scholarly journals Evaluation of the Hypoglycaemic Activity of Petiveria alliacea (Guinea Hen Weed) Extracts in Normoglycaemic and Diabetic Rat Models

2014 ◽  
Vol 62 (8) ◽  
Author(s):  
S-L Christie ◽  
A Levy
Keyword(s):  
Diabetic Rat ◽  
Rat Models ◽  
Hypoglycaemic Activity ◽  
Petiveria Alliacea

scholarly journals Hypoglycaemic and hypolipidaemic activities of water extract of Lagerstroemia speciosa (L.) Pers. leaves in diabetic rat

2004 ◽  
Vol 2 (1) ◽  
pp. 15-23
Author(s):  
UDHI EKO HERNAWAN ◽  
SUTARNO SUTARNO ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Condensed Tannin ◽  
Fasting Blood Glucose ◽  
Water Extract ◽  
Diabetic Control ◽  
Total Phenol ◽  
Diabetic Rat ◽  
Lagerstroemia Speciosa ◽  
Hypoglycaemic Activity ◽  
Male Wistar Rats ◽  
Phytochemical Studies

The aim of this study was to know the hypoglycaemic and hypolipidaemic activities of water extract of bungur (Lagerstroemia speciosa [L.] Pers.) leaves in alloxan-induced diabetic rat. Phytochemical studies was conducted to determinate the tannin-contents of the water extract (WE). Male Wistar rats (150- 180 9 BW) were used in this study. The rats were divided into six groups: nonnal control; diabetic control; glibenclamide; WE 0.1 g/200 9 BW; WE 0.2 g/200 9 BW; and WE 0.5 g/200 9 BW. Dried leaves of bungur extracted with boiling water (50 g/L) for 30 minutes. The extract administered orally. Fasting blood glucose, triglyceride, and total cholesterol were determined at 0, 2, 4, 6 hours after treatment. Total phenol, ellagitannin, gallotannin, and condensed-tannin were determined from the WE. The results showed that WE exhibited hypoglycaemic activity at doses 0.2 g/200 9 BW and 0.5 g/200 9 BW. The last dose showed similar hypoglycaemic activity compared with glibenclamide. All doses showed the hypolipidaemic activity higher than glibenclamide. Phytochemical studies showed that the WE containing total phenol 0.025%; ellagitannin 0.011%; gallotannin 0.0199%; and condensed-tannin 0.0167%.

Effect of BRX-220 against Peripheral Neuropathy and Insulin Resistance in Diabetic Rat Models

2006 ◽  
Vol 967 (1) ◽  
pp. 482-489 ◽  
Author(s):  
MARIA KÜRTHY ◽  
TAMÁS MOGYORÓSI ◽  
KÁROLY NAGY ◽  
TIBOR KUKORELLI ◽  
ANDREA JEDNÁKOVITS ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Peripheral Neuropathy ◽  
Diabetic Rat ◽  
Rat Models

scholarly journals Experimental study on the effects of Kursi Ziyabet on the rat model of diabetes mellitus

2019 ◽  
Vol 02 (01) ◽  
pp. 7-11
Author(s):  
Alimjan Parhat ◽  
Haibaier Huojiaaihemaiti ◽  
Nabijan Mohammadturusn ◽  
Mammat Nurahmat
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Sugar ◽  
Water Intake ◽  
Fasting Blood Sugar ◽  
Diabetic Rat ◽  
Intragastric Administration ◽  
Model Group ◽  
Rat Models ◽  
Significant Difference

Objective: To evaluate the hyperglycemic effects of Kursi Ziyabet (KZ) tablets on the rat models of diabetes mellitus. Methods: In total, 58 male SD rats were assigned randomly to six groups. All except the normal group were transformed into experimental diabetes mellitus rat models by injecting streptozocin. The hyperglycemic effect and the mechanism of Ziyabet were evaluated by body weight, food and water intake, fasting blood sugar, and related parameters by measuring the oxidative stress-related factors and lipid metabolism indicator level by the corresponding kits using the rat experimental models. Results: Compared with the model group, body weight markedly increased after 3–6 weeks of intragastric administration of Ziyabet tablets ([Formula: see text]), while the water intake significantly decreased in the same period of time ([Formula: see text]). Food intake and fasting blood sugar level also decreased with the high dosage of Ziyabet tablets ([Formula: see text]). There is no significant difference in pancreas’ MDA content of the Ziyabet groups when compared to the model group ([Formula: see text]), while significant increase in SOD level was observed in high-dosage KZ group ([Formula: see text]). The blood serum insulin and free fatty acid level also decreased in the high-dosage KZ group compared with the model group ([Formula: see text]). Conclusion: We conclude that Ziyabet tablets demonstrated protective effects on the diabetic rat models.

scholarly journals Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin

2020 ◽  
Vol 28 (2) ◽  
pp. 479-487 ◽  
Author(s):  
Navid Neyshaburinezhad ◽  
Maryam Seidabadi ◽  
Mohammadreza Rouini ◽  
Hoda Lavasani ◽  
Alireza Foroumadi ◽  
...  
Keyword(s):  
Hepatic Clearance ◽  
Diabetic Rat ◽  
Type I ◽  
Type Ii ◽  
Rat Models ◽  
Before And After

scholarly journals High concentrations of peroxynitrite in sperm induce infertility on spontaneously diabetic rat models

2011 ◽  
Vol 356 (1) ◽  
pp. 223
Author(s):  
Jae Hee Yoon ◽  
Ji Sun Kim ◽  
Gun Hyun Park ◽  
Sung Hun Bae ◽  
Sung Won Kim ◽  
...  
Keyword(s):  
Diabetic Rat ◽  
Rat Models ◽  
High Concentrations

scholarly journals An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models

10.3791/55675 ◽  
2017 ◽  
Author(s):  
Yee Fun Lee ◽  
Chou-Ching Lin ◽  
Jung-Sung Cheng ◽  
Gin-Shin Chen
Keyword(s):  
Nerve Conduction ◽  
Conduction Block ◽  
Diabetic Rat ◽  
Rat Models ◽  
Nerve Conduction Block
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