scholarly journals Oral Ethanol Treatment for Ethylene Glycol Intoxication

Cureus ◽  
2020 ◽  
Author(s):  
Misa Sasanami ◽  
Taihei Yamada ◽  
Takafumi Obara ◽  
Atsunori Nakao ◽  
Hiromichi Naito
Keyword(s):  
Ethylene Glycol ◽  
Ethanol Treatment ◽  
Ethylene Glycol Intoxication

scholarly journals A case of Oral Ethanol Treatment for Acute Ethylene Glycol Intoxication

2005 ◽  
Vol 13 (1) ◽  
pp. 92
Author(s):  
Seung Hee Lee ◽  
Deok-In Kim ◽  
Jeong Gu Kim ◽  
Kum Ho Yi ◽  
Joo-Han Lim ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Ethanol Treatment ◽  
Ethylene Glycol Intoxication

4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man

1986 ◽  
Vol 24 (6) ◽  
pp. 463-483 ◽  
Author(s):  
Frederic J. Baud ◽  
Chantal Bismuth ◽  
Robert Garnier ◽  
Martine Galliot ◽  
Alain Astier ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Ethylene Glycol Intoxication

Fatal ethylene glycol intoxication: Report of a case and review of the literature

1987 ◽  
Vol 54 (4) ◽  
pp. 289-295 ◽  
Author(s):  
M. R. Verrilli ◽  
C. L. Deyling ◽  
C. E. Pippenger ◽  
F. Van Lente ◽  
D. G. Vidt ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Review Of The Literature ◽  
Ethylene Glycol Intoxication

scholarly journals Ethylene glycol intoxication following brake fluid ingestion complicated with unilateral facial nerve palsy: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
B. M. D. B. Basnayake ◽  
A. W. M. Wazil ◽  
N. Nanayakkara ◽  
R. M. B. S. S. Mahanama ◽  
P. N. S. Premathilake ◽  
...  
Keyword(s):  
Case Report ◽  
Ethylene Glycol ◽  
Facial Nerve ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Brake Fluid ◽  
Fluid Ingestion ◽  
Ethylene Glycol Intoxication

scholarly journals The safety of ethanol infusions for the treatment of methanol or ethylene glycol intoxication: an observational study

CJEM ◽  
2012 ◽  
Vol 14 (05) ◽  
pp. 283-289 ◽  
Author(s):  
Mary Kate Wedge ◽  
Sabrina Natarajan ◽  
Christel Johanson ◽  
Rakesh Patel ◽  
Salmaan Kanji
Keyword(s):  
Adverse Events ◽  
Ethylene Glycol ◽  
A Priori ◽  
Median Number ◽  
Target Range ◽  
Therapeutic Drug ◽  
Case Report Form ◽  
Physical Restraints ◽  
Ottawa Hospital ◽  
Ethylene Glycol Intoxication

ABSTRACT Background: Methanol or ethylene glycol ingestion may result in significant morbidity or death without prompt treatment. Despite traditional and widespread use of intravenous ethanol as an antidote, its safety is not well described. An evaluation of the safety and ease of titrating ethanol infusions is necessary given the availability of an alternative antidote. Objective: To evaluate the safety and ease of titrating ethanol infusions for the treatment of methanol or ethylene glycol ingestion. Methods: We reviewed the hospital records of adults treated with ethanol at The Ottawa Hospital for methanol or ethylene glycol ingestion over a 9-year period. Using a standardized case report form, a single reviewer identified prespecified adverse events that developed after the start of ethanol therapy and classified dose adjustments during ethanol therapy as appropriate or inappropriate based on a priori criteria. Results: Forty-nine cases of methanol or ethylene glycol ingestion treated with ethanol were included in the analysis, of which 45 underwent hemodialysis, 38 were admitted to the intensive care unit, and 4 died. At least one adverse event was identified in 45 (92%) cases, including 35 (71%) with agitation requiring chemical or physical restraints and 10 (20%) with a depressed level of consciousness treated with intubation. The median number of ethanol concentration measurements per treatment course was 6 (range 0–24), of which only 27% were within the target range of 22 to 30 mmol/L and 47% were below. When measured concentrations were outside the target, the adjustment in ethanol dosing (or lack thereof) was deemed inappropriate 59% of the time, including 69% of the time during hemodialysis. Conclusion: Based on actual practice in a large academic centre, adverse events occur frequently with intravenous ethanol infusions, and ethanol titration is inefficient. The safety profile and therapeutic drug monitoring considerations for ethanol should be considered when choosing an antidote for methanol or ethylene glycol ingestion.

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