scholarly journals Severe Sepsis With Septic Shock as a Consequence of a Severe Community-Acquired Pneumonia Resulting From a Combined Legionella pneumophila and Streptococcus pneumoniae Infection

Cureus ◽  
2020 ◽  
Author(s):  
Jose Orsini ◽  
Brendan J Frawley ◽  
Hannah Gawlak ◽  
Rebecca Gooch ◽  
Javier Escovar
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Streptococcus Pneumoniae ◽  
Legionella Pneumophila ◽  
Community Acquired Pneumonia ◽  
Severe Community Acquired Pneumonia

scholarly journals Bronchoalveolar lavage findings in severe community-acquired pneumonia due to Legionella pneumophila serogroup 1

2004 ◽  
Vol 98 (12) ◽  
pp. 1222-1226 ◽  
Author(s):  
Rocco Trisolini ◽  
Luigi Lazzari Agli ◽  
Alessandra Cancellieri ◽  
Leonarda Procaccio ◽  
Piero Candoli ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Legionella Pneumophila ◽  
Community Acquired Pneumonia ◽  
Severe Community Acquired Pneumonia

Community-acquired pneumonia and acute kidney injury

2018 ◽  
Author(s):  
Norbert Lameire
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Organ Dysfunction ◽  
Kidney Injury ◽  
Community Acquired Pneumonia

It is known that in one-half of the patients hospitalized for community-acquired pneumonia, severe sepsis develops, with non-pulmonary organ dysfunction developing in more than one-third and septic shock in 4.5%. Some years ago, it was found that acute kidney injury was common in community-acquired pneumonia even in patients who appeared to have an uncomplicated course of community-acquired pneumonia and where acute kidney injury was observed in one-quarter of them.

Severe Sepsis With Septic Shock as a Consequence of a Severe Hospital-Acquired Pneumonia Resulting From Legionella Pneumophila in Children: A Case Series and Literature Review

2020 ◽  
Author(s):  
Min Ding ◽  
Chunfeng Yang ◽  
Yu-mei Li
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Next Generation Sequencing ◽  
Antibiotic Therapy ◽  
Legionella Pneumophila ◽  
High Risk Population ◽  
Next Generation ◽  
Hospital Acquired Pneumonia ◽  
Hospital Acquired ◽  
Generation Sequencing

Abstract BackgroundLegionella pneumophila is responsible for hospital or community-acquired pneumonia in adults. Immunocompromised patients with Legionella pneumophila infection are associated with rapidly severe clinical course and high mortality rates. Legionella pneumophila infection is rare in children, especially combined with extrapulmonary manifestations. In this report, we describe 2 children of severe hospital-acquired pneumonia and septic shock resulting from Legionella pneumophila. Standardized metagenomics next-generation sequencing allowed early diagnosis. Appropriate antibiotic therapy and timely extracorporeal life support were effective in achieving complete recovery. This is the first report of children with septic shock related to Legionella pneumophila infections diagnosed by metagenomics next-generation sequencing and recovered successfully.Case presentationThere were 2 cases about septic shock resulting from Legionella pneumophila. One was a six-month girl with congenital biliary atresia who underwent liver transplantation. She was suspected for rejecting the liver and admitted to hospital. The other one was a five-year-old boy with Burkitt lymphoma who was in the end of early chemotherapy. They both presented with fever, cough or shortness of breath during hospitalization. And they were transferred to PICU because of worsening dyspnea and decreased blood pressure. Patients were diagnosed by severe sepsis with septic shock likely resulting from hospital-acquired pneumonia. Metagenomics next-generation sequencing indicated L. pneumophila in blood and sputum. Aggressive intravenous fluids resuscitation and vasopressors were initiated on arrival to PICU, and they were placed on mechanical ventilation and continuous renal replacement therapy. Intravenous antibiotic therapy followed by azithromycin. Finally, the patients recovered without any long-term sequelae.ConclusionsThough sepsis or sepsis shock caused by Legionella pneumophila is rare in children, it can occur at high-risk population. Metagenomics next-generation sequencing is useful for conforming hard-to-culture pathogens and severely ill patients. The report remind pediatric physicians that we should be aware that Legionella pneumophila can cause severe sepsis or sepsis shock, especially in immunocompromised children. It is significant to select appropriate samples and pathogen detection methods in the early stage of disease.

scholarly journals Severe Community-Acquired Pneumonia due to Acinetobacter baumannii in North America: Case Report and Review of the Literature

2018 ◽  
Vol 5 (3) ◽  
Author(s):  
David P Serota ◽  
Mary Elizabeth Sexton ◽  
Colleen S Kraft ◽  
Federico Palacio
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Acute Respiratory Distress Syndrome ◽  
Case Report ◽  
North America ◽  
Acinetobacter Baumannii ◽  
Distress Syndrome ◽  
Community Acquired Pneumonia ◽  
Review Of The Literature ◽  
Severe Community Acquired Pneumonia

Abstract Acinetobacter baumannii is a rare but emerging cause of fulminant community-acquired pneumonia (CAP-AB). We describe a patient from a rural area who developed acute respiratory distress syndrome and septic shock. We describe risk factors and characteristics of this syndrome and review published cases of CAP-AB from North America.

scholarly journals Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance?

2021 ◽  
Author(s):  
Edward Portal ◽  
Ghislaine Descours ◽  
Christophe Ginevra ◽  
Massimo Mentasti ◽  
Baharak Afshar ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Legionella Pneumophila ◽  
Susceptibility Testing ◽  
Solid Medium ◽  
Community Acquired Pneumonia ◽  
High Morbidity ◽  
Testing Methods ◽  
Severe Community Acquired Pneumonia ◽  
Microbroth Dilution ◽  
Reference Strains

Abstract Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire’s disease, a form of severe community-acquired pneumonia. Infection can have high morbidity, with a high proportion of patients requiring ICU admission, and up to 10% mortality, which is exacerbated by the lack of efficacy of typical empirical antibiotic therapy against Legionella spp. The fastidious nature of the entire Legionellaceae family historically required inclusion of activated charcoal in the solid medium to remove growth inhibitors, which inherently interferes with accurate antimicrobial susceptibility determination, an acknowledged methodological shortfall, now rectified by a new solid medium that gives results comparable to those of microbroth dilution. Here, as an international Legionella community (with authors representing various international reference laboratories, countries and clinical stakeholders for diagnosis and treatment of legionellosis), we set out recommendations for the standardization of antimicrobial susceptibility testing methods, guidelines and reference strains to facilitate an improved era of antibiotic resistance determination.

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