scholarly journals Applications of Silk in Drug Delivery: Advancement in Pharmaceutical Dosage Forms

Cureus ◽  
2013 ◽  
Author(s):  
Anubhav Nagal ◽  
Rajeev K Singla
Keyword(s):  
Drug Delivery ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms

An Overview of Excipients Classification and Their Use in Pharmaceuticals

2020 ◽  
Vol 16 ◽  
Author(s):  
Cansel Kose Ozkan ◽  
Ozgur Esim ◽  
Ayhan Savaser ◽  
Yalcin Ozkan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Dosage Forms ◽  
Design Development ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Product Identification ◽  
Direct Administration ◽  
Active Substances

: The content and the application of pharmaceutical dosage forms must meet several basic requirements to ensure and maintain efficiency, safety and quality. A large number of active substances have limited ability to direct administration. Excipients are generally used to overcome the limitation of direct administration of these active substances. However, the function, behavior and composition of the excipients need to be well known in the design, development and production of pharmaceutical dosage forms. In this review, excipients used to assist in any pharmaceutical dosage form production processes of drugs, to preserve, promote or increase stability, bioavailability and patient compliance, to assist in product identification / separation, or to enhance overall safety and effectiveness of the drug delivery system during storage or use are explained. Moreover, the use of these excipients in drug delivery systems are identified. Excipient toxicity, which is an issue discussed in the light of current studies, also discussed in this review.

scholarly journals Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects

2010 ◽  
Vol 11 (9) ◽  
pp. 3298-3322 ◽  
Author(s):  
Heidi M. Mansour ◽  
MinJi Sohn ◽  
Abeer Al-Ghananeem ◽  
Patrick P. DeLuca
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Release Drug

Colonic Bacterial Enzymes

2018 ◽  
pp. 71-99 ◽  
Author(s):  
Srushti M. Tambe ◽  
Namita D. Desai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Specific Drug ◽  
Bacterial Enzymes ◽  
In Vitro Drug Release ◽  
Pharmaceutical Dosage Forms ◽  
Colon Specific Drug Delivery

This chapter reviews various enzymes produced by the colonic microflora and their utilization in the development of pharmaceutical dosage forms to achieve colon-specific drug delivery. This chapter discusses the applications of colonic bacterial enzymes in order to surrogate colonic conditions in vivo so as to evaluate in vitro drug release from microbially triggered/enzymatically triggered colon-specific drug delivery systems. This chapter also discusses different methods to produce colonic bacterial enzymes as well as use of probiotics as a source to produce colonic bacterial enzymes.

scholarly journals Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 217 ◽  
Author(s):  
Gerardo Leyva-Gómez ◽  
María L. Del Prado-Audelo ◽  
Silvestre Ortega-Peña ◽  
Néstor Mendoza-Muñoz ◽  
Zaida Urbán-Morlán ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Contact Surface ◽  
Dosage Forms ◽  
Vaginal Microbiota ◽  
Attractive Alternative ◽  
Systemic Effects ◽  
Pharmaceutical Dosage Forms ◽  
Vaginal Drug Delivery ◽  
Challenges And Opportunities

Vaginal drug delivery represents an attractive alternative to achieve local and systemic effects due to the high contact surface exposed, the mucoadhesion of the epithelium, and the high innervation that facilitates the absorption of drugs into the bloodstream. However, despite the confinement of the vaginal cavity, it is an organ with a highly variable microenvironment. Mechanical alterations such as coitus, or chemical changes such as pH and viscosity, modify the release of drugs. In addition, changes in vaginal microbiota can influence the entire vaginal microenvironment, thus determining the disposition of drugs in the vaginal cavity and decreasing their therapeutic efficacy. Therefore, the influence of microorganisms on vaginal homeostasis can change the pre-established scenario for the application of drugs. This review aims to provide an explanation of normal vaginal microbiota, the factors that modify it, its involvement in the administration of drugs, and new proposals for the design of novel pharmaceutical dosage forms. Finally, challenges and opportunities directed toward the conception of new effective formulations are discussed.

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