Computational prediction of microRNA for targeting HIV-1 and HIV-2 subtype

2013 ◽  
Author(s):  
Sitansu Kumar Verma ◽  
Shraddha ◽  
Ajay Kumar
Keyword(s):  
Computational Prediction ◽  
Hiv 1

scholarly journals Computational Prediction of HIV-1 Resistance to Protease Inhibitors

2016 ◽  
Vol 56 (5) ◽  
pp. 915-923 ◽  
Author(s):  
Ali Hosseini ◽  
Andreu Alibés ◽  
Marc Noguera-Julian ◽  
Victor Gil ◽  
Roger Paredes ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Computational Prediction ◽  
Hiv 1

Computational prediction of anti HIV-1 peptides andin vitroevaluation of anti HIV-1 activity of HIV-1 P24-derived peptides

2014 ◽  
Vol 21 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Naghmeh Poorinmohammad ◽  
Hassan Mohabatkar ◽  
Mandana Behbahani ◽  
Davood Biria
Keyword(s):  
Computational Prediction ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80562 ◽  
Author(s):  
Andrew L. Ferguson ◽  
Emilia Falkowska ◽  
Laura M. Walker ◽  
Michael S. Seaman ◽  
Dennis R. Burton ◽  
...  
Keyword(s):  
Computational Prediction ◽  
Activity Data ◽  
Neutralization Activity ◽  
Antibody Epitopes ◽  
Hiv 1

scholarly journals Custommune: a web tool to design personalized and population-targeted vaccine epitopes

2020 ◽  
Author(s):  
Mohammad Tarek ◽  
Mahmoud Elhefnawi ◽  
Juliana Terzi Maricato ◽  
Ricardo Sobhie Diaz ◽  
Iart Luca Shytaj ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Immune Escape ◽  
Rapid Development ◽  
Therapeutic Vaccine ◽  
Computational Prediction ◽  
Patient Specific ◽  
People Living With Hiv ◽  
Web Tool ◽  
Cell Immunity ◽  
Hiv 1

AbstractComputational prediction of immunogenic epitopes is a promising platform for therapeutic and preventive vaccine design. A potential target for this strategy is human immunodeficiency virus (HIV-1), for which, despite decades of efforts, no vaccine is available. In particular, a therapeutic vaccine devised to eliminate infected cells would represent a key component of cure strategies. HIV peptides designed based on individual viro-immunological data from people living with HIV/AIDS have recently shown able to induce post-therapy viral set point abatement. However, the reproducibility and scalability of this method is curtailed by the errors and arbitrariness associated with manual peptide design as well as by the time-consuming process.We herein introduce Custommune, a user-friendly web tool to design personalized and population-targeted vaccines. When applied to HIV-1, Custommune predicted personalized epitopes using patient specific Human Leukocyte Antigen (HLA) alleles and viral sequences, as well as the expected HLA-peptide binding strength and potential immune escape mutations. Of note, Custommune predictions compared favorably with manually designed peptides administered in a recent phase II clinical trial (NCT02961829).Furthermore, we utilized Custommune to design preventive vaccines targeted for populations highly affected by COVID-19. The results allowed the identification of peptides tailored for each population and predicted to elicit both CD8+ T-cell immunity and neutralizing antibodies against structurally conserved epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Overall, our data describe a new tool for rapid development of personalized or population-based immunotherapy against chronic and acute viral infections.

Ultrastructural observations of human monocytes infected with HIV-1

1991 ◽  
Vol 49 ◽  
pp. 108-109
Author(s):  
James K. Koehler ◽  
Steven G. Reed ◽  
Joao S. Silva
Keyword(s):  
Gradient Centrifugation ◽  
Virus Production ◽  
Human Monocyte ◽  
Red Cross ◽  
Human Monocytes ◽  
Blood Monocytes ◽  
Hiv Replication ◽  
Electron Microscopic ◽  
Ultrastructural Studies ◽  
Hiv 1

As part of a larger study involving the co-infection of human monocyte cultures with HIV and protozoan parasites, electron microscopic observations were made on the course of HIV replication and infection in these cells. Although several ultrastructural studies of the cytopathology associated with HIV infection have appeared, few studies have shown the details of virus production in “normal,” human monocytes/macrophages, one of the natural targets of the virus, and suspected of being a locus of quiescent virus during its long latent period. In this report, we detail some of the interactions of developing virons with the membranes and organelles of the monocyte host.Peripheral blood monocytes were prepared from buffy coats (Portland Red Cross) by Percoll gradient centrifugation, followed by adherence to cover slips. 90-95% pure monocytes were cultured in RPMI with 5% non-activated human AB serum for four days and infected with 100 TCID50/ml of HIV-1 for four hours, washed and incubated in fresh medium for 14 days.

Astrocytic adhesion molecules are increased in HIV-1-associated cognitive/motor complex

1997 ◽  
Vol 23 (3) ◽  
pp. 83-92 ◽  
Author(s):  
D. Seilhean ◽  
A. Dzia-Lepfoundzou ◽  
V. Sazdovitch ◽  
B. Cannella ◽  
C. S. Raine ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Motor Complex ◽  
Hiv 1

Ability of caregivers to read delayed hypersensitivity skin tests in children exposed to and infected by HIV*1

2000 ◽  
Vol 14 (2) ◽  
pp. 50-55
Author(s):  
FORTHEPEDIATRICPULMONARYANDCA ◽  
H COHEN ◽  
X CHEN ◽  
S SUNKLE ◽  
L DAVIS ◽  
...  
Keyword(s):  
Delayed Hypersensitivity ◽  
Skin Tests ◽  
Hypersensitivity Skin ◽  
Hiv 1
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