scholarly journals Metabolic, Hormonal, Immunologic, and Genetic Factors Associated With the Incidence of Thyroid Disorders in Polycystic Ovarian Syndrome Patients

Cureus ◽  
2020 ◽  
Author(s):  
Jaya Singh ◽  
Hilda Wong ◽  
Nancy Ahluwalia ◽  
Ryan M Go ◽  
Michelle A Guerrero-Go
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Genetic Factors ◽  
Thyroid Disorders ◽  
Factors Associated ◽  
Ovarian Syndrome

scholarly journals 2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction

2020 ◽  
Vol 9 (6) ◽  
pp. 281-295
Author(s):  
Kris Poppe ◽  
Peter Bisschop ◽  
Laura Fugazzola ◽  
Gesthimani Minziori ◽  
David Unuane ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Embryo Quality ◽  
Thyroid Autoimmunity ◽  
Thyroid Disorders ◽  
Menstrual Disorders ◽  
Normal Thyroid Function ◽  
Increased Risk ◽  
Meta Analyses ◽  
Ovarian Syndrome ◽  
Serum Tsh

Severe thyroid dysfunction may lead to menstrual disorders and subfertility. Fertility problems may persist even after restoring normal thyroid function, and then an assisted reproductive technology (ART) may be a solution. Prior to an ART treatment, ovarian stimulation is performed, leading to high oestradiol levels, which may lead to hypothyroidism in women with thyroid autoimmunity (TAI), necessitating levothyroxine (LT4) supplements before pregnancy. Moreover, women with the polycystic ovarian syndrome and idiopathic subfertility have a higher prevalence of TAI. Women with hypothyroidism treated with LT4 prior to ART should have a serum TSH level <2.5 mIU/L. Subfertile women with hyperthyroidism planning an ART procedure should be informed of the increased risk of maternal and foetal complications, and euthyroidism should be restored and maintained for several months prior to an ART treatment. Fertilisation rates and embryo quality may be impaired in women with TSH >4.0 mIU/L and improved with LT4 therapy. In meta-analyses that mainly included women with TSH levels >4.0 mIU/L, LT4 treatment increased live birth rates, but that was not the case in 2 recent interventional studies in euthyroid women with TAI. The importance of the increased use of intracytoplasmic sperm injection as a type of ART on pregnancy outcomes in women with TAI deserves more investigation. For all of the above reasons, women of subfertile couples should be screened routinely for the presence of thyroid disorders.

scholarly journals Genetics Poly Cystic Ovary Syndrome

2016 ◽  
Vol 1 (4) ◽  
pp. 97-105
Author(s):  
Atekeh Bahadori ◽  
Afrouz Khazamipour ◽  
Dariush D.Farhud
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Genetic Factors ◽  
Life Quality ◽  
Insulin Level ◽  
Breast Cancers ◽  
Diabetes Type Ii ◽  
Hereditary Factors ◽  
Neurological Effects ◽  
Criteria For Diagnosis ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome is a complicated hereditary disorder which does not have specific reason and 6-10% of women at fertility age are involved. In other word we can say that this syndrome is a familial hereditary syndrome which developed with combination of environmental and genetic factors. Polycystic ovarian syndrome (PCOS) is related to cardiovascular diseases and has psychological and neurological effects on life quality as well as uterine and breast cancers. The main criteria for diagnosis of polycystic ovarian syndrome are chronic anovulation and hyperandogenism and the sub-criteria are insulin resistance, hirsutism and obesity onset at menarche age, anovulation alternatively is associated with increased testosterone level and DHEA-S. The cause of polycystic ovarian syndrome (PCO) is unknown, but it could be the result of complex genetic factors which are evident at puberty onset, also hereditary and non-hereditary factors could be the cause of polycystic ovarian syndrome (PCO) pheno ype. In many women with polycystic ovarian syndrome, the insulin level is high. It seems that high levels of insulin increase androgens production. High levels of androgens can cause acne, supernumerary hair growth, weight gain, and ovulation problem.Conclusion: Early diagnosis and treatment of polycystic ovarian syndrome could help to reduce long-term complications such as diabetes type II, high blood pressure, heart disease and stroke.

scholarly journals Evaluation of Thyroid Hormones and AntiThyroglobulin Antibodies among Sudanese Polycystic Ovarian Syndrome Patients

2020 ◽  
Vol 27 (3) ◽  
pp. 191-194
Author(s):  
Rofida Abuobaida KAMIL ◽  
Nuha Eljailli ABUBAKER ◽  
Seifeldeen Ahmed MOHAMED ◽  
Mariam Abbas IBRAHIM ◽  
Ahmed Bakheet ABD ALLA
Keyword(s):  
Thyroid Hormones ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Controlled Study ◽  
Control Group ◽  
Endocrine Disorders ◽  
Thyroid Disorders ◽  
Thyroid Autoantibody ◽  
Thyroglobulin Antibodies ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) and thyroid disorders are the most common endocrine disorders in women. Evidently, the involvement of polycystic ovarian syndrome (PCOS) and thyroid autoimmunity triggering thyroid disorders has not yet occurred. Objective: The aim was to assess serum free tri-iodothyronine (FT3), free thyroxin (FT4) and anti-thyroglobulin antibodies among polycystic ovary syndrome Sudanese patients. Materials and methods: Fifty Sudanese patients diagnosed with PCOS and 50 healthy age matched females were recruited in this cross-sectional controlled study. Serum FT3 and FT4 were measured by an immunoassay analyzer and serum anti-thyroglobulin antibodies were measured using ELISA. The data was then analyzed using the SPSS. Results: The results showed a signifi cant increase in serum FT3 and anti-thyroglobulin antibodies and there was no statistical difference in PCOS serum FT4 levels compared to the control group. The results revealed no correlation between levels of FT3, FT4 and anti-thyroglobulin antibodies with age; also there were no correlation between levels of FT3 and FT4 with BMI while there was a positive correlation between anti-thyroglobulin antibodies levels and BMI. Conclusion: Patients with PCOS had elevated FT3 and antithyroglobulin. Therefore, the assessment of thyroid autoantibody with thyroid hormones in patients with PCOS should be investigated.

Factors associated with risk for depression among women with polycystic ovarian syndrome

2008 ◽  
Vol 90 ◽  
pp. S178 ◽  
Author(s):  
L.A. Pasch ◽  
J. Lamb ◽  
W. Shelly ◽  
J. Sandler ◽  
Z. Lee ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Factors Associated ◽  
Ovarian Syndrome ◽  
Risk For Depression

THYROID DISORDERS AND POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Neeti Mahla ◽  
Mukesh Choudhary
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Endocrine Disorders ◽  
Thyroid Disorders ◽  
Ovary Syndrome ◽  
High Prevalence ◽  
Pcos Group ◽  
Thyroid Profile ◽  
Ovarian Syndrome

Background: Thyroid disorders and polycystic ovary syndrome (PCOS) are two of the most common endocrine disorders in the general population. To study the thyroid profile in polycystic ovarian syndrome. Methods: 50 cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Results: In our study T4 level was significantly lower in PCOS group (0.69± 0.56 ng/ml ) as compare to control  (1.87± 0.86 ng/ml ). T3 level was significantly higher in PCOS group (2.38± 1.09 ng/ml) as compare to control  (2.11± 1.06 ng/ml ). TSH level was significantly higher in PCOS group (8.12± 6.32 ng/ml ) as compare to control  (3.36± 1.06 ng/ml ). Conclusion: High prevalence of thyroid disorders in PCOS patients thus points towards the importance of early correction of hypothyroidism in the management of infertility associated with PCOS. Keywords: T4, T3, TSH, PCOS

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