scholarly journals Atypical Neuroleptic Malignant Syndrome in the Setting of Quetiapine Overdose: A Case Report and Review of the Literature

Cureus ◽  
2021 ◽  
Author(s):  
Sheila D Hernandez ◽  
Dario A Marotta ◽  
Ravitej Goteti
1986 ◽  
Vol 31 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Margaret Schibuk ◽  
Debbie Schachter

The authors present a case report in which an agitated response to antidepressants preceded the neuroleptic malignant syndrome (NMS). In a review of 64 cases of NMS in the literature, they found that 80% were described as agitated prior to the development of the syndrome. Polypharmacy was common. A review of the literature on theories of pathogenesis involving sympathetic amines other than dopamine is presented to explain this phenomena. It is suggested that these toxic reactions to medication can be interpreted as resulting from a relative NE/DA excess, in which antidepressants increase the numerator, while neuroleptics functionally decrease the denominator. It is recommended that where an agitated response to antidepressants is observed, neuroleptics should be used only with considerable caution.


2008 ◽  
Vol 32 (8) ◽  
pp. 1998-1999 ◽  
Author(s):  
Lai Gwen Chan ◽  
Jimmy Lee ◽  
Boon Tat Ng ◽  
Ee Lian Lee ◽  
Hong Choon Chua ◽  
...  

2019 ◽  
Vol 43 ◽  
pp. 7-8 ◽  
Author(s):  
Favaz Vellekkatt ◽  
Pooja Patnaik Kuppili ◽  
Balaji Bharadwaj ◽  
Vikas Menon

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Arash Kazemi ◽  
Sabahat Lavvaf ◽  
Marzieh Azizi ◽  
Mahboobeh Shirzad ◽  
Forouzan Elyasi ◽  
...  

2021 ◽  
Vol 9 ◽  
pp. 232470962110297
Author(s):  
Ryan Serdenes ◽  
Samuel Orr ◽  
Pamela Trio ◽  
Seetha Chandrasekhara ◽  
Meghan Musselman

In this report, we describe a case of atypical neuroleptic malignant syndrome (NMS) presenting with an isolated lesion in the splenium of the corpus callosum (ILSCC). There is a paucity of information regarding this topic within the literature and only 7 previous case reports have been published at the time of writing. To our knowledge, this case report is also the first to describe an atypical NMS variant in the context of an ILSCC. In this report, we describe the important considerations in formulating differential diagnosis for ILSCC and are the first report to propose a possible pathophysiological mechanism relating ILSCC with NMS.


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