scholarly journals Regenerative Medicine for Knee Osteoarthritis – The Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: A Literature Review

Cureus ◽  
2020 ◽  
Author(s):  
Hoi Leng Ip ◽  
Debashis Kumar Nath ◽  
Safia H Sawleh ◽  
Md. Humayun Kabir ◽  
Nusrat Jahan
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Literature Review ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Efficacy And Safety

scholarly journals Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells for Regenerative Medicine-Associated Treatments in Bottlenose Dolphins (Tursiops truncatus)

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e108439 ◽  
Author(s):  
Richard J. Griffeth ◽  
Daniel García-Párraga ◽  
Maravillas Mellado-López ◽  
Jose Luis Crespo-Picazo ◽  
Mario Soriano-Navarro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Tursiops Truncatus ◽  
Platelet Rich Plasma ◽  
Bottlenose Dolphins

scholarly journals Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mikel Sánchez ◽  
Diego Delgado ◽  
Pello Sánchez ◽  
Emma Muiños-López ◽  
Bruno Paiva ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Platelet Rich Plasma ◽  
Joint Function ◽  
Novel Approach ◽  
New Strategy

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovial membrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma. We explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously. We assessed the clinical outcomes through osteoarthritis outcome score (KOOS) and the inflammatory response by quantifying mesenchymal stem cells in synovial fluid. There was a significant pain reduction in the KOOS from baseline(61.55±14.11)to week 24(74.60±19.19), after treatment(p=0.008), in the secondary outcomes (symptoms,p=0.004; ADL,p=0.022; sport/rec.,p=0.017; QOL,p=0.012), as well as VAS score (p<0.001) and Lequesne Index(p=0.008). The presence of mesenchymal stem cells in synovial fluid and colony-forming cells one week after treatment decreased substantially from7.98±8.21 MSC/μL to4.04±5.36 MSC/μL(p=0.019)and from601.75±312.30to139.19±123.61  (p=0.012), respectively. Intra-articular injections combined with intraosseous infiltrations of platelet rich plasma reduce pain and mesenchymal stem cells in synovial fluid, besides significantly improving knee joint function in patients with severe knee osteoarthritis. This trial is registered on EudraCT with the number2013-003982-32.

scholarly journals Efficacy and safety of intra-articular injection of mesenchymal stem cells in the treatment of knee osteoarthritis

Medicine ◽  
2020 ◽  
Vol 99 (49) ◽  
pp. e23343
Author(s):  
Wei Ma ◽  
Cuimiao Liu ◽  
Shilu Wang ◽  
Honghao Xu ◽  
Haichao Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Knee Osteoarthritis ◽  
Efficacy And Safety

scholarly journals Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review

2018 ◽  
Vol 1 (21;1) ◽  
pp. 229-242 ◽  
Author(s):  
Alaa Abd-Elsayed
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Knee Osteoarthritis ◽  
Amniotic Fluid ◽  
Platelet Rich Plasma ◽  
Review Article ◽  
Current Evidence ◽  
Cochrane Library ◽  
Inclusion Criteria

Background: Knee osteoarthritis (KOA) is a very challenging condition to treat and can be resistant to medications, procedures, and even surgery. Surgery may not be an option for some patients due to obesity or comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA. Objective: This is a review article to evaluate the current evidence about regenerative medicine therapies in the treatment of KOA. Study Design: A review article. Setting: A review of literature. Methods: An online search of PubMed and Cochrane Library databases between January 2006 and December 2016 was performed to search related articles using the keywords of “treatment, stem cell, knee osteoarthritis,” limited to the English language. The articles were then screened to make sure only articles fitting our inclusion criteria were included. Results: Our search obtained a total of 268 articles, but only 18 articles met the inclusion criteria and were included in the current study. Limitations: There is still limited evidence in literature about the efficacy of regenerative medicine in treating KOA. More large clinical trials are needed to confirm the evidence. Conclusion: The present investigation demonstrates that regenerative medicine technologies provide good evidence in the treatment of osteoarthritis (OA) of the knee, but greater in-depth study to explore a more ideal way to overcome present difficulties, including standardization of sources of cells, is warranted. Key words: Knee osteoarthritis, stem cell, treatment, platelet rich plasma, amniotic fluid, articular cartilage defect

scholarly journals Role of Autologous Adipose derived Mesenchymal Stem Cells and Platelet Rich Plasma in Knee Osteoarthritis

2017 ◽  
pp. 378-382
Author(s):  
Anant Marathe ◽  
Jaymesh Thadani ◽  
Prashant Kshatriya ◽  
Shivani Vakodikar ◽  
Rajni Vyas
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma
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