scholarly journals Non-Islet Cell Tumor Hypoglycemia Caused by Recurrent Pelvic Solitary Fibrous Tumor

Cureus ◽  
2021 ◽  
Author(s):  
Diana Pinho dos Santos ◽  
Rui Correia ◽  
Adelino Carragoso ◽  
Carlos Casimiro ◽  
Ana Lemos
Keyword(s):  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

Solitary Fibrous Tumor Associated With Non-Islet Cell Tumor Hypoglycemia

2007 ◽  
Vol 84 (1) ◽  
pp. 292-294 ◽  
Author(s):  
Kotaro Kameyama ◽  
Norihito Okumura ◽  
Yujiro Kokado ◽  
Kentaroh Miyoshi ◽  
Tomoaki Matsuoka ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

scholarly journals Late Onset of Non-islet Cell Tumor Hypoglycemia Managed via Multidisciplinary Treatment in a Patient with a Solitary Fibrous Tumor

2018 ◽  
Vol 57 (16) ◽  
pp. 2431-2436 ◽  
Author(s):  
Satoshi Takeuchi ◽  
Tomohiro Goda ◽  
Jun Taguchi ◽  
Yuichi Douhata ◽  
Rio Honma ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Late Onset ◽  
Islet Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Cell Tumor ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

scholarly journals Intra-Abdominal Solitary Fibrous Tumor secretes high molecular weight IGF-II, causing Hypoglycemia

2020 ◽  
Vol 5 (5) ◽  
Keyword(s):  
Molecular Weight ◽  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Spindle Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

Hypoglycemia is a common event that has many well-known causes. Nevertheless, Non-islet cell tumor hypoglycemia (NICTH) is not one of them. As a matter of fact, NICTH is a rare but serious paraneoplastic syndrome. Solitary Fibrous tumor (SFT) is a rare spindle cell neoplasm derived from mesenchymal cells that in just 5% of cases releases “The Big” Insulin-like Growth Factor (IGF) II leading to hypoglycemic events [1].

scholarly journals Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: a case report

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Masahiro Kitada ◽  
Shunsuke Yasuda ◽  
Nana Takahashi ◽  
Satoshi Okazaki ◽  
Kei Ishibashi ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

scholarly journals A Case of Non-islet Cell Tumor Hypoglycemia with Malignant Solitary Fibrous Tumor of the Pleura

Haigan ◽  
2013 ◽  
Vol 53 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Youko Kataoka ◽  
Mayumi Oshio ◽  
Tomoyuki Igarashi ◽  
Makoto Motoishi ◽  
Satoru Sawai ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

scholarly journals A Case of Non-Islet Cell Tumor Hypoglycemia in Metastatic Solitary Fibrous Tumor

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A1035-A1036
Author(s):  
Lakshmi Priyanka Mahali ◽  
Beatrice Wong
Keyword(s):  
Blood Glucose ◽  
Growth Factor ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Serum Glucose ◽  
Capillary Blood ◽  
Cell Tumor ◽  
Capillary Blood Glucose ◽  
Fibrous Tumor ◽  
Tumor Hypoglycemia

Abstract Introduction: Insulin like growth factor (IGF-2) mediated hypoglycemia secondary to solitary fibrous tumor (SFT), also known as Doege-Potter syndrome is a rare paraneoplastic syndrome. The tumor cells produce large amounts of high molecular weight IGF 2 precursor protein called “big IGF-2” which binds to insulin and IGF receptors in liver, muscle and other peripheral tissues. This causes reduced gluconeogenesis and increased uptake of glucose by the muscle and other tissues leading to hypoglycemia. Big IGF-2 also exerts central negative feedback of growth hormone causing reduction of IGF-I production. Most SFTs are benign and localized (approximately 78-88%). As a result, tumor excision alone would often lead to resolution of the hypoglycemia. We present a case of metastatic SFT with multiple metastasis managed with oral prednisone. Clinical Case: A 44-year-old man with metastatic SFT presented with bilateral humeral fractures. He has known metastatic disease to the brain, lung, liver, bony lytic lesions over a course of eleven years. It has progressed despite multiple chemotherapy and radiation therapies. Prior to admission, he had multiple syncopal episodes associated with fasting hypoglycemia. He reported capillary blood glucose values ranging between 30-50 mg/dl during these episodes which would improve after drinking juice or eating candy. There was no history of diabetes mellitus or use of oral hypoglycemic agents or insulin. On admission, he had a capillary blood glucose value of less than 20 mg/dl, which was confirmed by a serum glucose value of 18 mg/dl on basic metabolic panel. His renal, liver and thyroid function tests were normal. Significant labs include: serum glucose 17 mg/dl, C-peptide <0.10 ng/ml (n: 1-4 ng/ml), serum insulin <1.6 Uu/ml (n: <20 Uu/ml), beta-hydroxybutyrate <0.2 mmol/L (n: <0.3), cortisol 10.8 ug/dl(n: 5-15 ug/dl) glucagon 6 pg/ml(ref 8-57 pg/ml), insulin-like growth factor-1 (IGF 1) 20 ng/ml (n: 52-328), and IGF-2 level 380 ng/ml (267-616 ng/ml), improvement in blood glucose from 46 to 111 mg/dl after 1-gram glucagon administration. The IGF-2/IGF-1 ratio of 19 confirmed our clinical suspicion of non-islet cell tumor hypoglycemia (NICTH). He was started on prednisone 20 mg twice daily with marked improvement in hypoglycemia. Conclusion: NICTH is a rare cause of hypoglycemia and should be considered in the differential while evaluating hypoglycemia in malignancy. For diagnosing NICTH, assays for big IGF-II are not commercially available. However, the IGF-II:IGF-I ratio is considered to be a surrogate marker of big IGFII concentration. The normal ratio is 3 and ratio >10 is diagnostic of NICTH. In cases like ours where tumor resection is not possible, glucocorticoids are most effective in management of hypoglycemia by inhibiting big IGF2 production and stimulating gluconeogenesis.

scholarly journals A Rapid Method for Analyzing Serum Pro-Insulin-Like Growth Factor-II in Patients with Non-Islet Cell Tumor Hypoglycemia

2005 ◽  
Vol 90 (7) ◽  
pp. 3819-3823 ◽  
Author(s):  
Farideh Miraki-Moud ◽  
Ashley B. Grossman ◽  
Michael Besser ◽  
John P. Monson ◽  
Cecilia Camacho-Hübner
Keyword(s):  
Growth Factor ◽  
Rapid Method ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Tumor Hypoglycemia

Non-Islet Cell Tumor Hypoglycemia Associated with Uterine Leiomyomata

2011 ◽  
Vol 17 (4) ◽  
pp. e109-e112 ◽  
Author(s):  
Albert Ndzengue ◽  
Zwege Deribe ◽  
Richard Rafal ◽  
Maximo Mora ◽  
Schiller Desgrottes ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Uterine Leiomyomata ◽  
Tumor Hypoglycemia
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