Lack of Patient Knowledge Regarding the Adverse Effects of Analgesics With High Doses Leading to Elevation of Creatinine and Major Consequences – A Case Report

Objective: Dextropropoxyphene is a commonly used analgesic despite its high toxicity in overdose and potential for abuse and dependence. This case report highlights these dangers. Clinical picture: The case of a female who was addicted to dextropropoxyphene as an alternative to other opioids is described. Its use in high doses with other psychotropic agents resulted in adverse health effects. Treatment: The patient was treated with methadone and psychosocial interventions. Outcome: The patient reduced her drug use and experienced improved physical health and psychosocial functioning. Conclusions: Caution is needed when prescribing dextropropoxyphene because of its adverse effects compared with equally efficacious analgesics.

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High-dose fentanyl dependence: a case report

Ból ◽

10.5604/01.3001.0014.8074 ◽

2021 ◽

Vol 21 (4) ◽

pp. 48-53

Author(s):

Michał Kurek ◽

Izabela Kurek ◽

Tadeusz Nasierowski ◽

Małgorzata Malec-Milewska

Keyword(s):

Chronic Pain ◽

Case Report ◽

Adverse Effects ◽

High Dose ◽

High Doses

Usage of opioids in chronic pain may cause many adverse effects. One of them is a risk of addiction. We would like to present a case report of detoxification of a 76-years old patient. She was addicted to high doses of fentanyl (totally 14400 μg fentanyl per day – 400 μg/h in transdermal system and 12 transmucosal pills per day).

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Delayed-Type Hypersensitivity Reaction to Red Tattoo Ink Triggered by Ledipasvir/Sofosbuvir for Hepatitis C: A Case Report

Case Reports in Dermatology ◽

10.1159/000513926 ◽

2021 ◽

pp. 379-383

Author(s):

Meghan L. McPhie ◽

Kevin Y.M. Ren ◽

J. Michael Hendry ◽

Sonja Molin ◽

Thomas Herzinger

Keyword(s):

Case Report ◽

Hepatitis C ◽

Adverse Effects ◽

Hypersensitivity Reaction ◽

Allergic Reaction ◽

Delayed Type Hypersensitivity ◽

Histological Features

Tattoos have become increasingly popular worldwide making adverse effects from tattoos a growing concern. In our report, we present a 51-year-old man who developed an unusual allergic reaction to the red ink portions of his tattoos that coincided with the initiation of ledipasvir/sofosbuvir treatment for his hepatitis C. Clinical and histological features were consistent with a delayed-type hypersensitivity reaction to red ink.

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Plaque erosion causing ST-elevation myocardial infarction after consumption of cannabis and N2O in a 27-year old man: a case report

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-01953-3 ◽

2021 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Sarah Bär ◽

Fabien Praz ◽

Lorenz Räber

Keyword(s):

Myocardial Infarction ◽

Case Report ◽

Adverse Effects ◽

Cardiovascular Effects ◽

Drug Eluting Stent ◽

Culprit Lesion ◽

Vascular Events ◽

The Public ◽

Plaque Erosion ◽

First Case

Abstract Background The recreational drugs cannabis and nitrous oxide (N2O) are known for pro-atherogenic effects and are associated with an elevated risk of myocardial infarction. These cardiovascular effects might be underestimated by the public. Culprit-lesion composition of myocardial infarctions associated with cannabis and N2O has been unknown so far. This case report aims to raise the awareness of the adverse cardiovascular effects of cannabis and N2O and reports, for the first time, optical coherence tomography (OCT) findings of the culprit lesion. Case presentation This is a case report of a 27-year old man with anterior ST-segment-elevation myocardial infarction (STEMI) after intoxication with cannabis and N2O. Coronary angiography and OCT revealed plaque erosion with subsequent subtotal thrombotic occlusion of the left anterior descending artery that was successfully treated with 1 drug-eluting stent. The patient was symptom free at 6 months follow-up and had been able to abstain from drug consumption. Conclusions This is the first case to demonstrate the association between cannabis and N2O abuse and plaque erosion on OCT in a young man with STEMI. In contrast to smoking, whose adverse effects are well-known, the cardiovascular effects of cannabis and N2O might be underestimated. These adverse effects should gain more awareness in the public to prevent early vascular events in young adults.

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Special Considerations in the Use of Glucocorticoids in Children

Pediatrics in Review ◽

10.1542/pir.16.7.266 ◽

1995 ◽

Vol 16 (7) ◽

pp. 266-272

Author(s):

Joseph D. Spahn ◽

Alan K. Kamada

Keyword(s):

Adverse Effects ◽

Autoimmune Diseases ◽

Early Recognition ◽

Therapeutic Effects ◽

Therapeutic Modalities ◽

High Doses

GCs are used commonly for the treatment of various inflammatory and autoimmune diseases. Although potent and generally effective, they are not without risks for producing serious adverse effects, especially when used in high doses for prolonged periods of time. Thus, the clinician must balance the therapeutic effects of GCs with their risks for adverse effects; using the lowest possible effective GC doses as well as maximizing other therapeutic modalities are means by which this goal can be achieved. Early recognition and appropriate management are other methods to minimize GC-induced adverse effects. Maximization of therapy, early recognition, and appropriate management of adverse effects can minimize the potential severe complications of GC therapy.

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Psychiatric shades of grey: mirtazapine-induced hair discoloration and hair loss

Irish Journal of Psychological Medicine ◽

10.1017/ipm.2015.71 ◽

2016 ◽

Vol 33 (3) ◽

pp. 175-178 ◽

Cited By ~ 1

Author(s):

M. Osman ◽

M. D. McCauley

Keyword(s):

Major Depressive Disorder ◽

Case Report ◽

Adverse Effects ◽

Depressive Disorder ◽

Hair Loss ◽

Temporal Relationship ◽

Relevant Literature ◽

Major Depressive ◽

Hair Colour ◽

Medical Reason

IntroductionMirtazapine is indicated in the treatment of major depressive disorder particularly in selective serotonin re-uptake inhibitors resistance. Its effect on hair loss is rare with no previous documented effect on hair colour.MethodReview of relevant literature and description of a case report of a 54-year-old male patient who developed alopecia and hair discoloration after initiation of mirtazapine treatment.ResultsUpon cessation of mirtazapine treatment full restoration of hair colour and regrowth of hair was attained within 10 weeks.DiscussionThere was clear temporal relationship between experiencing hair loss and commencing mirtazapine treatment. No other more likely medical reason to explain such experience was established. A noticeable restoration of the hair colour occurred following mirtazapine cessation.ConclusionMirtazapine is associated with hair discoloration and hair loss. The possibility of such distressing adverse effects needs to be conveyed to patients by clinicians and to be further explored by researchers.

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O56 Adverse effects of cocaine — a case report

European Journal of Internal Medicine ◽

10.1016/s0953-6205(03)91205-2 ◽

2003 ◽

Vol 14 ◽

pp. S17

Author(s):

M. Monteiro ◽

V. Mendes ◽

P. Ferreira ◽

C. Tapadinha ◽

R. Cordeiro ◽

...

Keyword(s):

Case Report ◽

Adverse Effects

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Monthly low-dose immunoglobulin infusion as a maintenance therapy for multifocal motor neuropathy may reduce allergic adverse effects: A case report

Rinsho Shinkeigaku ◽

10.5692/clinicalneurol.50.561 ◽

2010 ◽

Vol 50 (8) ◽

pp. 561-565

Author(s):

Yoshiko Murata ◽

Tomoko Okamoto ◽

Yoshiyuki Kondo ◽

Norio Chihara ◽

Yoshihiko Furusawa ◽

...

Keyword(s):

Case Report ◽

Adverse Effects ◽

Maintenance Therapy ◽

Low Dose ◽

Multifocal Motor Neuropathy ◽

Motor Neuropathy

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COMPLETE MANAGEMENT OF ARDITA (BELL’S PALSY) AS PER AYURVEDA CHIKITSA SUTRA – A CASE REPORT

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2209032021 ◽

2021 ◽

Vol 09 (3) ◽

pp. 650-656

Author(s):

Ram Lakhan Meena ◽

Santoshkumar Bhatted ◽

Nilam Meena

Keyword(s):

Case Report ◽

Adverse Effects ◽

Facial Nerve ◽

Present Report ◽

Complete Recovery ◽

Bell’S Palsy ◽

Bell's Palsy ◽

Contemporary Science ◽

The Face ◽

Grading Scale

Bell’s palsy, also known as acute idiopathic lower motor neuron facial paralysis, is characterized by sud-den onset paralysis or weakness of the muscles to one side of the face controlled by the facial nerve. In contemporary science, administration of steroids is the treatment of choice for complete facial palsy. Cer-tain Panchakarma procedures and internal Ayurvedic medicines have been proved to be beneficial in the management of Ardita vata. The present report deals with a case of 62-year-old male patient diagnosed as Ardita vata was treated with various Panchakarma procedures like Nasya, Shirobasti, Kukkutanda Swedana, Dashmoola Ksheer Dhoom, Gandoosh and oral Ayurveda medicines. Criteria of assessment was based on the scoring of House-Brackmann Facial Nerve Grading scale. After completion of Ayurveda treatment, the patient Shown almost complete recovery without any adverse effects. This case is an evi-dence to demonstrate the effectiveness of Ayurveda treatment in case of Ardita vata (Bell’s palsy).

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Tacrolimus-induced bilateral optic neuropathy: A case report

Vojnosanitetski pregled ◽

10.2298/vsp201126004z ◽

2021 ◽

pp. 4-4

Author(s):

Lepsa Zoric ◽

Aleksandra Ilic ◽

Emina Colak ◽

Milos Mirkovic ◽

Jelica Pantelic ◽

...

Keyword(s):

Case Report ◽

Adverse Effects ◽

Optic Neuropathy ◽

Vision Loss ◽

White Male ◽

Immunosuppressive Drug ◽

Organ Rejection ◽

Toxic Optic Neuropathy ◽

Tacrolimus Therapy ◽

Male Patients

Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive drug with growing usage. It is usually used in prevention of transplanted organ rejection. Its use is highly valuable, but like other immunosupressants, it has adverse effects. One of them is optic neuropathy. Case report. A 47-year-old white male patients who had received tacrolimus therapy for nine years, after kidney transplantation, developed a subacute, painless vision loss on both eyes. He was thoroughly examined on different possible optic neuropathies and other causes of vision loss. After exclusion of other possible causes, the diagnosis of toxic optic neuropathy was established. His therapy was converted to cyclosporine, by his nephrologist, but his vision had improved only slightly. Conclusion. Toxic optic neuropathies are presented in everyday ophthalmological practice, but they are underestimated. Diagnosis can be demanding, especially when it comes to drugs and substances whose possible toxic effect on the optic nerve is not widely known. Unlike other adverse effects of tacrolimus therapy on nervous system, optic neuropathy can causes great and permanent functional impairment.

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