scholarly journals Non-Bismuth Quadruple Therapy, Sequential Therapy or High-Dose Esomeprazole and Amoxicillin Dual Therapy for First-Line Helicobacter pylori Eradication: A Prospective Randomized Study

Cureus ◽  
2020 ◽  
Author(s):  
Zeriouh Meriem ◽  
Amine Elmekkaoui ◽  
Mouna Bouqfar ◽  
Abdelkrim Zazour ◽  
Wafaa Khannoussi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Randomized Study ◽  
Sequential Therapy ◽  
Dual Therapy ◽  
Prospective Randomized Study ◽  
High Dose ◽  
First Line ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy

A Prospective, Randomized Study of Quadruple Therapy and High-Dose Dual Therapy for Treatment of Helicobacter Pylori Resistant to Both Metronidazole and Clarithromycin

Helicobacter ◽  
2003 ◽  
Vol 8 (4) ◽  
pp. 310-319 ◽  
Author(s):  
Stephan Miehlke ◽  
Christian Kirsch ◽  
Wulf Schneider-Brachert ◽  
Christian Haferland ◽  
Michael Neumeyer ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Randomized Study ◽  
Dual Therapy ◽  
Prospective Randomized Study ◽  
High Dose ◽  
Quadruple Therapy

scholarly journals High dose dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication treatment

Medicine ◽  
2019 ◽  
Vol 98 (7) ◽  
pp. e14396 ◽  
Author(s):  
Xue Yang ◽  
Jin-Xia Wang ◽  
Sheng-Xi Han ◽  
Cai-Ping Gao
Keyword(s):  
Helicobacter Pylori ◽  
Dual Therapy ◽  
High Dose ◽  
Helicobacter Pylori Eradication ◽  
Quadruple Therapy

Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a prospective randomized study

2013 ◽  
Vol 69 (9) ◽  
pp. 1709-1715 ◽  
Author(s):  
Hassan Seddik ◽  
Samir Ahid ◽  
Tarek El Adioui ◽  
Fatim-Zohra El Hamdi ◽  
Mohammed Hassar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Drug Therapy ◽  
Randomized Study ◽  
Sequential Therapy ◽  
Prospective Randomized Study ◽  
Helicobacter Pylori Eradication

scholarly journals High dose PPI-amoxicillin dual therapy for the treatment of Helicobacter pylori infection: a systematic review with meta-analysis

2020 ◽  
Vol 13 ◽  
pp. 175628482093711
Author(s):  
Yang-Jie Zhu ◽  
Yi Zhang ◽  
Ting-Yi Wang ◽  
Jing-Tao Zhao ◽  
Zhe Zhao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Adverse Events ◽  
Eradication Rate ◽  
Meta Analysis ◽  
Dual Therapy ◽  
Controlled Trials ◽  
High Dose ◽  
First Line ◽  
Quadruple Therapy ◽  
H Pylori

Background: Helicobacter pylori resistance to amoxicillin remains rare in many regions. Proton pump inhibitor-amoxicillin-containing high dose dual therapy (HDDT) has been proposed to treat H. pylori infection. We aimed to assess the effectiveness and safety of PPI-amoxicillin HDDT for treatment of H. pylori infection in comparison with other regimens. Methods: Databases, including PubMed, Embase, and the Cochrane Register of Controlled Trials, were searched to find relevant publications. Randomized controlled trials comparing HDDT with control regimens for H. pylori eradication in adult patients were included. The primary outcome was eradication rate by intention-to-treat analysis. Adverse events were analyzed as second outcome. Results: A total of 15 trials with 3818 patients qualified for inclusion. The eradication rate of HDDT was neither significantly inferior nor superior to the recommended regimens such as triple therapy, bismuth quadruple therapy, and non-bismuth quadruple therapy [relative risk (RR): 1.00, 95% confidence interval (CI): 0.96–1.05, p = 0.870]. This finding was robust through subgroup analyses and sensitivity analyses. Trial sequential analysis showed that HDDT was equivalent to control regimens, and further similar trials were unlikely to alter the conclusions of this analysis. The frequency of adverse events was significantly lower in HDDT group (RR: 0.48, 95% CI: 0.37–0.64, p < 0.001). Conclusion: HDDT was equivalent to recommended first-line or rescue regimens with fewer adverse effects. The evidence from this meta-analysis supports the use of HDDT as first-line or rescue treatment for H. pylori infection. Trial registration: PROSPERO CRD42019133002

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