scholarly journals Neurological Complications of COVID-19: Guillain-Barre Syndrome Following Pfizer COVID-19 Vaccine

Cureus ◽  
2021 ◽  
Author(s):  
Sadia Waheed ◽  
Angel Bayas ◽  
Fawzi Hindi ◽  
Zufe Rizvi ◽  
Patricio S Espinosa
Keyword(s):  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Rare variant of Guillain-Barré syndrome after chikungunya viral fever

2019 ◽  
Vol 12 (4) ◽  
pp. e228845 ◽  
Author(s):  
Sajid Hameed ◽  
Sara Khan
Keyword(s):  
Emergency Department ◽  
Early Diagnosis ◽  
Symptom Onset ◽  
Complete Resolution ◽  
Neurological Complications ◽  
Acute Onset ◽  
Guillain Barre Syndrome ◽  
Ventilator Support ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Chikungunya (CHIK) viral fever is a self-limiting illness that presents with severe debilitating arthralgia, myalgia, fever and rash. Neurological complications are rare. We present a case of a 36-year-old woman who presented with acute onset progressive difficulty swallowing and left arm weakness. She was diagnosed with CHIK viral fever 4 weeks prior to admission. After investigations, she was diagnosed with a pharyngeal–cervical–brachial variant of Guillain-Barré syndrome. In hospital, she required ventilator support. Her condition improved after five sessions of intravenous immunoglobulin with almost complete resolution within 6 months of symptom onset. With frequent CHIK outbreaks, the neurological complications are increasingly seen in the emergency department. The knowledge of these associations will result in early diagnosis and treatment.

scholarly journals Acute neuromuscular weakness associated with dengue infection

2012 ◽  
Vol 03 (01) ◽  
pp. 36-39 ◽  
Author(s):  
Harmanjit Singh Hira ◽  
Amandeep Kaur ◽  
Anuj Shukla
Keyword(s):  
Dengue Virus ◽  
Dengue Infection ◽  
Neurological Complications ◽  
Electrolyte Imbalance ◽  
Guillain Barre Syndrome ◽  
Motor Weakness ◽  
Presenting Symptoms ◽  
Guillain Barré Syndrome ◽  
Serotype 1 ◽  
Guillain Barré

ABSTRACT Background: Dengue infections may present with neurological complications. Whether these are due to neuromuscular disease or electrolyte imbalance is unclear. Materials and Methods: Eighty-eight patients of dengue fever required hospitalization during epidemic in year 2010. Twelve of them presented with acute neuromuscular weakness. We enrolled them for study. Diagnosis of dengue infection based on clinical profile of patients, positive serum IgM ELISA, NS1 antigen, and sero-typing. Complete hemogram, kidney and liver functions, serum electrolytes, and creatine phosphokinase (CPK) were tested. In addition, two patients underwent nerve conduction velocity (NCV) test and electromyography. Results: Twelve patients were included in the present study. Their age was between 18 and 34 years. Fever, myalgia, and motor weakness of limbs were most common presenting symptoms. Motor weakness developed on 2 nd to 4 th day of illness in 11 of 12 patients. In one patient, it developed on 10 th day of illness. Ten of 12 showed hypokalemia. One was of Guillain-Barré syndrome and other suffered from myositis; they underwent NCV and electromyography. Serum CPK and SGOT raised in 8 out of 12 patients. CPK of patient of myositis was 5098 IU. All of 12 patients had thrombocytopenia. WBC was in normal range. Dengue virus was isolated in three patients, and it was of serotype 1. CSF was normal in all. Within 24 hours, those with hypokalemia recovered by potassium correction. Conclusions: It was concluded that the dengue virus infection led to acute neuromuscular weakness because of hypokalemia, myositis, and Guillain-Barré syndrome. It was suggested to look for presence of hypokalemia in such patients.

scholarly journals Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil

2016 ◽  
Vol 74 (3) ◽  
pp. 253-255 ◽  
Author(s):  
Lucas Masiêro Araujo ◽  
Maria Lucia Brito Ferreira ◽  
Osvaldo JM Nascimento
Keyword(s):  
Zika Virus ◽  
French Polynesia ◽  
Neurological Complications ◽  
Standard Test ◽  
Guillain Barre Syndrome ◽  
Zikv Infection ◽  
Resource Limited ◽  
Guillain Barré Syndrome ◽  
Large Outbreak ◽  
Guillain Barré

ABSTRACT Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barré syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil. The diagnosis of GBS is feasible even in resource-limited areas using the criteria proposed by the GBS Classification Group, which is based solely on clinical grounds. Further understanding on the relationship of ZIKV with neurological complications is a research urgency.

scholarly journals Bilateral upper limb neuropathies following prone ventilation for COVID-19 pneumonia

2020 ◽  
pp. 10.1212/CPJ.0000000000000944
Author(s):  
William K Diprose ◽  
Laura Bainbridge ◽  
Richard W Frith ◽  
Neil E Anderson
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Link Type ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The neurological complications of COVID-19 and its treatment are still being elucidated.1,2 Guillain-Barré Syndrome has been reported in COVID-19 patients, but other peripheral nerve complications have not been described. We report a case of bilateral upper limb neuropathies in a patient with COVID-19 pneumonia managed with prolonged prone ventilation.

scholarly journals A 50-Year-Old Patient with Guillain–Barré Syndrome after COVID-19: A Case Report

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 775
Author(s):  
Tomasz Chmiela ◽  
Michalina Rzepka ◽  
Ewa Krzystanek ◽  
Agnieszka Gorzkowska
Keyword(s):  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Sensorimotor Polyneuropathy ◽  
Csf Analysis ◽  
First Case ◽  
Guillain Barré Syndrome ◽  
Sensory Disturbances ◽  
History Of ◽  
Diagnostic Work ◽  
Guillain Barré

Severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, causes acute respiratory disease (coronavirus disease 2019; COVID-19). However, the involvement of other mechanisms is also possible, and neurological complications are being diagnosed more frequently. Here, we would like to present a case of a Polish patient with Guillain–Barré syndrome (GBS), after a documented history of COVID-19: A 50-year-old man, 18 days after the onset of COVID-19 symptoms, had progressive quadriparesis preceded by 1-day sensory disturbances. Based on the clinical picture, the results of diagnostic work-up including a nerve conduction study (ENG) that revealed a demyelinating and axonal sensorimotor polyneuropathy, and cerebrospinal fluid (CSF) analysis that showed albumin–cytological dissociation, an acute inflammatory demyelinating polyneuropathy was confirmed, consistent with GBS. Upon a therapeutic plasma exchange (TPE), the patient’s condition improved. The presented case of GBS in a patient after mild COVID-19 is the first case in Poland that has supplemented those already described in the global literature. Attention should be drawn to the possibility of GBS occurring after SARS-CoV-2 infection, even when it has a mild course.

scholarly journals SARS-CoV-2 Infection and Guillain-Barré Syndrome

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 936
Author(s):  
Huda Makhluf ◽  
Henry Madany
Keyword(s):  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Neurological Deficits ◽  
Severe Illness ◽  
Special Focus ◽  
Neurological Manifestations ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Global Threat ◽  
Taste And Smell

Severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) is a beta-coronavirus that emerged as a global threat and caused a pandemic following its first outbreak in Wuhan, China, in late 2019. SARS-CoV-2 causes COVID-19, a disease ranging from relatively mild to severe illness. Older people and those with many serious underlying medical conditions such as diabetes, heart or lung conditions are at higher risk for developing severe complications from COVID-19 illness. SARS-CoV-2 infections of adults can lead to neurological complications ranging from headaches, loss of taste and smell, to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Herein we attempt to describe the neurological manifestations of SARS-CoV2 infection with a special focus on Guillain-Barré syndrome.

scholarly journals Guillain-Barré Syndrome associated with Chikungunya virus infection:

2019 ◽  
Vol 26 ◽  
pp. 1-8
Author(s):  
Diandra Caroline Martins ◽  
Marco Orsini ◽  
Adalgiza Mafra Moreno ◽  
Nélio Souza ◽  
Silmar Teixeira ◽  
...  
Keyword(s):  
Virus Infection ◽  
Chikungunya Virus ◽  
Neurological Diseases ◽  
Public Health Problem ◽  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Functional Impairments ◽  
Acute Inflammatory Demyelinating Polyneuropathy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Objective. The epidemic of infection by the Chikungunya virus currently represents one of the largest epidemiological occurrences in south and Central America, being considered a serious public health problem, since, in addition to the typical clinical symptomatology, there are reports of Associated neurological diseases, such as Guillain-Barré Syndrome. Guillain-Barré Syndrome is an acute inflammatory demyelinating polyneuropathy that leads to various functional impairments, such as flaccid paralysis, areflexia and muscular weakness. Method. A case of Guillain-Barré Syndrome was reported after infection by the chikungunya virus. Results. The case presented severe functional complications, with a picture of flaccid tetraparesis, with motor and sensory impairment, mainly in the left hemibody. Conclusion. From this perspective, from this report, and from reports of previous cases, it is considered that chikungunya virus infection may cause Guillain-Barré Syndrome, among other severe neurological complications, in an acute and progressive way, especially in areas considered endemic.

scholarly journals Unusual Presentation of COVID-19 Disease Leading to Respiratory Distress and Coma

2021 ◽  
Author(s):  
Julie Paradis ◽  
Hendrik Kevers ◽  
Soufiane Chebli ◽  
Serge Blum ◽  
Pascal Reper
Keyword(s):  
Respiratory Distress ◽  
Respiratory Insufficiency ◽  
Neurological Complications ◽  
Asymptomatic Infection ◽  
Unusual Presentation ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Critical Situations ◽  
At Home

Multiple neurological complications including Guillain-Barré syndrome (GBS) have been associated with COVID-19. We describe a case of GBS related to SARS-CoV-2 infection with an unusual presentation beginning with mobilization problems at home without previous classic respiratory or general manifestations. Asymptomatic infection with COVID-19 can lead to critical situations with respiratory insufficiency because of neurological complications such as GBS.

scholarly journals Guillain-Barre syndrome related to COVID-19: muscle and nerve biopsy findings

2021 ◽  
Vol 31 (3) ◽  
pp. 465-469
Author(s):  
Dandara Costa Lima de Souza ◽  
Rafael Basílio Guimarães ◽  
Alzira De Siqueira Carvalho
Keyword(s):  
Peripheral Nerve ◽  
Nerve Biopsy ◽  
Neurological Complications ◽  
Guillain Barre Syndrome ◽  
Morphological Aspects ◽  
Guillain Barré Syndrome ◽  
Respiratory Discomfort ◽  
Guillain Barré ◽  
Inflammatory Infiltrates ◽  
Muscle Biopsies

Background: The involvement of the peripheral nervous system (PNS) in COVID-19 is rare and, to date, morphological aspects from muscle and nerve biopsies have not been reported. Here, we describe a case of Guillain-Barré Syndrome (GBS) related to COVID-19 and demonstrate findings from peripheral nerve and skeletal muscle biopsies. A 79-year-old man presented with progressive weakness in both legs over one-week, evolving to both arms and urinary retention within 6 days. Four days earlier, he had a cough, febrile sensation and mild respiratory discomfort. On admission, his was afebrile, and without respiratory distress. A neurological examination disclosed asymmetric proximal weakness, diminished reflexes and no sensitive abnormalities. Three days later, the patient presented with bilateral facial weakness and proximal muscle strength worsened. Deep tendon reflexes and plantar responses were absent. Both superficial and profound sensitivity were decreased. From this point, oxygen saturation worsened, and the patient was placed on mechanical ventilation. CSF testing revealed one cell and protein 185 mg/dl. A chest CT showed the presence of ground-glass opacities and RT-PCR for SARS-CoV-2 was positive. The muscle biopsy revealed moderate neuromyopathic findings with positive expression for MHC-class I, C5b9, CD8 and CD68. The nerve biopsy showed inflammatory infiltrates predominantly with endoneurial compound formed by CD45 and CD68. The patient was treated with Oseltamivir for 9 days followed by IVIG for 5 days and died three days later of septic shock. Discussion: This is the first documented case of GBS associated with COVID-19 with a muscle and nerve anatomopathological study. A systematic review about neurological complications caused by COVID-19 described 11 patients with GBS. The morphological features reported in our patient showed signs of involvement of the immune system, suggesting that direct viral invasion could have played a role in the pathogenesis of peripheral nerve injury. Hereafter, further research will be necessary to understand the triggers for these cells migrating into the peripheral nerve.

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