scholarly journals Will the Meikirch Model, a New Framework for Health, Induce a Paradigm Shift in Healthcare?

Cureus ◽  
2017 ◽  
Author(s):  
Johannes Bircher ◽  
Eckhart G Hahn
Keyword(s):  
Paradigm Shift ◽  
Meikirch Model ◽  
New Framework

scholarly journals Plastic Adaptation to Pathology in Psychiatry: Are Patients with Psychiatric Disorders Pathological Experts?

2019 ◽  
Vol 26 (3) ◽  
pp. 208-223
Author(s):  
Ali Amad ◽  
Paul Expert ◽  
Louis-David Lord ◽  
Thomas Fovet ◽  
Pierre A. Geoffroy
Keyword(s):  
Psychiatric Disorders ◽  
Chronic Inflammation ◽  
Gray Matter ◽  
Paradigm Shift ◽  
Psychiatric Symptoms ◽  
Brain Connectivity ◽  
Diagnosis And Treatment ◽  
Progressive Loss ◽  
The Brain ◽  
New Framework

Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution are currently studied under the deficit-oriented neuroprogression framework. Interestingly, considering the plasticity of the brain, it is also necessary to emphasize the bidirectional nature of neuroprogression. We review evidence highlighting alterations of the brain associated with the longitudinal evolution of psychiatric disorders from the framework of neuroplastic adaptation to pathology. This new framework highlights that substantial plasticity and remodeling may occur beyond the classic deficit-oriented neuroprogressive framework, which has been associated with progressive loss of gray matter thickness, decreased brain connectivity, and chronic inflammation. We also integrate the brain economy concept in the neuroplastic adaptation to pathology framework, emphasizing that to preserve its economy, i.e. function, the brain learns how to cope with the disease by adapting its architecture. Neuroplastic adaptation to pathology is a proposition for a paradigm shift to overcome the shortcomings of traditional psychiatric diagnostic boundaries; this approach can disentangle both the specific pathophysiology of psychiatric symptoms and the adaptation to pathology, thus offering a new framework for both diagnosis and treatment.

A Possible Paradigm Shift in Thinking About Thinking

1985 ◽  
Vol 30 (1) ◽  
pp. 17-17
Author(s):  
Marion Perlmutter
Keyword(s):  
Paradigm Shift

The Postindustrial Paradigm Shift: From Roles to Relationships

1994 ◽  
Vol 39 (2) ◽  
pp. 197-198
Author(s):  
Raymond T. Garza
Keyword(s):  
Paradigm Shift

Is It Time to Let Successful Aging Die? A New Framework for Understanding Human Development

2019 ◽  
Author(s):  
Lucas J. Hamilton ◽  
Michael T. Vale ◽  
Michelle L. Hughes ◽  
Paige M. Pasta ◽  
Katherine Judge
Keyword(s):  
Human Development ◽  
Successful Aging ◽  
New Framework
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