scholarly journals Low Absolute Eosinophil Count Predicts In-Hospital Mortality in Cirrhosis With Systemic Inflammatory Response Syndrome

Cureus ◽  
2021 ◽  
Author(s):  
Varsha Wilson ◽  
Kunnothara Kantan Velayudhan ◽  
Harshavardhan Rao ◽  
Sheejamol Velickakathu Sukumaran
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Hospital Mortality ◽  
Eosinophil Count ◽  
Systemic Inflammatory Response ◽  
Absolute Eosinophil Count

Comparative study of the performance of SOFA and qSOFA versus SIRS criteria for predicting mortality among septic patients admitted to the intensive care unit

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Naglaa Mohammad Aly ◽  
Mustafa Mansour Hussein ◽  
Mohammad Mohammad Kamal Abd Allah ◽  
Mustafa Youssef Abd-El Magid
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Hospital Mortality ◽  
Comparative Study ◽  
Sofa Score ◽  
Systemic Inflammatory Response ◽  
Suspected Infection ◽  
Sirs Criteria

Abstract Background Sepsis is considered one of a life-threatening condition among intensive care unit (ICU) patients. Although, there are evidence-based management guidelines, sepsis still remains a leading cause of death with in-hospital mortality ranging from 22.8% to 48.7%. Previously sepsis was defined as systemic inflammatory response to infection, which could be diagnosed by meeting two or more Systemic Inflammatory Response Syndrome (SIRS) criteria, along with a known or suspected infection. Even though the SIRS criteria were sensitive, but they were not specific enough to differentiate between sepsis and other inflammatory conditions. Objective To compare between the ability of SOFA score, the quick SOFA (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) to predict ICU mortality. Patients and Methods Randomized prospective comparative study conducted in El Haram Specialized Hospital. The study included 75 patients. We calculated SOFA, SIRS, and qSOFA scores based on physiological and laboratory data that were collected upon admission to the ICU. Standard criteria were applied with a threshold of 2 or more points for each scoring system. The baseline SOFA score was assumed to be zero for patients without a known preexisting organ dysfunction. The baseline total SOFA score was considered to be 4 for patients undergoing chronic dialysis, and 2 or 3 for cirrhotic patients, depending on baseline bilirubin levels. Results ROC curve analysis between survival and each of SIRS, qSOFA and SOFA, it shows that SOFA score presented the best discrimination with an AUC of 0.993 (95% CI 0.981–100). Conclusion In patients with suspected infection admitted to an ICU, an increase in SOFA score had greater prognostic accuracy for in-hospital mortality than SIRS criteria or qSOFA. These findings suggest that SIRS and qSOFA may have limited use for predicting mortality in an ICU setting.

scholarly journals Diabetic Foot Infection Presenting Systemic Inflammatory Response Syndrome: A Unique Disorder of Systemic Reaction from Infection of the Most Distal Body

2019 ◽  
Vol 8 (10) ◽  
pp. 1538 ◽  
Author(s):  
Cheng-Wei Lin ◽  
Shih-Yuan Hung ◽  
Chung-Huei Huang ◽  
Jiun-Ting Yeh ◽  
Yu-Yao Huang
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Hospital Mortality ◽  
Diabetic Foot ◽  
Poor Prognosis ◽  
Systemic Inflammatory Response ◽  
The Body ◽  
Clinical Factors ◽  
Diabetic Foot Infection ◽  
Grade 3

Diabetic foot infection (DFI) is a major complication of diabetic foot that lead to nontraumatic lower-extremity amputation (LEA). Such distal infection of the body having systemic inflammatory response syndrome (SIRS) is rarely reported. Consecutive patients treated for limb-threatening DFI in a major diabetic foot center in Taiwan were analyzed between the years 2014 to 2017. Clinical factors, laboratory data, perfusion, extent, depth, infection and sensation (PEDIS) wound score in 519 subjects with grade 3 DFI and 203 presenting SIRS (28.1%) were compared. Major LEA and in-hospital mortality were defined as poor prognosis. Patients presenting SIRS had poor prognosis compared with those with grade 3 DFI (14.3% versus 6.6% for major LEA and 6.4% versus 3.5% for in-hospital mortality). Age, wound size, and HbA1c were independent risk factors favoring SIRS presentation. Perfusion grade 3 (odds ratio 3.37, p = 0.044) and history of major adverse cardiac events (OR 2.41, p = 0.036) were the independent factors for poor prognosis in treating patients with DFI presenting SIRS. SIRS when presented in patients with DFI is not only limb- but life-threatening as well. Clinicians should be aware of the clinical factors that are prone to develop and those affecting the prognosis in treating patients with limb-threatening foot infections.

scholarly journals The prognostic accuracy of systemic inflammatory response syndrome, quick sequential organ failure assessment and sequential organ failure assessment scores in estimating the 28 day in-hospital mortality

2020 ◽  
Vol 8 (1) ◽  
pp. 45
Author(s):  
Malli Dorasanamma ◽  
Nikhil Nagireddi ◽  
Keerthana Bathyala
Keyword(s):  
Length Of Stay ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Hospital Mortality ◽  
Sequential Organ Failure Assessment ◽  
Organ Failure ◽  
General Medicine ◽  
Systemic Inflammatory Response ◽  
Prognostic Accuracy ◽  
Failure Assessment

Background: Sepsis is among the leading causes of death in the world. 31.5 million cases of sepsis and 19.4 million cases of septic shock have been the annual global incidence. The collaborative efforts have improved the outcomes, yet the in-hospital mortality rates remain high. This study is undertaken to ascertain the prognostic accuracy of systemic inflammatory response syndrome (SIRS), quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA) scores in estimating the in-hospital mortality.Methods:  A prospective observational study was done from the department of general medicine and intensive care units from December 2017 to September 2019. A total of 50 Sepsis patients were selected for the study. The patients have been monitored for 28 days. Data regarding demographics, illness severity, organ dysfunction, length of stay and outcome (for 28 days) of the patients are noted.Results: The SOFA score with AUROC of 0.82, had the best discrimination in predicting mortality.Conclusions: SOFA has better prognostic accuracy than SIRS and qSOFA in predicting mortality. As ICU mortality is high in this group and care should be resource-intensive due to increased length of stay.

Systemic inflammatory response syndrome after major abdominal surgery

2019 ◽  
pp. 113-116
Author(s):  
Abdullah AlSomali ◽  
Abdullah Mobarki ◽  
Mohammed Almuhanna ◽  
Abdullah Alqahtani ◽  
Ziyad Alhawali ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Abdominal Surgery ◽  
Systemic Inflammatory Response ◽  
Major Abdominal Surgery
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