scholarly journals Pharmacological Evaluation of Tamarix aphylla for Anti-inflammatory, Anti-pyretic and Anti-nociceptive Activities in Standard Animal Models

2017 ◽  
Author(s):  
A Iqbal ◽  
Siraj-ud-Din ◽  
I Khan ◽  
G Ali ◽  
Z Ur Rahman ◽  
...  
Keyword(s):  
Animal Models ◽  
Pharmacological Evaluation ◽  
Anti Inflammatory ◽  
Standard Animal

scholarly journals Anti-pyretic and anti-inflammatory activity of chloroform extract of Croton roxburghii in standard animal models

2008 ◽  
Vol 8 (3) ◽  
pp. 252-259 ◽  
Author(s):  
T Sivakumar ◽  
R Rajavel ◽  
D Karthikeyan ◽  
R Duraisamy ◽  
K Srinivasan ◽  
...  
Keyword(s):  
Animal Models ◽  
Chloroform Extract ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Standard Animal

Consideration of a Pharmacological Combinatorial Approach to Inhibit Chronic Inflammation in Alzheimer’s Disease

2019 ◽  
Vol 16 (11) ◽  
pp. 1007-1017 ◽  
Author(s):  
James G. McLarnon
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Chronic Inflammation ◽  
Preventive Strategy ◽  
Subsequent Work ◽  
Activated Microglia ◽  
Starting Point ◽  
Anti Inflammatory ◽  
Cocktail Approach

A combinatorial cocktail approach is suggested as a rationale intervention to attenuate chronic inflammation and confer neuroprotection in Alzheimer’s disease (AD). The requirement for an assemblage of pharmacological compounds follows from the host of pro-inflammatory pathways and mechanisms present in activated microglia in the disease process. This article suggests a starting point using four compounds which present some differential in anti-inflammatory targets and actions but a commonality in showing a finite permeability through Blood-brain Barrier (BBB). A basis for firstchoice compounds demonstrated neuroprotection in animal models (thalidomide and minocycline), clinical trial data showing some slowing in the progression of pathology in AD brain (ibuprofen) and indirect evidence for putative efficacy in blocking oxidative damage and chemotactic response mediated by activated microglia (dapsone). It is emphasized that a number of candidate compounds, other than ones suggested here, could be considered as components of the cocktail approach and would be expected to be examined in subsequent work. In this case, systematic testing in AD animal models is required to rigorously examine the efficacy of first-choice compounds and replace ones showing weaker effects. This protocol represents a practical approach to optimize the reduction of microglial-mediated chronic inflammation in AD pathology. Subsequent work would incorporate the anti-inflammatory cocktail delivery as an adjunctive treatment with ones independent of inflammation as an overall preventive strategy to slow the progression of AD.

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

2013 ◽  
Vol 16 (8) ◽  
pp. 740-748 ◽  
Author(s):  
Neelakandan Yuvaraj ◽  
Paulraj Kanmani ◽  
Ramraj Satishkumar ◽  
Alagesan Paari ◽  
Vellaiyan Pattukumar ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Sulfated Polysaccharides ◽  
Experimental Animal Models ◽  
Sargassum Wightii ◽  
Halophila Ovalis ◽  
Anti Inflammatory

scholarly journals Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents

2021 ◽  
Vol 116 ◽  
pp. 105346
Author(s):  
Zilan Song ◽  
Yuting Liu ◽  
Chenghu Xie ◽  
Xiankun Tong ◽  
Xue Wang ◽  
...  
Keyword(s):  
Side Chains ◽  
Pharmacological Evaluation ◽  
Anti Inflammatory

Evaluation of the Anti-inflammatory Activity of Luteolin in Experimental Animal Models

Planta Medica ◽  
2007 ◽  
Vol 73 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Li Ziyan ◽  
Zhou Yongmei ◽  
Zhang Nan ◽  
Tang Ning ◽  
Liu Baolin
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Inflammatory Activity ◽  
Experimental Animal Models ◽  
Anti Inflammatory
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