scholarly journals A Retrospective Cohort Study to Assess Patient and Physician Reported Outcome Measures After Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Stroke

Cureus ◽  
2017 ◽  
Author(s):  
Sanjay Budhdeo ◽  
Angelos G Kolias ◽  
David J Clark ◽  
Aswin Chari ◽  
Peter J Hutchinson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Middle Cerebral Artery ◽  
Outcome Measures ◽  
Cerebral Artery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke

scholarly journals Fuchs endothelial corneal dystrophy and small eyes

2020 ◽  
Vol 17 (1) ◽  
pp. 35-40
Author(s):  
Nicole Shao-Yuen Lim ◽  
John Males
Keyword(s):  
Cohort Study ◽  
Outcome Measures ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Strong Association ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Corneal Dystrophy ◽  
T Test ◽  
Corneal Decompensation

Aim: To determine whether there is an association between Fuchs endothelial corneal dystrophy (FECD) and shorter axial length (AL), shallower anterior chamber depth (ACD) and higher spherical equivalent (SE). In addition, to evaluate whether there is a correlation between AL and severity of corneal decompensation in FECD, using corneal thickness as a proxy. Design: Retrospective cohort study. Methods: This was a single-centre study conducted in a cornea clinic in Sydney, Australia. Detailed clinical measurements of 91 eyes of 50 FECD patients were compared with 110 eyes of 55 controls. Main outcome measures included AL, ACD and SE. Other outcome measures included central corneal thickness, visual acuity, intraocular pressure and keratometry. Results: Mean AL of FECD patients was 23.6 mm (standard deviation [SD] ±0.9 mm), compared with 24.7 mm (SD ±1.8 mm) for controls (1.1 mm difference [95% confidence interval [CI] 0.5-1.6], p < 0.001, independent sample t-test); corresponding means for ACD were 3.0 and 3.3 mm (0.32 mm difference [95%CI 0.2-0.5], p < 0.001, independent t-test). Eleven out of the 22 FECD patients with available refraction data had hypermetropic refraction compared with 16 out of 36 controls (p = 0.68, chi-squared test). The mean SE of FECD patients (+0.10D) was higher than controls (−1.33D) (1.4D difference [0.1-2.8], p = 0.04, independent t-test). No statistically significant correlation was found between AL and corneal thickness (p = 0.28, linear regression). Conclusion: In this retrospective cohort study, a strong association was established between FECD and small eyes, with shorter AL and shallower ACD, compared with controls. These results have important implications for surgical planning, as shorter AL and ACD in FECD patients likely contribute to their high risk of corneal decompensation following cataract surgery.

scholarly journals Factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients: a retrospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e052609
Author(s):  
Jianbo Shao ◽  
Hong Xu ◽  
Zhixi Liu ◽  
Xiaohua Ying ◽  
Hua Xu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Outcome Measures ◽  
Clinical Features ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Antiviral Drugs ◽  
Secondary Outcome ◽  
Rt Pcr ◽  
Factors Associated ◽  
Paediatric Patients

ObjectiveThis study aimed to describe the epidemiological and clinical features and potential factors related to the time to return negative reverse transcriptase (RT)-PCR in discharged paediatric patients with COVID-19.DesignRetrospective cohort study.SettingUnscheduled admissions to 12 tertiary hospitals in China.ParticipantsTwo hundred and thirty-three clinical charts of paediatric patients with confirmed diagnosis of COVID-19 admitted from 1 January 2020 to 17 April 2020.Primary and secondary outcome measuresPrimary outcome measures: factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients. Secondary outcome measures: epidemiological and clinical features and laboratory results in paediatric patients.ResultsThe median age of patients in our cohort was 7.50 (IQR: 2.92–12.17) years, and 133 (57.1%) patients were male. 42 (18.0%) patients were evaluated as asymptomatic, while 162 (69.5%) and 25 (10.7%) patients were classified as mild or moderate, respectively. In Cox regression analysis, longer time to negative RT-PCR was associated with the presence of confirmed infection in family members (HR (95% CI): 0.56 (0.41 to 0.79)). Paediatric patients with emesis symptom had a longer time to return negative (HR (95% CI): 0.33 (0.14 to 0.78)). During hospitalisation, the use of traditional Chinese medicine (TCM) and antiviral drugs at the same time is less conducive to return negative than antiviral drugs alone (HR (95% CI): 0.85 (0.64 to 1.13)).ConclusionsThe mode of transmission might be a critical factor determining the disease severity of COVID-19. Patients with emesis symptom, complications or confirmed infection in family members may have longer healing time than others. However, there were no significant favourable effects from TCM when the patients have received antiviral treatment.

scholarly journals Effect of COVID-19 vaccination on menstrual periods: a retrospective cohort study

2021 ◽  
Author(s):  
Victoria Male
Keyword(s):  
Cohort Study ◽  
Menstrual Cycle ◽  
Outcome Measures ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hormonal Contraception ◽  
Menstrual Period ◽  
Study Setting

Objective. Clinicians and regulators are receiving reports of changes to menstrual periods following COVID-19 vaccination. However, it is unclear if the two are biologically linked. If they are, people using hormonal contraception are predicted to be less likely to report a change and spontaneously cycling people vaccinated prior to ovulation more likely. The objective was to test these hypotheses. Design. Retrospective cohort study. Setting. UK. Population. 1273 people who had received at least one dose of a COVID-19 vaccination, have periods or withdrawal bleeds and keep a record of the dates of these. Methods. Participants reported whether they use any hormonal contraception and, for each dose of the vaccine, on which day of their menstrual cycle they were vaccinated and details of how the timing and flow of their next period compared to their normal experience. Main outcome measures. Association between 1. the use of hormonal contraception and reported changes to timing or flow of the next menstrual period, and 2. the timing of vaccination within the menstrual cycle and reported changes to timing or flow of the next menstrual period. Results. The data from this cohort did not support the pre-specified hypotheses that people using hormonal contraception would be less likely to report a change, or that spontaneously cycling people vaccinated prior to ovulation would be more likely to report a change. Conclusions. This study did not detect strong signals supporting the idea that COVID-19 vaccination is linked to menstrual changes in most people. Funding. No specific funding.

Seizures and epilepsy after decompressive hemicraniectomy for malignant middle cerebral artery stroke

2017 ◽  
Vol 381 ◽  
pp. 336 ◽  
Author(s):  
M. Bianchin ◽  
R. Brondani ◽  
A. de Almeida ◽  
P. Cherubini ◽  
S. Mota ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke

scholarly journals Malignant middle cerebral artery syndrome with thrombotic thrombocytopenia following vaccination against SARS-CoV-2

2021 ◽  
pp. 175114372110274
Author(s):  
Carmen Jacob ◽  
Khairil Amir Rani ◽  
Patrick James Holton ◽  
Sara Rosalind Boyce ◽  
Nicolas Ulrick Weir ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Perioperative Complications ◽  
Rare Condition ◽  
Intravenous Immunoglobulins ◽  
Care Staff ◽  
Heparin Induced Thrombocytopenia ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke ◽  
Venous Thromboses

Cases of thromboses at unusual sites with thrombocytopenia have been reported following vaccination against Sars-CoV-2. This new syndrome, christened vaccine-induced thrombotic thrombocytopenia (VITT), mainly results in venous thromboses. We report the case of a young woman with a right middle cerebral artery stroke following vaccination with ChAdOx1 nCoV-19. A diagnosis of VITT was made and platelet counts began to recover shortly after commencing treatment with argatroban, intravenous immunoglobulins and corticosteroids. On day 6 following admission, the patient deteriorated neurologically and decision made to proceed with decompressive hemicraniectomy. There were no perioperative complications and anticoagulation with argatroban was reinitiated on the first postoperative day. VITT is a rare condition resembling auto-immune heparin-induced thrombocytopenia. All critical care staff should be aware of the rare link between vaccination against SARS-CoV-2 and VITT and the need to rapidly commence both anticoagulation, using heparin alternatives, and immunomodulation.

Decompressive Hemicraniectomy for Middle Cerebral Artery Stroke: Indications and Perioperative Care

AORN Journal ◽  
2021 ◽  
Vol 114 (1) ◽  
pp. 34-46
Author(s):  
Beth Karasin ◽  
Monica Grzelak ◽  
Gina Rizzo ◽  
Tara Hardinge ◽  
Lauren Eskuchen ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Perioperative Care ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke

scholarly journals Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke

2019 ◽  
Vol 76 (5) ◽  
pp. 571 ◽  
Author(s):  
Hermann Neugebauer ◽  
Hauke Schneider ◽  
Julian Bösel ◽  
Carsten Hobohm ◽  
Sven Poli ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke

Predictors of decompressive hemicraniectomy in malignant middle cerebral artery stroke

2018 ◽  
Vol 42 (1) ◽  
pp. 175-181 ◽  
Author(s):  
Saadat Kamran ◽  
Abdul Salam ◽  
Naveed Akhtar ◽  
Atlantic D’soza ◽  
Ashfaq Shuaib
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Decompressive Hemicraniectomy ◽  
Middle Cerebral Artery Stroke
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