scholarly journals Kidney Recovery From Acute Kidney Injury After Hematopoietic Stem Cell Transplant: A Systematic Review and Meta-Analysis

Cureus ◽  
2021 ◽  
Author(s):  
Swetha Rani Kanduri ◽  
Karthik Kovvuru ◽  
Wisit Cheungpasitporn ◽  
Charat Thongprayoon ◽  
Tarun Bathini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem Cell Transplant ◽  
Stem Cell Transplant ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Cell Transplant ◽  
Hematopoietic Stem

scholarly journals Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant

2014 ◽  
Vol 55 (12) ◽  
pp. 2866-2873 ◽  
Author(s):  
Camille R. Petri ◽  
Peter H. O’Donnell ◽  
Hongyuan Cao ◽  
Andrew S. Artz ◽  
Wendy Stock ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem Cell Transplant ◽  
Stem Cell Transplant ◽  
Kidney Injury ◽  
Cell Transplant ◽  
Hematopoietic Stem

scholarly journals Incidence and mortality of acute kidney injury in patients undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis

QJM ◽  
2020 ◽  
Vol 113 (9) ◽  
pp. 621-632 ◽  
Author(s):  
S R Kanduri ◽  
W Cheungpasitporn ◽  
C Thongprayoon ◽  
T Bathini ◽  
K Kovvuru ◽  
...  
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Mortality Risk ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Incidence And Mortality

Abstract Background While acute kidney injury (AKI) is commonly reported following hematopoietic stem cell transplant (HCT), the incidence and impact of AKI on mortality among patients undergoing HCT are not well described. We conducted this systematic review to assess the incidence and impact of AKI on mortality risk among patients undergoing HCT. Methods Ovid MEDLINE, EMBASE and the Cochrane Databases were searched from database inceptions through August 2019 to identify studies assessing the incidence of AKI and mortality risk among adult patients who developed AKI following HCT. Random-effects and generic inverse variance method of DerSimonian–Laird were used to combine the effect estimates obtained from individual studies. Results We included 36 cohort studies with a total of 5144 patients undergoing HCT. Overall, the pooled estimated incidence of AKI and severe AKI (AKI Stage III) were 55.1% (95% confidence interval (CI) 46.6–63.3%) and 8.3% (95% CI 6.0–11.4%), respectively. The pooled estimated incidence of AKI using contemporary AKI definitions (RIFLE, AKIN and KDIGO criteria) was 49.8% (95% CI 41.6–58.1%). There was no significant correlation between study year and the incidence of AKI (P = 0.12) or severe AKI (P = 0.97). The pooled odds ratios of 3-month mortality and 3-year mortality among patients undergoing HCT with AKI were 3.05 (95% CI 2.07–4.49) and 2.23 (95% CI 1.06–4.73), respectively. Conclusion The incidence of AKI among patients who undergo HCT remains high, and it has not changed over the years despite advances in medicine. AKI after HCT is associated with increased short- and long-term mortality.

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