scholarly journals Rarest of the Rare Metastatic Tubulocystic Carcinoma of Kidney

Cureus ◽  
2020 ◽  
Author(s):  
Hira Yousuf ◽  
Shiyam Kumar ◽  
Mansour Al-Moundhri
Keyword(s):  
Tubulocystic Carcinoma

Expression of Aldo-keto-reductase 1B1 (AKR1B1) in tubulocytic carcinoma of kidney.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 507-507
Author(s):  
Yasuhiro Hashimoto ◽  
Toshikazu Tanaka ◽  
Atsushi Imai ◽  
Shingo Hatakeyama ◽  
Takahiro Yoneyama ◽  
...  
Keyword(s):  
Who Classification ◽  
Collecting Duct ◽  
Renal Medulla ◽  
Papillary Renal Cell Carcinoma ◽  
Low Grade ◽  
Normal Kidney ◽  
High Concentration ◽  
Duct Carcinoma ◽  
Collecting Duct Carcinoma ◽  
Tubulocystic Carcinoma

507 Background: Tubulocystic carcinoma of the kidney (TubCC) is a new entity of tumor not listed in the 2004 WHO classification. The tumor comprised tubules forming duct-like structures exhibiting hobnail change, and resembled collecting duct carcinoma (CDC) by immunostaining; thus, this tumor was named low grade CDC. Since then, similar tumors have been reportedly called tubulocystic carcinoma (TubCC)We explored the possibility whether Aldo-keto-reductase-1B1 (AKR1B1), osmoregulatory protein and abundant in collecting duct, can be used as a marker for the pathologic diagnosis of TubCC. Methods: We prepared anti-AKR1B1 monoclonal antibodies, examined expression of AKR1B1 protein in the human normal kidney. Immunohistochemical expressions of AKR1B1 was examined on normal kidney, 4 cases of TubCC, 10 cases of papillary renal cell carcinoma (pRCC), and 10 cases of invasive urothelial carcinoma (iUC). Results: AKR1B1 expression distributed preferentially in the renal medulla and not in the cortex, reflected by its high concentration in medulla (2.12 ±1.35 μg/mg) compared with cortex (0.13 ± 0.03 μg/mg). Immunohistochemically, AKR1B1 was strongly positive in 3 of 4 TubCC cases. AKR1B1 was negative in cases of either iUC or pRCC. Conclusions: Although the present study was small and preliminary, AKR1B1 may be a more specific and potentially useful marker for TubCC. [Table: see text]

scholarly journals Tubulocystic carcinoma of the kidney

2011 ◽  
Vol 22 (4) ◽  
pp. 157-159
Author(s):  
Shih-Hao Liu ◽  
Yen-Hwa Chang ◽  
Chin-Chen Pan
Keyword(s):  
Tubulocystic Carcinoma

Tubulocystic Carcinoma of the Kidney

2011 ◽  
Vol 185 (6) ◽  
pp. 2348-2349 ◽  
Author(s):  
Gregory T. MacLennan ◽  
Liang Cheng
Keyword(s):  
Tubulocystic Carcinoma

A New Type of Renal Cancer—Tubulocystic Carcinoma of the Kidney

2013 ◽  
Vol 22 (4) ◽  
pp. 297-302 ◽  
Author(s):  
Jasneet Singh Bhullar ◽  
Neha Varshney ◽  
Amanpreet Kaur Bhullar ◽  
Vijay K. Mittal
Keyword(s):  
Renal Cancer ◽  
New Type ◽  
Tubulocystic Carcinoma

Tubulocystic Carcinoma of the Kidney with Fatal Outcome in an Adolescent Male

2014 ◽  
Vol 94 (4) ◽  
pp. 485-487
Author(s):  
Marco Gizzi ◽  
Selda Aydin ◽  
Jean-Pascal Machiels
Keyword(s):  
Molecular Genetic ◽  
Fatal Outcome ◽  
Renal Tumors ◽  
Adolescent Male ◽  
Vascular Endothelial ◽  
Cell Renal Cell Carcinoma ◽  
Factor Inhibitor ◽  
Endothelial Growth Factor ◽  
Unusual Metastases ◽  
Tubulocystic Carcinoma

Non-clear cell renal cell carcinoma accounts for about 20% of all kidney cancers. Tubulocystic carcinoma of the kidney (TCK) is a newly described entity with distinct molecular, genetic and clinical features. In 2013, it was one of five new renal tumors to be recognized by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. We describe here a case of TCK with a rare genetic signature, unusual metastases and limited response to an anti-vascular endothelial growth factor inhibitor in what we believe is the youngest patient on record to date.

scholarly journals Sunitinib in the treatment of tubulocystic carcinoma of the kidney. A case report

2008 ◽  
Vol 19 (9) ◽  
pp. 1655-1656 ◽  
Author(s):  
M. Mego ◽  
Z. Sycova-Mila ◽  
B. Rychly ◽  
J. Obertova ◽  
J. Rajec ◽  
...  
Keyword(s):  
Case Report ◽  
Tubulocystic Carcinoma

A case of tubulocystic carcinoma of the kidney with aggressive features

2016 ◽  
Vol 34 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Yoko Maeda ◽  
Keisuke Goto ◽  
Yukiko Honda ◽  
Naoto Kuroda ◽  
Kazuhiro Sentani ◽  
...  
Keyword(s):  
Tubulocystic Carcinoma
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