scholarly journals Hepatitis E Virus Superinfection: an Underrecognized Trigger of Acute Hepatitis B Virus Flare

Cureus ◽  
2021 ◽  
Author(s):  
Adham E Obeidat ◽  
Gabriel Monti ◽  
Wichit Sae-Ow ◽  
Hiroko Shinoda ◽  
Herbert Lim
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
B Virus ◽  
Acute Hepatitis B

scholarly journals Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 64
Author(s):  
Gergana Zahmanova ◽  
Milena Mazalovska ◽  
Katerina Takova ◽  
Valentina Toneva ◽  
Ivan Minkov ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nicotiana Benthamiana ◽  
Hepatitis E Virus ◽  
Chimeric Protein ◽  
Hepatitis E ◽  
Core Antigen ◽  
Efficient Production ◽  
Virus Like Particles ◽  
B Virus

The core antigen of hepatitis B virus (HBcAg) is capable of self-assembly into virus-like particles (VLPs) when expressed in a number of heterologous systems. Such VLPs are potential carriers of foreign antigenic sequences for vaccine design. In this study, we evaluated the production of chimeric HBcAg VLPs presenting a foreign epitope on their surface, the 551–607 amino acids (aa) immunological epitope of the ORF2 capsid protein of hepatitis E virus. A chimeric construct was made by the insertion of 56 aa into the immunodominant loop of the HBcAg. The sequences encoding the chimera were inserted into the pEAQ-HT vector and infiltrated into Nicotiana benthamiana leaves. The plant-expressed chimeric HBcHEV ORF2 551–607 protein was recognized by an anti-HBcAg mAb and anti-HEV IgG positive swine serum. Electron microscopy showed that plant-produced chimeric protein spontaneously assembled into “knobbly” ~34 nm diameter VLPs. This study shows that HBcAg is a promising carrier platform for the neutralizing epitopes of hepatitis E virus (HEV) and the chimeric HBcAg/HEV VLPs could be a candidate for a bivalent vaccine.

scholarly journals Acute Acalculous Cholecystitis Induced by Acute Hepatitis B Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Riyadh Ali Mohammed ◽  
Wisam Ghadban ◽  
Osama Mohammed
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Rare Complication ◽  
Acalculous Cholecystitis ◽  
Acute Acalculous Cholecystitis ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Acute Hepatitis B

During the course of acute viral hepatitis, some functional and anatomical changes to the gallbladder can occur. Acute acalculous cholecystitis (ACC) is a rare complication of acute hepatitis B virus infection; only few cases are reported as ACC associated with acute hepatitis B virus infection. ACC cases are self-limiting, while other limited cases can progress to a gangrenous state, perforation, and even death. We present a 27-year-old female case diagnosed to have acute acalculous cholecystitis and associated with acute hepatitis B virus infection, and she recovered within one week of her presentation without complication or surgical intervention.

Can subacute thyroiditis be associated with acute hepatitis B virus infection?

2012 ◽  
Vol 124 (9-10) ◽  
pp. 348-349 ◽  
Author(s):  
Adnan Tas ◽  
Yavuz Beyazit ◽  
Sehmuz Olmez ◽  
Hacer Celik ◽  
Selma Aktas
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Subacute Thyroiditis ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Acute Hepatitis B

scholarly journals Acute Hepatitis B Co-infection in HIV-Infected Patients Despite Prior Hepatitis B Vaccination

2017 ◽  
Vol 11 (4) ◽  
Author(s):  
S. Rolland ◽  
L. Antonova ◽  
J. Powis ◽  
T. Murdoch ◽  
D. Wong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Elevated Risk ◽  
Vaccination Status ◽  
Hbv Infection ◽  
Hepatitis B Vaccination ◽  
Hiv Patients ◽  
B Virus ◽  
Acute Hepatitis B

Clinicians often assume that patients vaccinated for hepatitis B virus (HBV) have immunity. We report three cases of acute HBV infection in HBV-vaccinated HIV patients. These cases illustrate that patients at an elevated risk of HBV exposure presenting with acute hepatitis should be tested for HBV infection regardless of previous vaccination status.

scholarly journals Prevalence of Hepatitis B Virus Subgenotypes and Basal Core Promoter, Precore Variants in Patients with Acute Hepatitis B in Central Vietnam

Intervirology ◽  
2009 ◽  
Vol 52 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Tran Xuan Chuong ◽  
Yasushi Takeda ◽  
Masatoshi Ishigami ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Central Vietnam ◽  
B Virus ◽  
Acute Hepatitis B

Detection of hepatitis B virus DNA in sera from patients with acute hepatitis B by an 125I-labeled DNA probe

1989 ◽  
Vol 9 ◽  
pp. S89
Author(s):  
M. Tarsopoulos ◽  
M. Kuhns ◽  
M. Koutelou ◽  
A. McNamara ◽  
P. Nicolakakis
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Dna Probe ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Acute Hepatitis B
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