scholarly journals Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9675
Author(s):  
Huijuan Wang ◽  
Pingping Wang ◽  
Yu Wu ◽  
Xiukun Hou ◽  
Zechun Peng ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Normal Weight ◽  
Obese Group ◽  
Papillary Thyroid ◽  
Weight Group ◽  
Normal Weight Group ◽  
Advanced Tumor ◽  
Tumor Node Metastasis Stage ◽  
Overweight Group ◽  
The Relationship

Objective To explore the relationship between body mass index (BMI) and clinicopathological characteristics in patients with papillary thyroid carcinoma (PTC). Methods The clinical data of 1,579 patients with PTC, admitted to our hospital from May 2016 to March 2017, were retrospectively analyzed. According to the different BMI of patients, it can be divided into underweight recombination (BMI < 18.5 kg/m), normal body recombination (18.5 ≤ BMI < 24.0 kg/m2), overweight recombination (24.0 ≤ BMI < 28.0 kg/m2) and obesity group (BMI ≥ 28.0 kg/m2). The clinicopathological characteristics of PTC in patients with different BMIs group were compared. Results In our study, the risk for extrathyroidal extension (ETE), advanced T stage (T III/IV), and advanced tumor-node-metastasis stage (TNM III/IV) in the overweight group were higher, with OR (odds ratio) = 1.99(1.41–2.81), OR = 2.01(1.43–2.84), OR = 2.94(1.42–6.07), respectively, relative to the normal weight group. The risk for ETE and T III/IV stage in the obese group were higher, with OR = 1.82(1.23–2.71) and OR = 1.82(1.23–2.70), respectively, relative to the normal weight group. Conclusion BMI is associated with the invasiveness of PTC. There is a higher risk for ETE and TNM III/IV stage among patients with PTC in the overweight group and for ETE among patients with PTC in the obese group.

scholarly journals Obesity and Overweight Are Independently Associated with Greater Survival in Critically Ill Diabetic Patients: A Retrospective Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Wentao Huang ◽  
Yongsong Chen ◽  
Guoshu Yin ◽  
Nasui Wang ◽  
Chiju Wei ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Critically Ill ◽  
Cox Regression ◽  
Normal Weight ◽  
Diabetic Patients ◽  
Weight Group ◽  
Normal Weight Group ◽  
Obesity And Overweight ◽  
Overweight Group ◽  
The Relationship

Background. The relationship between obesity and the outcomes of critically ill diabetic patients is not completely clear. We aimed to assess the effects of obesity and overweight on the outcomes among diabetic patients in the intensive care unit (ICU). Methods. Critically ill diabetic patients in the ICU were classified into three groups according to their body mass index. The primary outcomes were 30-day and 90-day mortality. ICU and hospital length of stay (LOS) and incidence and duration of mechanical ventilation were also assessed. Cox regression models were developed to evaluate the relationship between obesity and overweight and mortality. Results. A total of 6108 eligible patients were included. The 30-day and 90-day mortality in the normal weight group were approximately 1.8 times and 1.5 times higher than in the obesity group and overweight group, respectively ( P < 0.001 , respectively). Meanwhile, the ICU (median (IQ): 2.9 (1.7, 5.3) vs. 2.7 (1.6, 4.8) vs. 2.8 (1.8, 5.0)) and hospital (median (IQ): 8.3 (5.4, 14.0) vs. 7.9 (5.1, 13.0) vs. 8.3 (5.3, 13.6)) LOS in the obesity group and overweight group were not longer than in the normal weight group. Compared with normal weight patients, obese patients had significantly higher incidence of mechanical ventilation (58.8% vs. 64.7%, P < 0.001 ) but no longer ventilation duration (median (IQ): 19.3 (7.0, 73.1) vs. 19.0 (6.0, 93.7), P = 1 ). Multivariate Cox regression showed that obese and overweight patients had lower 30-day (HR (95% CI): 0.62 (0.51, 0.75); 0.76 (0.62, 0.92), respectively) and 90-day (HR (95% CI): 0.60 (0.51, 0.70); 0.79 (0.67, 0.93), respectively) mortality risks than normal weight patients. Conclusions. Obesity and overweight were independently associated with greater survival in critically ill diabetic patients, without increasing the ICU and hospital LOS. Large multicenter prospective studies are needed to confirm our findings and the underlying mechanisms warrant further investigation.

scholarly journals Evaluation of adipokine chemerin in hypertensive obese

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Dalia Ramzy Ibrahim ◽  
Mervat Elsayed Taha ◽  
Amaal Mohamed Kamal
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Lipid Profile ◽  
Normal Weight ◽  
Obese Group ◽  
Weight Group ◽  
Normal Weight Group ◽  
Overweight Group ◽  
Hs Crp ◽  
Weight Groups

Chemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.            

scholarly journals Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yuan Hua Chen ◽  
Li Li ◽  
Wei Chen ◽  
Zhi Bing Liu ◽  
Li Ma ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Chinese Population ◽  
Linear Regression Analysis ◽  
Normal Weight ◽  
Obese Group ◽  
Large For Gestational Age ◽  
Weight Group ◽  
Normal Weight Group ◽  
Weight Groups

Abstract The association between suboptimal pre-pregnancy body mass index (BMI) and small-for-gestational-age (SGA) infants is not well defined. We investigated the association between pre-pregnancy BMI and the risk of SGA infants in a Chinese population. We performed a cohort study among 12029 mothers with a pregnancy. This cohort consisted of pregnant women that were: normal-weight (62.02%), underweight (17.09%), overweight (17.77%) and obese (3.12%). Birth sizes were reduced in the underweight and obese groups compared with the normal-weight group. Linear regression analysis indicated that birth size was positively associated with BMI in both the underweight and normal-weight groups. Further analysis showed that 12.74% of neonates were SGA infants in the underweight group, higher than 7.43% of neonates reported in the normal-weight group (adjusted RR = 1.92; 95% CI: 1.61, 2.30). Unexpectedly, 17.60% of neonates were SGA infants in the obese group, much higher than the normal-weight group (adjusted RR = 2.17; 95% CI: 1.57, 3.00). Additionally, 18.40% of neonates were large-for-gestational-age (LGA) infants in the obese group, higher than 7.26% of neonates reported in the normal-weight group (adjusted RR = 3.00; 95% CI: 2.21, 4.06). These results suggest that pre-pregnancy underweight increases the risk of SGA infants, whereas obesity increases the risks of not only LGA infants, but also SGA infants.

scholarly journals Effects of a Twelve-Week Weight Reduction Exercise Programme on Selected Spatiotemporal Gait Parameters of Obese Individuals

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Joseph A. Jegede ◽  
Babatunde O. A. Adegoke ◽  
Oladapo M. Olagbegi
Keyword(s):  
Weight Reduction ◽  
Step Length ◽  
Exercise Programme ◽  
Study Data ◽  
Normal Weight ◽  
Obese Group ◽  
Weight Group ◽  
Normal Weight Group ◽  
Gait Parameters ◽  
Quasi Experimental

Objectives. This study was carried out to investigate the effects of twelve-week weight reduction exercises on selected spatiotemporal gait parameters of obese individuals and compare with their normal weight counterparts. Methods. Sixty participants (30 obese and 30 of normal weight) started but only 58 participants (obese = 30, normal weight = 28) completed the quasi-experimental study. Only obese group had 12 weeks of weight reduction exercise training but both groups had their walking speed (WS), cadence (CD), step length (SL), step width (SW), and stride length (SDL) measured at baseline and at the end of weeks 4, 8, and 12 of the study. Data were analysed using appropriate descriptive and inferential statistics. Results. There was significantly lower WS, SL, and SDL but higher CD and SW in obese group than the normal weight group at baseline and week 12. However, the obese group had significantly higher percentage changes in all selected spatiotemporal parameters than the normal weight group. Conclusion. The 12-week weight reduction exercise programme produced significantly higher percentage changes in all selected spatiotemporal gait parameters in the obese than normal weight individuals and is recommended for improvement of these parameters among the obese individuals with gait related problems.

scholarly journals Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8317 ◽  
Author(s):  
Xiaowei Chen ◽  
Haixiang Sun ◽  
Fei Jiang ◽  
Yan Shen ◽  
Xin Li ◽  
...  
Keyword(s):  
Community Structure ◽  
Gut Microbiota ◽  
Statistical Difference ◽  
Normal Weight ◽  
Obese Group ◽  
Rrna Gene ◽  
Weight Group ◽  
Fecal Samples ◽  
Normal Weight Group ◽  
Gut Microbiota Dysbiosis

Background Obesity is a global epidemic in the industrialized and developing world, and many children suffer from obesity-related complications. Gut microbiota dysbiosis might have significant effect on the development of obesity. The microbiota continues to develop through childhood and thus childhood may be the prime time for microbiota interventions to realize health promotion or disease prevention. Therefore, it is crucial to understand the structure and function of pediatric gut microbiota. Methods According to the inclusion criteria and exclusion criteria, twenty-three normal weight and twenty-eight obese children were recruited from Nanjing, China. Genomic DNA was extracted from fecal samples. The V4 region of the bacterial 16S rDNA was amplified by PCR, and sequencing was applied to analyze the gut microbiota diversity and composition using the Illumina HiSeq 2500 platform. Results The number of operational taxonomic units (OTUs) showed a decrease in the diversity of gut microbiota with increasing body weight. The alpha diversity indices showed that the normal weight group had higher abundance and observed species than the obese group (Chao1: P < 0.001; observed species: P < 0.001; PD whole tree: P < 0.001; Shannon index: P = 0.008). Principal coordinate analysis (PCoA) and Nonmetric multidimensional scaling (NMDS) revealed significant differences in gut microbial community structure between the normal weight group and the obese group. The liner discriminant analysis (LDA) effect size (LEfSe) analysis showed that fifty-five species of bacteria were abundant in the fecal samples of the normal weight group and forty-five species of bacteria were abundant in the obese group. In regard to phyla, the gut microbiota in the obese group had lower proportions of Bacteroidetes (51.35%) compared to the normal weight group (55.48%) (P = 0.030). There was no statistical difference in Firmicutes between the two groups (P = 0.436), and the Firmicutes/Bacteroidetes between the two groups had no statistical difference (P = 0.983). At the genus level, Faecalibacterium, Phascolarctobacterium, Lachnospira, Megamonas, and Haemophilus were significantly more abundant in the obese group than in the normal weight group (P = 0.048, P = 0.018, P < 0.001, P = 0.040, and P = 0.003, respectively). The fecal microbiota of children in the obese group had lower proportions of Oscillospira and Dialister compared to the normal weight group (P = 0.002 and P = 0.002, respectively). Conclusions Our results showed a decrease in gut microbiota abundance and diversity as the BMI increased. Variations in the bacterial community structure were associated with obesity. Gut microbiota dysbiosis might play a crucial part in the development of obesity in Chinese children.

scholarly journals PL-014 The gaseous metabolism characteristics of overweight adult women during exercise stress test

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Shan Chen ◽  
Peizhen Zhang
Keyword(s):  
Stress Test ◽  
Exercise Stress Test ◽  
Normal Weight ◽  
Exercise Stress ◽  
Adult Women ◽  
Weight Group ◽  
Normal Weight Group ◽  
Overweight People ◽  
Gas Metabolism ◽  
Overweight Group

Objective Overweight was a global public health problem. In recent years, the number of overweight people in China had been increasing. Being overweight had a serious impact on health. 31.1% of overweight people had aggregation of risk factors for cardiovascular metabolic diseases. And overweight people were more likely to suffer from some diseases, such as hypertension, diabetes, dyslipidemia and arthritis. This study compared the gas metabolism index differences between overweight and normal weight women when they did exercise under different load, and summarized gas metabolism characteristics of overweight women, in order to lay the foundation for instructing overweight women to do exercise scientifically, reduce the risk factors of chronic diseases such as cardiovascular disease, and enhance and improve physical fitness and health. Methods Adult women between 20 and 30 years were taken as subjects. After measuring their height and weight, they were divided into normal weight group (BMI=18~23.9kg/m2) and overweight group (BMI＞24kg/m2) according to body mass index (BMI). There were 15 participants in each group. After the baseline test, using modified Bruce treadmill protocol, the air metabolism indexes of two groups were determined by Cortex MetaMax 3B portable gas metabolic analyzer, including oxygen uptake(VO2), minute ventilation(MV), breathing frequency(BF), expiratory end-tidal CO2concentration(ETCO2), expiratory end-tidal O2concentration (ETO2), arterial blood carbon dioxide partial pressure (PaCO2), carbon dioxide output(VCO2), oxygen pulse and maximal voluntary ventilation(MMV), etc. The differences of gas metabolism indexes among resting, exercise, and recovery stages were compared and analyzed. Results (1) Most of indexes such as VO2, VCO2, and MV rose gradually with the load increase during exercise stress test except for ETO2and PaCO2. VO2, PaCO2, VCO2and ETCO2of overweight group were significantly lower than normal weight group during the same load. PaCO2of overweight group at grade 4 was significant lower than normal weight group by 5.6 mmHg (P<0.05). VCO2of overweight group at grade 5 was significant lower than normal weight group by 0.6L/min (P<0.05). ETCO2 of overweight group at grade 3 and 4 were significant lower than normal weight group about 0.5% and 0.6% respectively (P<0.05). (2) During recovery stage, most of indexes decreased gradually, such as MV and BF, while ETO2presented a rising trend. At a certain time during the recovery stage, ETCO2of overweight group was significantly lower than normal weight group (5.3% vs 5.8%), while MMV, MV and oxygen pulse were significantly higher than normal weight group (P<0.05). MMV of overweight group at 2, 3 and 4 minutes were significant lower than normal weight group by1L/min, 1L/min and 0.9L/min, at the same time, MV of overweight group were significant lower than normal weight group by17.8L/min, 20.1L/min and 16.9L/min. The oxygen pulse of overweight group during whole 5 minutes recovery period were significantly higher than normal weight group by 2.7L/min, 3.9L/min, 3.9L/min, 2.9L/min and 2.0L/min. (3) The gaseous metabolism between two groups was significantly different when they did 7.1 and 10.2 METs exercise. Conclusions Although there was no difference in gas metabolism between overweight and normal weight adult women in resting state, the respiratory function of overweight women was weaker than normal weight women during exercise, especially at the intensities of 7.1 and 10.2 METs. During the recovery period after exercise stress test, the recovery rate of gas metabolism in overweight adult women was slower than that of normal weight women.

scholarly journals Obesity and left ventricular mass in children

2015 ◽  
Vol 55 (4) ◽  
pp. 224
Author(s):  
Mauliza Mauliza ◽  
Muhammad Ali ◽  
Melda Deliana ◽  
Tina Christina L Tobing
Keyword(s):  
Left Ventricular Mass ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Normal Weight ◽  
Obese Group ◽  
Internal Diameter ◽  
Weight Group ◽  
Normal Weight Group ◽  
Ventricular Mass ◽  
Moderate Positive Correlation

Background Obesity has negative effects on cardiac function during growth leading to increased heart size and mass, as a result of higher stroke volume and cardiac output.Objective To assess for a relationship between obesity and left ventricular mass (LVM) in children, as well as to assess for a correlation between the duration of obesity and LVM.Methods This cross-sectional study was conducted from October 2011 until February 2012 in Medan and included 30 obese and 30 normal weight children, aged 6 to 13 years. All subjects underwent complete echocardiography examinations to assess LVM and other left ventricular parameters. The Devereux formula was used to measure LVM.Results During the study, 65 children underwent echocardiography, but 5 were subsequently excluded. The left ventricular dimensions in the obese group were significantly higher compared to normal weight group with regards to interventricular septum at end diastole (IVSd), interventricular septum at end systole (IVSS), left ventricular internal diameter at end diastole (LVIDd), left ventricular internal diameter at end systole (LVIDs), left ventricular posterior wall thickness at end diastole (LVPWd), left ventricular mass (LVM), and left ventricular mass index (LVMI) (P=0.0001). Duration of obesity and LVM had a moderate, positive correlation (r=0.407).Conclusion There is significantly higher LVM in the obese group than in the normal weight group. The duration of obesity had a moderate, positive correlation to LVM.

scholarly journals Influence of Morbid Obesity on the Single-Dose Pharmacokinetics of Daptomycin

2007 ◽  
Vol 51 (8) ◽  
pp. 2741-2747 ◽  
Author(s):  
Manjunath P. Pai ◽  
Jeffrey P. Norenberg ◽  
Tamara Anderson ◽  
Diane W. Goade ◽  
Keith A. Rodvold ◽  
...  
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Bacterial Infections ◽  
Normal Weight ◽  
Obese Group ◽  
Pharmacokinetic Parameters ◽  
Morbidly Obese ◽  
Maximum Plasma ◽  
Weight Group ◽  
Normal Weight Group

ABSTRACT The present study characterized the single-dose pharmacokinetics of daptomycin dosed as 4 mg/kg of total body weight (TBW) in seven morbidly obese and seven age-, sex-, race-, and serum creatinine-matched healthy subjects. The glomerular filtration rate (GFR) was measured for both groups following a single bolus injection of [125I]sodium iothalamate. Noncompartmental analysis was used to determine the pharmacokinetic parameters, and these values were normalized against TBW, ideal body weight (IBW), and fat-free weight (FFW) for comparison of the two groups. All subjects enrolled in this study were female, and the mean (±standard deviation) body mass index was 46.2 ± 5.5 kg/m2 or 21.8 ± 1.9 kg/m2 for the morbidly obese or normal-weight group, respectively. The maximum plasma concentration and area under the concentration-time curve from dosing to 24 h were approximately 60% higher (P < 0.05) in the morbidly obese group than in the normal-weight group, and these were a function of the higher total dose received in the morbidly obese group. No differences in daptomycin volume of distribution (V), total clearance, renal clearance, or protein binding were noted between the two groups. Of TBW, FFW, or IBW, TBW provided the best correlation to V. In contrast, TBW overestimated GFR through creatinine clearance calculations using the Cockcroft-Gault equation. Use of IBW in the Cockcroft-Gault equation or use of the four-variable modification of diet in renal disease equation best estimated GFR in morbidly obese subjects. Further studies of daptomycin pharmacokinetics in morbidly obese patients with acute bacterial infections and impaired renal function are necessary to better predict appropriate dosage intervals.

scholarly journals The Association between Childhood Overweight and Reflux Esophagitis

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Nirav R. Patel ◽  
Mary J. Ward ◽  
Debra Beneck ◽  
Susanna Cunningham-Rundles ◽  
Aeri Moon
Keyword(s):  
Early Recognition ◽  
Retrospective Chart Review ◽  
Childhood Overweight ◽  
Normal Weight ◽  
Weight Group ◽  
Normal Weight Group ◽  
Significant Difference ◽  
Overweight Group ◽  
And Gender ◽  
Overweight Subjects

Background. In adults, it has been shown that obesity is associated with gastroesophageal reflux disease (GERD) and GERD-related complications. There are sparse pediatric data demonstrating associations between childhood overweight and GERD.Objective. To investigate the association between childhood overweight and RE.Methods. We performed a retrospective chart review of 230 children (M :  : 116) who underwent esophagogastroduodenoscopy (EGD) with biopsies between January 2000 and April 2006. Patient demographics, weight, height, clinical indications for the procedure, the prevalence of BMI classification groups, the prevalence of RE and usage of anti-reflux medications were reviewed. For these analyses, the overweight group was defined to include subjects with 85th percentile. The normal weight group was defined to include subjects with BMI 5th to 85th percentile.Results. Among the 230 subjects, 67 (29.1%) had BMI percentiles above the 85th percentile for age and gender. The prevalence of RE in the overweight group did not differ significantly from that in the normal weight group (23.9% versus 24.5%, resp.). Overweight subjects taking anti-reflux medications clearly demonstrated a higher prevalence of biopsy-proven RE compared to overweight subjects not taking anti-reflux medications (34.1% versus 7.7%, ).Conclusions. There was no significant difference in the prevalence of biopsy-proven RE in the overweight group compared to the normal weight group. However, the prevalence of RE was significantly higher in overweight subjects on anti-reflux medications compared to overweight subjects not taking anti-reflux medications. This finding emphasizes the importance of early recognition and treatment of GERD for the overweight pediatric patients with symptoms in conjunction with weight loss program for this population to reduce long-term morbidities associated with GERD.

scholarly journals Influence of preoperative weight on the early and middle outcome of fixed platform medial unicompartmental knee arthroplasty

2020 ◽  
Vol 8 (9_suppl7) ◽  
pp. 2325967120S0054
Author(s):  
Chen Wenzhong ◽  
Zou Shiping ◽  
Siwen Teng
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Normal Weight ◽  
Obese Group ◽  
Weight Group ◽  
P Values ◽  
Overweight Group ◽  
Hss Score ◽  
Incision Healing

Introduction: Obesity is an important independent risk factor for the development of knee osteoarthritis .According to the data of the world Health Organization, there were more than 1.9 billion overweight adults in the world in 2014, among which at least 600 million were clinically obese .Therefore, among the patients undergoing knee replacement, the number of obese patients is increasing .The use of single condyle replacement for medial compartment arthritis of the knee began in the 1970s.With the continuous development of new implants, the continuous improvement of surgical techniques and the strict control of indications by surgeons, the 15-year survival rate of single condyle replacement is over 90%, and the 20-year survival rate is 84%, achieving good results.In the indications of knee monocepicondylar replacement, the maximum weight standard has been increased from 82kg in 1989 [8] to 90kg in 2002 [9].However, there is still controversy over the body weight cut-off point in the indications, especially the observation on the postoperative effect of single condyle replacement in obese patients, which has been rarely reported in China. Hypotheses: To evaluate the near and middle term efficacy of unicompartmental knee arthroplasty(UKA) in patients with medial knee osteoarthritis with different body mass index, and to determine the effect of body weight on the efficacy and complications of UKA. Methods: A total of 128 patients who underwent UKA in department I of arthropathy, zhengzhou orthopaedic hospital from December 2016 to December 2018 due to medial knee osteoarthritis were included as study subjects, and the clinical data of the study subjects were retrospectively analyzed. There were 29 males and 99 females, with an average age of 65.13± 7.37 years (range: 51˜87 years).According to the preoperative body mass index (BMI), the subjects were divided into three groups, namely the underweight or normal weight group (BMI < 24kg /㎡), the overweight group (24kg /㎡≤BMI < 28kg /㎡) and the obese group (BMI≥ 28kg /㎡).Visual analogue scale (VAS), knee range of motion(ROM), American hospital for special surgery (HSS) score of knee joint, complications and other relevant indicators were recorded before and at the last follow-up for each group. According to the data types of preoperative and postoperative efficacy evaluation indexes of the same group, paired sample T test, c² test or Wilcoxon sign rank sum test were used for difference analysis. One-way anova, c² test or K-W rank sum test were used to evaluate the difference between groups. Results: All subjects were followed up for 13-37 months (22.34± 7.22).Compared with before surgery, VAS scores of patients in the last follow-up were significantly lower in the underweight or normal weight group, the overweight group and the obese group (6.91±6.34 vs. 0.44±0.67, 6.90 ±0.77 vs. 0.63±0.68, 6.78±0.71 vs. 0.59±0.61) (t= 46.488-42.654,P values <0.01), knee ROM significantly increased (97.67±10.87 vs. 114.77±8.01, 98.96±10.67 vs. 116.03±6.96, 95.31±11.50 vs. 110.93±11.46) (t= -20.83 - -11.039,All P values were <0.01), and knee HSS score was significantly improved (51.63±0.61 vs 88.00±4.06, 50.68±6.46 vs 87.87±5.73, 48.25±6.70 vs 87.03±5.17) (t= -48.920- -34.010, all P values <0.01).There were no statistically significant differences in VAS score, knee ROM and knee HSS score between the overweight group and the obese group compared with the underweight or normal group. None of the patients had serious complications such as periprosthesis infection, simple prosthesis loosening and periprosthesis fracture. The incidence of venous thrombosis in lower extremities was 14.06% (18/128), with no significant difference between groups. There were 7 cases of poor incision healing (overweight group is 3 and obese group is 4), and the risk of poor incision healing was higher in the obese group than in the underweight or normal weight group, with statistical significance (P=0.03). Conclusion: UKA can achieve satisfactory clinical effect in patients with different body mass index, but patients in obesity group are prone to complications such as poor incision healing.

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