Integrated Analysis of Transcriptomic Data Reveals Key Anti-CKD Targets and Anti-ESRD Targets

2020 ◽  
Vol 66 (07/2020) ◽  
Author(s):  
Zhi-Wei Sun ◽  
Ling-Lin Li ◽  
Jian-Zhong Tang ◽  
Yan-Ping Yang ◽  
Yan-Chun Geng ◽  
...  
Keyword(s):  
Integrated Analysis ◽  
Transcriptomic Data

Abstract 3155: Integrated analysis of genomic and transcriptomic data in esophageal squamous cell carcinoma.

2013 ◽  
Author(s):  
Yukie Sato-Kuwabara ◽  
Fabio Albuquerque Marchi ◽  
Clóvis Klock ◽  
Cristovam Scapulatempo ◽  
Felipe Coimbra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Integrated Analysis ◽  
Transcriptomic Data

Toxicogenomic markers for corticosteroid treatment in beef cattle: Integrated analysis of transcriptomic data

2015 ◽  
Vol 77 ◽  
pp. 1-11 ◽  
Author(s):  
Sara Pegolo ◽  
Barbara Di Camillo ◽  
Clara Montesissa ◽  
Francesca Tiziana Cannizzo ◽  
Bartolomeo Biolatti ◽  
...  
Keyword(s):  
Beef Cattle ◽  
Corticosteroid Treatment ◽  
Integrated Analysis ◽  
Transcriptomic Data

scholarly journals Integrated Analysis of Proteomic and Transcriptomic Data Highlights Late Fetal Muscle Maturation Process

2018 ◽  
Vol 17 (4) ◽  
pp. 672-693 ◽  
Author(s):  
Valentin Voillet ◽  
Magali San Cristobal ◽  
Marie-Christine Père ◽  
Yvon Billon ◽  
Laurianne Canario ◽  
...  
Keyword(s):  
Integrated Analysis ◽  
Maturation Process ◽  
Transcriptomic Data ◽  
Fetal Muscle

scholarly journals Integrated analysis of Transcriptomic Data Reveal AP-1 as a Potential Regulation Hub in Inflammation Induced Hyperalgesia Rat

2021 ◽  
Author(s):  
Xiang Zhu ◽  
Feng Li ◽  
Miqun Wang ◽  
Huibin Su ◽  
Xuedong Wu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Signaling Pathways ◽  
Dorsal Root ◽  
Clinical Problem ◽  
Underlying Mechanism ◽  
Differentially Expressed ◽  
Integrated Analysis ◽  
Cutaneous Inflammation ◽  
Transcriptomic Data ◽  
Post Transcriptional Regulation

Abstract BackgroundInflammation associated chronic pain is a global clinical problem, affecting millions of people worldwide. However, the underlying mechanism of inflammation associated chronic pain remains unclear. Complete Freund's adjuvant (CFA) induced cutaneous inflammation rat has been widely used as an inflammation-induced pain hypersensitivity model.MethodsHerein, we presented a transcriptomic profile of CFA-induced rat dorsal root ganglion via an approach targeting gene expression, DNA methylation and post-transcriptional regulation.ResultsWe identified 418 differentially expressed mRNAs, 120 differentially expressed microRNAs and 2670 differentially methylated regions, which are all highly associated with multiple inflammation related pathways, including NF-κB signaling pathways and IFN signaling pathways. Integrated analysis further demonstrated that AP-1 network, which may work as a regulator of inflammation response, is sophisticatedly regulated at both transcriptomic and epigenetic level.ConclusionsWe believe our data will not only provide drug screening targets for treating chronic pain and inflammation, but also shed a light on the molecular network inflammation induced hyperalgesia.

Integrated analysis of diverse transcriptomic data from Arabidopsis reveals genetic markers that reliably and reproducibly respond to ionizing radiation

Gene ◽  
2013 ◽  
Vol 518 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Jin-Hong Kim ◽  
Ji Eun Kim ◽  
Min Hee Lee ◽  
Sun Woo Lee ◽  
Eun Ju Cho ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Genetic Markers ◽  
Integrated Analysis ◽  
Transcriptomic Data

Abstract 3427: Uncovering vulvar cancer: Integrated analysis of genomic and transcriptomic data

2014 ◽  
Author(s):  
André M. Lavorato-Rocha ◽  
Beatriz de Melo Maia ◽  
Iara S. Rodrigues ◽  
Fabio A. Marchi ◽  
Gabriel R. Fernandes ◽  
...  
Keyword(s):  
Vulvar Cancer ◽  
Integrated Analysis ◽  
Transcriptomic Data

Abstract 2285: Regtools: Integrated analysis of genomic and transcriptomic data for discovery of mutations associated with aberrant splicing in cancer

2018 ◽  
Author(s):  
Yang-Yang Feng ◽  
Avinash Ramu ◽  
Zachary L. Skidmore ◽  
Jason Kunisaki ◽  
Kelsy C. Cotto ◽  
...  
Keyword(s):  
Integrated Analysis ◽  
Aberrant Splicing ◽  
Transcriptomic Data

scholarly journals Integrated analysis of Transcriptomic Data Reveal AP-1 as a Potential Regulation Hub in Inflammation Induced Hyperalgesia Rat

2020 ◽  
Author(s):  
Xiang Zhu ◽  
Feng Li ◽  
Miqun Wang ◽  
Huibin Su ◽  
Xuedong Wu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Signaling Pathways ◽  
Dorsal Root ◽  
Clinical Problem ◽  
Underlying Mechanism ◽  
Differentially Expressed ◽  
Integrated Analysis ◽  
Cutaneous Inflammation ◽  
Transcriptomic Data ◽  
Post Transcriptional Regulation

Abstract Inflammation associated chronic pain is a global clinical problem, affecting millions of people worldwide. However, the underlying mechanism of inflammation associated chronic pain remains unclear. Complete Freund's adjuvant (CFA) induced cutaneous inflammation rat has been widely used as an inflammation-induced pain hypersensitivity model. Herein, we presented a transcriptomic profile of CFA-induced rat dorsal root ganglion via an approach targeting gene expression, DNA methylation and post-transcriptional regulation. We identified 418 differentially expressed mRNAs, 120 differentially expressed microRNAs and 2670 differentially methylated regions, which are all highly associated with multiple inflammation related pathways, including NF-κB signaling pathways and IFN signaling pathways. Integrated analysis further demonstrated that AP-1 network, which may work as a regulator of inflammation response, is sophisticatedly regulated at both transcriptomic and epigenetic level. We believe our data will not only provide drug screening targets for treating chronic pain and inflammation, but also shed a light on the molecular network inflammation induced hyperalgesia.

Sign in / Sign up

Export Citation Format

Share Document