-analysis

2017 ◽  
Vol 31 (01) ◽  
pp. 056-067 ◽  
Author(s):  
Joseph Moskal ◽  
Susan Capps
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Transfusion ◽  
Blood Loss ◽  
Adverse Events ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Blood Transfusions ◽  
Total Knee

AbstractTotal knee arthroplasty (TKA) is associated with an increased need for blood transfusions and thus an increase in risks associated with blood transfusion such as transfusion reactions, infections, fluid overload, and altered mental status. Tranexamic acid (TXA) is an antifibrinolytic medication that can reduce perioperative blood loss in TKA. However, the best method of delivery has not been defined although topical intra-articular TXA (IA-TXA) may have a theoretical advantage as it is applied directly when and where it is needed to control bleeding. Blinded and nonblinded randomized controlled trials and case-controlled trials published since 2010 were found using database searches. Data were extracted and analyzed with the goal of discovering through meta-analysis if IA-TXA reduces blood loss, blood transfusions, and without increasing adverse events, especially thromboembolic events, compared with placebo. Blood loss from suction drains and calculated total blood loss were significantly lower in the IA-TXA group. The frequency of blood transfusion and the number of units of blood transfused were significantly lower in the IA-TXA group. The risk of adverse events was not increased for IA-TXA versus placebo. Topical IA-TXA in primary, unilateral TKA successfully reduces blood loss and the frequency of blood transfusions. In addition, it does not appear to increase the risk of thromboembolic adverse events. There is need for further research to determine the optimal dosage and the preferred delivery system of IA-TXA in TKA.

scholarly journals Total knee Arthroplasty: risk factors for allogeneic blood transfusions in the South Asian population

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Syed Hamza Mufarrih ◽  
Nada Qaisar Qureshi ◽  
Arif Ali ◽  
Azeem Tariq Malik ◽  
Huda Naim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Total Knee Arthroplasty ◽  
South Asian ◽  
Knee Arthroplasty ◽  
Asian Population ◽  
Allogeneic Blood ◽  
Blood Transfusions ◽  
The South ◽  
South Asian Population ◽  
Total Knee
Sign in / Sign up

Export Citation Format

Share Document