Effect of Gongronema latifolium Ethanol Leaf Extract on Gastric Acid Secretion and Cytoprotection in Streptozotocin-induced Diabetic Rats

2012 ◽  
Vol 61 (9) ◽  
pp. 853-860 ◽  
Author(s):  
DU Owu ◽  
CR Nwokocha ◽  
AO Obembe ◽  
AD Essien ◽  
DE Ikpi ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Gongronema Latifolium

scholarly journals Gastric Ulceration in Diabetes Mellitus: Protective Role of Vitamin C

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel U. Owu ◽  
Agona O. Obembe ◽  
Chukwuemeka R. Nwokocha ◽  
Ime E. Edoho ◽  
Eme E. Osim
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin C ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Diabetic Control ◽  
Protective Role ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
And Control

The effect of vitamin C administration on gastric acid secretion and ulcer in diabetic rats was studied. Vitamin C (200 mg/kg b.w.) was administered to both streptozotocin-induced diabetic and control groups orally for 28 days. Gastric acid secretion was measured and ulcer was induced using ethanol. Histological changes were observed in the stomach. Basal and stimulated acid secretion in diabetic control rat was significantly () decreased when compared to vitamin C-treated diabetic group and control. Administration of vitamin C significantly () increased the histamine-stimulated gastric acid secretion in diabetics than control while reduction in gastric secretion by ranitidine was similar compared with control. Vitamin C treatment significantly () reduced ulcer index in diabetic group and increased mucus weight when compared with diabetic group which was also confirmed with photomicrographs. The mean body weight of diabetic rats treated with vitamin C was comparable to the control. The blood glucose level was significantly () reduced in diabetic group given vitamin C ( mMol/L) compared to the diabetic control ( g). It is concluded that vitamin C is beneficial in improving gastric acid secretion and protects against ulceration in streptozotocin-induced diabetes mellitus in rats due to its antioxidant potential.

scholarly journals Enhancement of Peptone-Induced Gastric Acid Secretion in Streptozotocin-Induced Diabetic Rats

2000 ◽  
Vol 84 (4) ◽  
pp. 405-411 ◽  
Author(s):  
Akinobu Fujita ◽  
Kimihito Tashima ◽  
Masato Nishijima ◽  
Koji Takeuchi
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Diabetic Rats

Basal and histamine-induced gastric acid secretion in alloxan diabetic rats

1993 ◽  
Vol 24 (1) ◽  
pp. 121-126 ◽  
Author(s):  
A.Tanju Özçeli̇kay ◽  
V.Meli̇h Altan ◽  
Nuray Yildizoǧlu-Ari ◽  
Orhan Altinkurt ◽  
Feyyaz Onur ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Diabetic Rats

Gastric acid secretion in streptozotocin-diabetic rats – Different responses to various secretagogues

2000 ◽  
Vol 94 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Kimihito Tashima ◽  
Masato Nishijima ◽  
Akinobu Fujita ◽  
Shoji Kawauchi ◽  
Koji Takeuchi
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Diabetic Rats ◽  
Streptozotocin Diabetic Rats
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