scholarly journals A Case of Post-Traumatic Retrograde and Anterograde Loss of Autobiographical Memory in the Absence of Medial Temporal Lobe Lesion

Cureus ◽  
2020 ◽  
Author(s):  
Ravindi Gunasekara ◽  
Shahzad Chida ◽  
Minahil Shahid ◽  
Gulshan Begum ◽  
Ayodeji Jolayemi
Keyword(s):  
Autobiographical Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Post Traumatic ◽  
Temporal Lobe Lesion

scholarly journals H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging

1997 ◽  
Vol 17 (10) ◽  
pp. 3964-3979 ◽  
Author(s):  
Suzanne Corkin ◽  
David G. Amaral ◽  
R. Gilberto González ◽  
Keith A. Johnson ◽  
Bradley T. Hyman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Resonance Imaging ◽  
Temporal Lobe Lesion

scholarly journals Autobiographical Memory and Patterns of Brain Atrophy in Fronto-temporal Lobar Degeneration

2008 ◽  
Vol 20 (10) ◽  
pp. 1839-1853 ◽  
Author(s):  
Margaret C. McKinnon ◽  
Elena I. Nica ◽  
Pheth Sengdy ◽  
Natasa Kovacevic ◽  
Morris Moscovitch ◽  
...  
Keyword(s):  
Autobiographical Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Functional Neuroimaging ◽  
Memory Loss ◽  
Behavioral Pattern ◽  
Remote Memory ◽  
Semantic Retrieval ◽  
Cross Sectional ◽  
Matched Comparison

Autobiographical memory paradigms have been increasingly used to study the behavioral and neuroanatomical correlates of human remote memory. Although there are numerous functional neuroimaging studies on this topic, relatively few studies of patient samples exist, with heterogeneity of results owing to methodological variability. In this study, fronto-temporal lobar degeneration (FTLD), a form of dementia affecting regions crucial to autobiographical memory, was used as a model of autobiographical memory loss. We emphasized the separation of episodic (recollection of specific event, perceptual, and mental state information) from semantic (factual information unspecific in time and place) autobiographical memory, derived from a reliable method for scoring transcribed autobiographical protocols, the Autobiographical Interview [Levine, B., Svoboda, E., Hay, J., Winocur, G., & Moscovitch, M. Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychology and Aging, 17, 677–689, 2002]. Patients with the fronto-temporal dementia (FTD) and mixed fronto-temporal and semantic dementia (FTD/SD) variants of FTLD were impaired at reconstructing episodically rich autobiographical memories across the lifespan, with FTD/SD patients generating an excess of generic semantic autobiographical information. Patients with progressive nonfluent aphasia were mildly impaired for episodic autobiographical memory, but this impairment was eliminated with the provision of structured cueing, likely reflecting relatively intact medial-temporal lobe function, whereas the same cueing failed to bolster the FTD and FTD/SD patients' performance relative to that of matched comparison subjects. The pattern of episodic, but not semantic, autobiographical impairment was enhanced with disease progression on 1- to 2-year follow-up testing in a subset of patients, supplementing the cross-sectional evidence for specificity of episodic autobiographical impairment with longitudinal data. This behavioral pattern covaried with volume loss in a distributed left-lateralized posterior network centered on the temporal lobe, consistent with evidence from other patient and functional neuroimaging studies of autobiographical memory. Frontal lobe volumes, however, did not significantly contribute to this network, suggesting that frontal contributions to autobiographical episodic memory may be more complex than previously appreciated.

Retrieval of autobiographical memory in Alzheimer's disease: Relation to volumes of medial temporal lobe and other structures

Hippocampus ◽  
2005 ◽  
Vol 15 (4) ◽  
pp. 535-550 ◽  
Author(s):  
Asaf Gilboa ◽  
Joel Ramirez ◽  
Stefan Köhler ◽  
Robyn Westmacott ◽  
Sandra E. Black ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

scholarly journals Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time

2007 ◽  
Vol 2007 ◽  
pp. 1-14 ◽  
Author(s):  
Lynn Nadel ◽  
Jenna Campbell ◽  
Lee Ryan
Keyword(s):  
Autobiographical Memory ◽  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Perirhinal Cortex ◽  
Brain Regions ◽  
Long Term Memory ◽  
Memory Traces ◽  
Multiple Trace Theory

Multiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI scanning, participants retrieved remote autobiographical memories that had been previously retrieved either one month earlier, two days earlier, or multiple times during the preceding month. Behavioral analyses revealed that the number and consistency of memory details retrieved increased with multiple retrievals but not with the passage of time. While all three retrieval conditions activated a similar set of brain regions normally associated with autobiographical memory retrieval including medial temporal lobe structures, hippocampal activation did not change as a function of either multiple retrievals or the passage of time. However, activation in other brain regions, including the precuneus, lateral prefrontal cortex, parietal cortex, lateral temporal lobe, and perirhinal cortex increased after multiple retrievals, but was not influenced by the passage of time. These results have important implications for existing theories of long-term memory consolidation.

scholarly journals Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe

2008 ◽  
Vol 105 (7) ◽  
pp. 2676-2680 ◽  
Author(s):  
C. B. Kirwan ◽  
P. J. Bayley ◽  
V. V. Galvan ◽  
L. R. Squire
Keyword(s):  
Autobiographical Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

Freiburg Neuropathology Case Conference: a Medial Temporal Lobe Lesion

2010 ◽  
Vol 20 (3) ◽  
pp. 179-182
Author(s):  
C. A. Taschner ◽  
O. Staszewski ◽  
V. van Velthoven ◽  
B. J. Steinhoff ◽  
I. Mader ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Case Conference ◽  
Temporal Lobe Lesion

Domain-specific impairment of source memory following a right posterior medial temporal lobe lesion

Hippocampus ◽  
2007 ◽  
Vol 17 (7) ◽  
pp. 505-509 ◽  
Author(s):  
Jan Peters ◽  
Benno Koch ◽  
Michael Schwarz ◽  
Irene Daum
Keyword(s):  
Temporal Lobe ◽  
Source Memory ◽  
Medial Temporal Lobe ◽  
Domain Specific ◽  
Temporal Lobe Lesion

scholarly journals Patterns of Autobiographical Memory Loss in Medial-Temporal Lobe Amnesic Patients

2008 ◽  
Vol 20 (8) ◽  
pp. 1490-1506 ◽  
Author(s):  
R. Shayna Rosenbaum ◽  
Morris Moscovitch ◽  
Jonathan K. Foster ◽  
David M. Schnyer ◽  
Fuqiang Gao ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Autobiographical Memory ◽  
Semantic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Loss ◽  
Hippocampal Damage ◽  
Severe Loss ◽  
Precise Quantification

The issue of whether the hippocampus and related structures in the medial-temporal lobe (MTL) play a temporary or permanent role in autobiographical episodic memory remains unresolved. One long-standing belief is that autobiographical memory (AM), like semantic memory, is initially dependent on the MTL but ultimately can be retained and recovered independently of it. However, evidence that hippocampal amnesia results in severe loss of episodic memory for a lifetime of personally experienced events suggests otherwise. To test the opposing views, we conducted detailed investigations of autobiographical episodic memory in people with amnesia resulting from MTL lesions of varying extent. By combining precise quantification of MTL and neocortical volumes with sensitive measures of recollection of one's personal past, we show that the severity of episodic, but not semantic, AM loss is best accounted for by the degree of hippocampal damage and less likely related to additional neocortical compromise.

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