scholarly journals Bilateral Pulmonary Embolism in a Newly Diagnosed Case of Pulmonary Tuberculosis

Cureus ◽  
2021 ◽  
Author(s):  
Urooj Zahra ◽  
Ali Akhtar ◽  
Noor Ul Falah ◽  
Shahnawaz Hashmi
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Tuberculosis ◽  
Newly Diagnosed

Influence of the Acetylation Type on the Incidence of Isoniazid-Induced Hepatotoxicity in Patients with Newly Diagnosed Pulmonary Tuberculosis

2020 ◽  
Vol 65 (7-8) ◽  
pp. 31-36
Author(s):  
N. M. Krasnova ◽  
N. E. Evdokimova ◽  
A. A. Egorova ◽  
O. I. Filippova ◽  
E. A. Alekseeva ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Clinical Laboratory ◽  
Clinical Manifestations ◽  
Normal Activity ◽  
Slow Acetylators ◽  
Nucleotide Polymorphisms ◽  
Newly Diagnosed ◽  
Single Nucleotide ◽  
Tuberculosis Chemotherapy ◽  
Genetically Determined

Introduction. Liver damage can be a dangerous side effect of using isoniazid. Individual susceptibility to isoniazid in humans is dependent on the presence of N-acetyltransferase 2 allelic variants in genome. It was imperative to assess the effect of genetically determined isoniazid acetylation rate in terms of risk of developing isoniazid-induced hepatotoxicity, as well as prevention of potential hepatopathy, and improvement of tuberculosis chemotherapy safety. Aim. To study the effect of acetylation type on the incidence of isoniazid hepatotoxicity in residents of the Sakha Republic (Yakutia) with newly diagnosed pulmonary tuberculosis. Methods. The study included 112 patients with newly diagnosed pulmonary tuberculosis. Genotyping was performed using real-time polymerase chain reaction. The following single nucleotide polymorphisms were studied: rs1801280, rs1799930, rs1799931, rs1799929, rs1208, rs1041983. Hepatotoxicity was determined based on the results of clinical laboratory monitoring and using the criteria developed by the European Association for the Study of the Liver (2019). Results. Hepatotoxic reactions developed more often in slow acetylators (43.2%), compared to fast acetylators (20.7%) and intermediate acetylators (10.9%); p=0.002. Serum alanine aminotransferase activity was 5 or more times above the upper limit of normal activity in 37.8% of slow acetylators, and in 8.7% of intermediate acetylators; p=0.001. Clinical manifestations of isoniazid hepatotoxicity were observed more often in slow acetylators (29.7%), than in fast acetylators (3.4%); p=0.000. Conclusion. Slow acetylation type ought to be considered an important risk factor for developing isoniazid hepatotoxicity in patients with pulmonary tuberculosis.

scholarly journals A case of concomitant pulmonary embolism and pulmonary tuberculosis in the era of COVID 19, a matter of cautious approach

2021 ◽  
Author(s):  
Sinda Dakhlia ◽  
Phool Iqbal ◽  
Muhammad Abubakar ◽  
Sabeen Zara ◽  
Muhammad Murtaza ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Tuberculosis ◽  
Cautious Approach

Polymorphisms of interleukin-10 and tumour necrosis factor-? genes are associated with newly diagnosed and recurrent pulmonary tuberculosis

Respirology ◽  
2007 ◽  
Vol 12 (4) ◽  
pp. 594-598 ◽  
Author(s):  
Jae-Hee OH ◽  
Chul-Su YANG ◽  
Yeon-Kyeong NOH ◽  
Yu-Mi KWEON ◽  
Sung-Soo JUNG ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Interleukin 10 ◽  
Newly Diagnosed ◽  
Necrosis Factor

scholarly journals The most significant reasons for the failure of treatment of patients with newly diagnosed pulmonary tuberculosis and possible solutions

2020 ◽  
pp. 35-42
Author(s):  
M.M. Kuzhko ◽  
T.V. Tlustova ◽  
D.O. Butov ◽  
M.I. Gumeniuk ◽  
L.M. Protsyk ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Blood Serum ◽  
Maximum Concentration ◽  
Gastrointestinal System ◽  
Newly Diagnosed ◽  
Antituberculosis Drugs ◽  
Treatment Regimens ◽  
Drugs In Blood ◽  
New Treatment ◽  
System Tract

ABSTRACT. The paper summarizes the results of studies regarding the most significant causes of ineffective treatment of patients with newly diagnosed pulmonary tuberculosis. It is proven that the effectiveness of treatment depends from the maximum concentration of antituberculosis drugs in blood serum, tissues and foci of affected lungs, depending on the method of administration of drugs and the presence of concomitant pathology from hepatobiliary and gastrointestinal system tract. Recommendations are given regarding the prevention of ineffective treatment of patients with pulmonary tuberculosis by improving diagnosis and developing new treatment regimens.

scholarly journals Biological microchips for detection of multiple drug resistant M. tuberculosis strains isolated in Kyrgyz Republic

2008 ◽  
pp. 64-66
Author(s):  
J. T. Isakova ◽  
Z. K. Goncharova ◽  
A. A. Aldashev
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Gene Mutations ◽  
Rpob Gene ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Kyrgyz Republic ◽  
Newly Diagnosed ◽  
Single Drug ◽  
Multiple Drug Resistant

The aim of the study was to estimate spread of primary and secondary multiple drug resistant Mycobacterium tuberculosis (MBT) and to characterize rpoB, katG, inhA, and ahpC gene mutations of rifampicin (RIF) and isoniazid (INH) resistant MBT strains isolated from tuberculosis patients in Kyrgyz. We obtained 493 specimens from patients with pulmonary tuberculosis which were diagnosed based on clinical, X-ray, and bacteriological examination. Among them, newly diagnosed pulmonary tuberculosis was in 445 patients (90.2 %), and 48 of the patients (9.8 %) have already been treated for tuberculosis. Mutations of rpoB, KatG, inhA, and ahpC genes associated with RIF and INH resistance were detected by biological chip test. Sensitive MBT strains were detected in 47 % and resistant strains were in 53 % of the newly diagnosed patients. Single-drug resistance to RIF only was detected in 3 % of cases; resistance to INH was found in 20 %, resistance to both the drugs was detected in 30 % of the patients. In pre-treated patients single-drug resistance to RIF was defined in 4 % of cases, resistance to INH was in 8 %, resistance to both the drugs was estimated in 75 % of the patients. Therefore, we suppose that there is a high prevalence of multi-drug resistant MBT in Kyrgyz Republic: 30 % among newly diagnosed patients and 75 % among pre-treated patients. The main cause of RIF-resistance of MBT is Ser531→Leu mutation of rpoB gene, and the main cause of INHresistance is Ser315→Thr mutation of katG gene.

scholarly journals A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Mahshid Aryanpur ◽  
Mostafa Hosseini ◽  
Mohammad Reza Masjedi ◽  
Esmaeil Mortaz ◽  
Payam Tabarsi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Smoking Cessation ◽  
Pulmonary Tuberculosis ◽  
Controlled Trial ◽  
Newly Diagnosed ◽  
Randomized Controlled

Study of spectrum of fungal isolates in the sputum of newly diagnosed pulmonary tuberculosis patients

2021 ◽  
pp. 004947552110546
Author(s):  
Abdul Raouf Wani ◽  
Lokender Kumar ◽  
Ritu Singhal ◽  
Amartya Chakraborti ◽  
Sagar Mohanrao Khot
Keyword(s):  
Pulmonary Tuberculosis ◽  
Significant Proportion ◽  
Fungal Culture ◽  
Newly Diagnosed ◽  
Candida Spp ◽  
Duration Of Symptoms ◽  
Fungal Colonisation ◽  
Fungal Isolates ◽  
Low Body Mass Index ◽  
Independent Risk Factors

Tuberculosis is a state of immunosupression which exposes the patients to further opportunistic pathogens like fungus. Methods: 102 newly diagnosed sputum positive pulmonary tuberculosis cases were enrolled. Significant fungal isolates were seen in 31/102 (30.4%) patients. Aspergillus spp. were isolated in 13/31(41.9%) of the positive fungal cultures while Candida spp. were isolated in 15/31 (48.4%). Low body mass index, duration of symptoms, haemoptysis, severity of radiological features and IgG Aspergillus antibodies were independent risk factors for positive fungal culture. Significant proportion of patients with PTB have fungal colonisation of their airways which can lead to poor clinical outcomes. Few easily ascertained clinical parameters can help the clinician to determine patients who are at a higher risk of fungal colonisation.

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