scholarly journals Marginal Cell Lymphoma Presenting as a Primary Submandibular Tumor

Cureus ◽  
2020 ◽  
Author(s):  
Ani Mnatsakanian ◽  
Suzanne Forman ◽  
Shant A Korkigian
Keyword(s):  
Cell Lymphoma ◽  
Marginal Cell

Detection of Clonality in Lymphoproliferations Using PCR of the Antigen Receptor Genes: Does Size Matter?.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4622-4622
Author(s):  
Paul G. Rothberg ◽  
Roberto L. Vargas ◽  
Raymond E. Felgar ◽  
Susan L. Polochock ◽  
Sharon D. Frazier
Keyword(s):  
Cell Lymphoma ◽  
Antigen Receptor ◽  
B Cell Lymphoma ◽  
Pcr Primers ◽  
Convincing Evidence ◽  
Low Grade ◽  
Marginal Cell ◽  
Igh Rearrangement ◽  
Size Limits ◽  
Size Matter

Abstract A biopsy of a nasal mass was received from another institution for a hematopathology consultation. The specimen had morphologic and immunostaining features consistent with a B-cell lymphoma, histologically low-grade, and suggestive for an extranodal marginal cell lymphoma of mucosa associated lymphoid tissue (MALT) type. We used PCR of the IgH gene to evaluate clonality on DNA derived from this specimen. The primers were from the BIOMED-2 report (van Dongen et al. 2003, Leukemia17:2257) and the amplicons were subjected to heteroduplex formation prior to PAGE. A homoduplex of approximately 140 bp was obtained reproducibly from the FR2 and JH primers, which is below the usually acceptable size limits of 250–295 bps. No homoduplex was obtained using FR3 and JH primers. We sequenced the FR2/JH amplicon using the PCR primers as sequencing primers. The amplicon was 137 bps, with 92 bps between the primers. After the upstream VH3 FR2 primer there were approximately 25 bps from the FR2 region of several members of the VH3 family, with VH3-49 (allele *03) being the best match. Adjacent to the downstream consensus JH primer there were approximately 30 bp from the J6 segment. Between the identifiable sequences there were 37 bp that we could not identify. Blast searches turned up several matches of 18 bp, but nothing that gave convincing evidence for its origin. We interpret these results as indicating a clonal IgH rearrangement followed by a deletion that removed most of the downstream portion of the V segment, including the FR3 region. It is likely that the 37 bp in between the identified IgH segments consists of randomly inserted nucleotides and IgH sequence that has been somatically mutated beyond recognition, although other interpretations are possible. However, the amplicon does appear to be derived from an IgH rearrangement, which is consistent with derivation from a monoclonal population of B-lymphocytes. This work illustrates that DNA fragments outside of the size range expected from PCR of the antigen receptor genes may still be consistent with a monoclonal result. Thus, this type of result should not be dismissed, but should be subjected to further analysis.

scholarly journals Clinical and Histopathological Findings in Patients Who Underwent Splenectomy: A Ten-Year Study in Iran

2020 ◽  
Author(s):  
Arash Dehghan ◽  
Nika Eskandari ◽  
Nakisa Niknejad
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cross Sectional Study ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Thrombocytopenic Purpura ◽  
Marginal Cell ◽  
Histopathological Findings ◽  
Large B Cell Lymphoma

The description of histopathological features of spleen specimens in those are undergoing splenectomy is necessary and even vital for selecting the best patient's diagnostic and therapeutic management. However, in some cases, the histological findings of those with dramatic clinical presentation may be imperceptible and vice versa. What we did in the present study was to assess the clinical and histopathological findings as well as the main indications for splenectomy in a sample of Iranian affected population. This cross-sectional study was conducted on 616 spleen specimens following complete or partial splenectomy performed at pathology laboratory at Besat Hospital in Hamadan, Iran, between 2007 and 2017. Demographic characteristics, the main reasons for splenectomy, grading of trauma, and histopathological findings were retrospectively collected by reviewing the hospital recorded files and laboratory reports. The most common cause for splenectomy included trauma in 59.25%, followed by idiopathic thrombocytopenic purpura in 15.58% and symptomatic splenomegaly in 9.09%. The specimens were normal at 38.0%. Among those with lymphoma, the definitive diagnosis included diffused large B cell lymphoma in 42.85%, Hodgkin lymphoma in 42.85%, Follicular cell lymphoma in 9.52%, and Marginal cell lymphoma in 4.76%. Trauma and idiopathic thrombocytopenic purpura are the most common indications for splenectomy. Given the normality of the pathologic findings in more than one-third of patients undergoing splenectomy, closer attention to indications for this procedure through further evaluation of patients and predicting the outcome of the procedure is necessary.

Orbital marginal cell lymphoma and mantle cell lymphoma subclone in patient with monoclonal gammopathy of unknown significance

Orbit ◽  
2020 ◽  
pp. 1-5
Author(s):  
Sitara H. Hirji ◽  
Michelle M. Maeng ◽  
Andrea A. Tooley ◽  
Craig Soderquist ◽  
Joseph Annunziata ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Monoclonal Gammopathy ◽  
Cell Lymphoma ◽  
Marginal Cell ◽  
Mantle Cell ◽  
Unknown Significance

scholarly journals Bortezomib Induced Hepatitis B Reactivation

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Salwa Hussain ◽  
Ruby Jhaj ◽  
Samira Ahsan ◽  
Muhammad Ahsan ◽  
Robert E. Bloom ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Liposomal Doxorubicin ◽  
Viral Infections ◽  
Cell Lymphoma ◽  
Hepatitis B Surface Antigen ◽  
Hbv Reactivation ◽  
Marginal Cell ◽  
Unique Event ◽  
Therapy Initiation ◽  
History Of

Background. It has recently been reported that hepatitis B (HBV) reactivation often occurs after the use of rituximab and stem cell transplantation in patients with lymphoma who are hepatitis B surface antigen (HBsAg) negative. However, clinical data on HBV reactivation in multiple myeloma (MM) is limited to only a few reported cases. Bortezomib and lenalidomide have remarkable activity in MM with manageable toxicity profiles, but reactivation of viral infections may emerge as a problem. We present a case of MM that developed HBV reactivation after bortezomib and lenalidomide therapy.Case Report. A 73-year-old female with a history of marginal cell lymphoma was monitored without requiring therapy. In 2009, she developed MM, presenting as a plasmacytoma requiring vertebral decompression and focal radiation. While receiving radiation she developed renal failure and was started on bortezomib and liposomal doxorubicin. After a transient response to 5 cycles, treatment was switched to lenalidomide. Preceding therapy initiation, her serology indicated resolved infection. Serial monitoring for HBV displayed seroconversion one month after change in therapy.Conclusion. Bortezomib associated late HBV reactivation appears to be a unique event that requires further confirmation and brings to discussion whether hepatitis B core positive individuals would benefit from monitoring of HBV activation while on therapy.

Diagnosis of Marginal Cell Lymphoma of Small Intestine by Double Balloon Enteroscopy

2008 ◽  
Vol 101 (5) ◽  
pp. 561-564 ◽  
Author(s):  
Kamini Giri ◽  
Cynthia Sudar ◽  
Mukul Arya ◽  
Gregory Haber ◽  
Pradeep Chandra
Keyword(s):  
Small Intestine ◽  
Cell Lymphoma ◽  
Double Balloon Enteroscopy ◽  
Marginal Cell ◽  
Balloon Enteroscopy ◽  
Double Balloon

scholarly journals Primary Pulmonary Marginal Cell Lymphoma: Your Eyes See Only What Your Mind Knows

2021 ◽  
Vol 22 (3) ◽  
pp. 271-273
Author(s):  
Aqeel Hussain ◽  
◽  
Rajkrishnan Soman ◽  
Abhishek Goyal ◽  
Ujjawal Khurana ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
Marginal Cell

scholarly journals PRIMARY SJOGREN SYNDROME CAUSING PULMONARY EXTRANODAL MARGINAL CELL LYMPHOMA

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1636
Author(s):  
Muhammad Danial Siddiqui ◽  
Touba Naim ◽  
Muhammad Hamza ◽  
Travis Hanson
Keyword(s):  
Cell Lymphoma ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Marginal Cell ◽  
Primary Sjögren Syndrome

Primary Extranodal Marginal Cell Lymphoma, MALT Type, of the Endometrium Arising in a Patient With Rheumatoid Arthritis

2016 ◽  
Vol 35 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Francesca Magnoli ◽  
Laura Cimetti ◽  
Barbara Bernasconi ◽  
Nora Sahnane ◽  
Isabella Redaelli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Lymphoma ◽  
Marginal Cell
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