scholarly journals Wedge resection is equal to segmental resection for pulmonary typical carcinoid patients at localized stage: a population-based analysis

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7519
Author(s):  
Tao Yan ◽  
Kai Wang ◽  
Jichang Liu ◽  
Yukai Zeng ◽  
Fenglong Bie ◽  
...  
Keyword(s):  
Wedge Resection ◽  
Clinical Information ◽  
Population Based ◽  
Segmental Resection ◽  
Chi Square ◽  
Typical Carcinoid ◽  
Medical Institutions ◽  
Significant Independent Prognostic Factor ◽  
Chi Square Test ◽  
Patient Prognosis

Background Medical institutions worldwide have not reached a consensus on what surgery is the most advisable for pulmonary typical carcinoid (TC) patients at the localized stage. This research focuses on exploring whether wedge resection or segmental resection is the superior option. Methods The demographic and clinical information of 1,887 TC patients diagnosed at the localized stage from 2004 to 2015 was collected from the Surveillance, Epidemiology, and End Results (SEER) Program. Patient prognosis was evaluated by KM curves. The chi-square test was used to examine the variation between different groups that would be eliminated by propensity score matching (PSM). Univariate and multivariate Cox proportional hazard model analyses were used to evaluate prognostic values of relative factors. Results The prognosis of TC was the most favorable for patients suffering from pulmonary squamous cell carcinoma (SCC), adenocarcinoma (ADC), and pulmonary carcinoids (PCs). The choice to have surgery, not the type of surgery chosen, was the most significant independent prognostic factor correlated with overall survival (OS) and lung cancer-special survival (LCSS). The prognostic result of the comparison between wedge resection and segmental resection was not statistically significant before or after PSM. In subgroup analysis, the inference still held.

scholarly journals Changes in cannabis use according to socioeconomic status among Finnish adolescents from 2000 to 2015

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Noora Knaappila ◽  
Mauri Marttunen ◽  
Sari Fröjd ◽  
Nina Lindberg ◽  
Riittakerttu Kaltiala
Keyword(s):  
Socioeconomic Status ◽  
Parental Education ◽  
Population Based ◽  
Cannabis Use ◽  
Chi Square ◽  
Socioeconomic Groups ◽  
Parental Unemployment ◽  
The Usa ◽  
Chi Square Test ◽  
School Survey

Abstract Background Despite reduced sanctions and more permissive attitudes toward cannabis use in the USA and Europe, the prevalences of adolescent cannabis use have remained rather stable in the twenty-first century. However, whether trends in adolescent cannabis use differ between socioeconomic groups is not known. The aim of this study was to examine trends in cannabis use according to socioeconomic status among Finnish adolescents from 2000 to 2015. Methods A population-based school survey was conducted biennially among 14–16-year-old Finns between 2000 and 2015 (n = 761,278). Distributions for any and frequent cannabis use over time according to socioeconomic adversities were calculated using crosstabs and chi-square test. Associations between any and frequent cannabis use, time, and socioeconomic adversities were studied using binomial logistic regression results shown by odds ratios with 95% confidence intervals. Results At the overall level, the prevalences of lifetime and frequent cannabis use varied only slightly between 2000 and 2015. Cannabis use was associated with socioeconomic adversities (parental unemployment in the past year, low parental education, and not living with both parents). The differences in any and frequent cannabis use between socioeconomic groups increased significantly over the study period. Conclusions Although the overall changes in the prevalence of adolescent cannabis use were modest, cannabis use increased markedly among adolescents with the most socioeconomic adversities. Socioeconomic adversities should be considered in the prevention of adolescent cannabis use.

scholarly journals Changes in Six-Month Prevalence of Circulatory System Diseases among People Aged 20 Years and Older between 2013 and 2018 in Hunan, China

2021 ◽  
Vol 18 (5) ◽  
pp. 2599
Author(s):  
Zhenzhen Rao ◽  
Junjie Hua ◽  
Ruotong Li ◽  
Yanhong Fu ◽  
Jie Li ◽  
...  
Keyword(s):  
Age Groups ◽  
Circulatory System ◽  
Population Based ◽  
Hunan Province ◽  
Rural Residents ◽  
Chi Square ◽  
Circulatory System Diseases ◽  
Chi Square Test ◽  
Urban Rural ◽  
Socio Demographic Factors

Recent changes in population-based prevalence for circulatory system diseases (CSDs) remain unreported either nationally or locally for China. Data were from the two-round health service household interview survey of Hunan Province, China, in 2013 and 2018. A Rao–Scott chi-square test was performed to examine prevalence differences across socio-demographic variables. The overall age-standardized prevalence of CSDs increased substantially between 2013 and 2018 for inhabitants aged 20 years and older (14.25% vs. 21.25%; adjusted odds ratio (OR) = 1.59, 95% CI: 1.24–2.04). Hypertensive disease was the most prevalent type of CSD, accounting for 87.24% and 83.83% of all CSDs in 2013 and in 2018, respectively. After controlling for other socio-demographic factors, the prevalence of CSDs was significantly higher in 2018 (adjusted OR = 1.40), urban residents (adjusted OR = 1.43), females (adjusted OR = 1.12) and older age groups (adjusted OR = 5.36 for 50–59 years, 9.51 for 60–69 years, 15.19 for 70–79 years, and 12.90 for 80 years and older) than in 2013, rural residents, males and the youngest age group (20–49 years). The recent increase in the overall age-standardized CSD prevalence and the large prevalence disparities across urban/rural residents, sex and age groups merit the attention of policymakers and researchers. Further prevention efforts are needed to curb the increasing tendency and to reduce the prevalence of disparities across socio-demographic groups.

scholarly journals Feedback of patient survey on medication improves the management of polypharmacy: a pilot trial

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yuta Hirose ◽  
Kiyoshi Shikino ◽  
Yoshiyuki Ohira ◽  
Sumihide Matsuoka ◽  
Chihiro Mikami ◽  
...  
Keyword(s):  
Health Professionals ◽  
Questionnaire Survey ◽  
Pilot Trial ◽  
Patient Survey ◽  
Contributing Factors ◽  
Chi Square ◽  
Oral Medications ◽  
Medical Institutions ◽  
Chi Square Test ◽  
Survey Results

Abstract Background Patient awareness surveys on polypharmacy have been reported previously, but no previous study has examined the effects of sending feedback to health professionals on reducing medication use. Our study aimed to conduct a patient survey to examine factors contributing to polypharmacy, feedback the results to health professionals, and analyze the resulting changes in the number of polypharmacy patients and prescribed medications. Methods After conducting a questionnaire survey of patients in Study 1, we provided its results to the healthcare professionals, and then surveyed the number of polypharmacy patients and oral medications using a before-after comparative study design in Study 2. In Study 1, we examined polypharmacy and its contributing factors by performing logistic regression analysis. In Study 2, we performed a t-test and a chi-square test. Results In the questionnaire survey, significant differences were found in the following 3 items: age (odds ratio (OR) = 3.14; 95% confidence interval (CI) = 2.01–4.91), number of medical institutions (OR = 2.34; 95%CI = 1.50–3.64), and patients’ difficulty with asking their doctors to deprescribe their medications (OR = 2.21; 95%CI = 1.25–3.90). After the feedback, the number of polypharmacy patients decreased from 175 to 159 individuals and the mean number of prescribed medications per patient decreased from 8.2 to 7.7 (p < 0.001, respectively). Conclusions Providing feedback to health professionals on polypharmacy survey results may lead to a decrease in the number of polypharmacy patients. Factors contributing to polypharmacy included age (75 years or older), the number of medical institutions (2 or more institutions), and patients’ difficulty with asking their physicians to deprescribe their medications. Feedback to health professionals reduced the percentage of polypharmacy patients and the number of prescribed medications. Trial registration UMIN. Registered 21 June 2020 - Retrospectively registered, https://www.umin.ac.jp/ctr/index-j.htm

scholarly journals Shift Work and Dry Eye Disease in the Korean Working Population: A Population-Based Cross-Sectional Study

2021 ◽  
Vol 18 (10) ◽  
pp. 5492
Author(s):  
Joonho Ahn ◽  
So-Jung Ryu ◽  
Jihun Song ◽  
Hyoung-Ryoul Kim
Keyword(s):  
Shift Work ◽  
Dry Eye ◽  
Population Based ◽  
Cross Sectional Study ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Chi Square ◽  
Cross Sectional ◽  
Shift Workers ◽  
Chi Square Test

This study aimed to evaluate the association between shift work and dry eye disease (DED) in the general population. The 2011 Korea Health Panel (KHP) was used. Chi-square test and multivariate logistic regression were used to assess the relationship between shift work and DED. Stratification analysis was conducted by sex and age. Overall, the odds ratio (OR) of DED according to shift work did not showed significant results (adjusted OR = 1.230, 95% CI 0.758–1.901). When findings were stratified based on age older or younger than 40 years, the OR of DED increased to 2.85 (95% CI: 1.25–5.90) in shift workers under 40 years of age. Our results show an association between shift work and DED in a group of younger subjects.

scholarly journals Exploring the association between adverse maternal circumstances and low birth weight in neonates: a nationwide population-based study in Bangladesh

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e036162
Author(s):  
Md Mostaured Ali Khan ◽  
Md Golam Mustagir ◽  
Md Rafiqul Islam ◽  
Md Sharif Kaikobad ◽  
Hafiz TA Khan
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Rural Areas ◽  
Partner Violence ◽  
Multivariate Logistic Regression Analysis ◽  
Population Based ◽  
Chi Square ◽  
The Sustainable Development ◽  
Chi Square Test ◽  
Study Designs

ObjectiveThis study is concerned with helping to improve the health and care of newborn babies in Bangladesh by exploring adverse maternal circumstances and assessing whether these are contributing towards low birth weight (LBW) in neonates.Study designs and settingsData were drawn and analysed from the Bangladesh Demographic and Health Survey, 2014. Any association between LBW and adverse maternal circumstances were assessed using a Chi-square test with determinants of LBW identified by multivariate logistic regression analysis.ParticipantsThe study is based on 4728 children aged below 5 years and born to women from selected households.ResultsThe rate of LBW was around 19.9% (199 per 1000 live births) with the highest level found in the Sylhet region (26.2%). The rate was even higher in rural areas (20.8%) and among illiterate mothers (26.6%). Several adverse maternal circumstances of the women included in the survey were found to be significant for increasing the likelihood of giving birth to LBW babies. These circumstances included the women being underweight (adjusted odds ratio (AOR) 1.26, 95% CI 1.06 to 1.49); having unwanted births (AOR 1.22, 95% CI 1.03 to 1.44); had previous pregnancies terminated (AOR 1.28, 95% CI 1.05 to 1.57); were victims of intimate partner violence (AOR 1.23, 95% CI 1.05 to 1.45) and taking antenatal care <4 times (AOR 1.23, 95% CI 1.03 to 1.48). Other important risk factors that were revealed included age at birth <18 years (AOR 1.42, 95% CI 1.11 to 1.83) and intervals between the number of births <24 months (AOR 1.25, 95% CI 1.01 to 1.55). When taking multiple fertility behaviours together such as, the ages of the women at birth (<18 years with interval <24 months (AOR 1.26, 95% CI 1.02 to 1.57) and birth order (>3 with interval <24 months (AOR 1.68, 95% CI 1.18 to 2.37), then the risk of having LBW babies significantly increased.ConclusionThis study finds that adverse maternal circumstances combined with high-risk fertility behaviours are significantly associated with LBW in neonates. This situation could severely impede progress in Bangladesh towards achieving the sustainable development goal concerned with the healthcare of newborns.

scholarly journals Online Suicide Identification in the Framework of Rhetorical Structure Theory (RST)

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 847
Author(s):  
Xingyun Liu ◽  
Xiaoqian Liu
Keyword(s):  
Suicide Prevention ◽  
Suicide Ideation ◽  
Population Based ◽  
Structure Theory ◽  
Context Analysis ◽  
Chi Square ◽  
Rhetorical Structure ◽  
Chi Square Test ◽  
Ideation Methods ◽  
Rhetorical Structures

Background: Suicide is a serious social problem. Substantial efforts have been made to prevent suicide for many decades. The internet has become an important arena for suicide prevention and intervention. However, to the best of our knowledge, only one study has analyzed suicidal comments online from the perspective of rhetorical structure with incomplete rhetorical relations. We aimed to examine the rhetorical differences between Chinese social media users who died by suicide and those without suicidal ideation. Methods: The posts of 15 users who died by suicide and 15 not suffering from suicide ideation were annotated by five postgraduates with expertise in analyzing suicidal posts based on rhetorical structure theory (RST). Group differences were compared via a chi-square test. Results: Results showed that users who died by suicide posted significantly more posts and used more rhetorical relations. Moreover, the two groups displayed significant differences in 17 out of 23 rhetorical relations. Limitations: Because this study is largely exploratory and tentative, caution should be taken in generalizing our findings. Conclusions: Our results expand the methods of RST to the online suicidal identification field. There are implications for population-based suicide prevention by combining rhetorical structures with context analysis.

Uptake and effectiveness of FOLFIRINOX for advanced pancreas cancer: A population-based study.

2017 ◽  
Vol 35 (8_suppl) ◽  
pp. 245-245
Author(s):  
Safiya Karim ◽  
Jina Zhang-Salomons ◽  
James Joseph Biagi ◽  
Tim Asmis ◽  
Christopher M. Booth
Keyword(s):  
General Population ◽  
Pancreas Cancer ◽  
Study Groups ◽  
Median Number ◽  
Population Based ◽  
Routine Practice ◽  
Chi Square ◽  
Palliative Intent ◽  
Funding Program ◽  
Chi Square Test

245 Background: While FOLFIRINOX is a standard treatment option for advanced pancreas cancer there is little data describing utilization and effectiveness in routine clinical practice. Here we report practice patterns and outcomes in the general population of Ontario, Canada. Methods: Using the Ontario Cancer Registry and New Drug Funding Program we identified all patients with pancreas cancer treated with palliative intent gemcitabine or FOLFIRINOX in Ontario during 2006-2014. FOLFIRINOX became available in Ontario’s single-payer health system in November 2011. Gemcitabine cases were classified as pre-FOLFIRINOX era (2006-2010) or post-FOLFIRINOX era (2011-2014). Cases treated with peri-operative chemotherapy were excluded. Comparisons of proportions between study groups were made using the chi-square test. Overall survival (OS) was measured from date of chemotherapy initiation. Results: During 2006-2014, 3826 patients in Ontario were treated with Gemcitabine (n=3042) or FOLFIRINOX (n=784) chemotherapy for advanced pancreas cancer. Uptake of FOLFIRINOX increased from 41% (206/505) of treated cases in 2012 to 56% (274/486) of treated cases in 2014. Among patients treated after 2011, median age was 69 and 63 years for Gemcitabine and FOLFIRINOX respectively (p<0.001). The proportion of treated cases who received FOLFIRINOX varied considerably across geographic regions (from 26% to 58%, p<0.001). Median number of FOLFIRINOX cycles delivered was 6 (median 10 cycles in pivotal RCT). Median OS of patients treated with Gemcitabine was 5.0 months in 2006-2010 and 4.8 months in 2011-2014. Median OS of FOLFIRINOX patients treated in 2011-2014 was 8.2 months (median 11.1 months in pivotal RCT). Conclusions: Use of FOLFIRINOX in the general population has increased since 2011 with a resulting decrease in use of Gemcitabine. However, outcomes achieved with FOLFIRINOX in Ontario demonstrate a substantial efficacy-effectiveness gap between survival in the pivotal clinical trial and survival in routine practice.

scholarly journals Urological Sarcoma Among the Iranian Population; A National Registry-Based Study

2020 ◽  
Vol 13 (12) ◽  
Author(s):  
Mohammad Ali Ganji Jameshouran ◽  
Farzad Allameh ◽  
Mohammad Mersad Mansouri Tehrani ◽  
Mohammad Ali Tasharrofi ◽  
Babak Javanmard ◽  
...  
Keyword(s):  
Soft Tissue Sarcomas ◽  
Population Based ◽  
National Registry ◽  
Patient Data ◽  
Iranian Population ◽  
Genitourinary Tract ◽  
Tumor Characteristics ◽  
Chi Square ◽  
Population Based Study ◽  
Chi Square Test

Background: Sarcomas of the genitourinary tract are rare clinical entities with relatively few studies conducted on their prevalence and characteristics globally. Previous literature has established the effects of ethnicity and race on soft tissue sarcomas’ clinical attributes and prognosis. Objectives: To provide researchers and clinicians with a better understanding of the matter, this study aims at providing descriptive data regarding urologic sarcoma among the Iranian population. Methods: All patients diagnosed with genitourinary sarcoma registered in the Cancer Research Center (CRC) between 2009 and 2014 were enrolled in this national population-based study. Basic patient data including their gender, age, city, and province of origin, as well as each patient’s tumor characteristics were retrieved from CRC’s database. Chi-square test was utilized in determining a possible relationship between patient data and the tumor characteristics. Results: A total of 337 patients with primary genitourinary sarcoma were selected for this study. More than half of the patients were classified in the 15 to 65-year-old group. The most common primary site of involvement was the kidneys with the most prevalent histological subtype being liposarcoma. Conclusions: This study found sarcomas of the genitourinary tract to be more prevalent among the adult Iranian population, with liposarcoma, leiomyosarcoma, and rhabdomyosarcoma being the most commonly observed subtype, and factors such as age, gender, and tumor grading all related to the anatomical distribution of the tumors.

scholarly journals Characteristics of falls in elderly persons residing in the community: a population-based study

2017 ◽  
Vol 20 (5) ◽  
pp. 691-701 ◽  
Author(s):  
Suzana Albuquerque de Moraes ◽  
Wuber Jefferson Sousa Soares ◽  
Lygia Paccini Lustosa ◽  
Tereza Loffredo Bilton ◽  
Eduardo Ferrioli ◽  
...  
Keyword(s):  
The Elderly ◽  
Sociodemographic Factors ◽  
Population Based ◽  
The State ◽  
Elderly Persons ◽  
Chi Square ◽  
Cross Sectional ◽  
Population Based Study ◽  
Mato Grosso ◽  
Chi Square Test

Abstract Object: to examine the characteristics to the last fall of Brazilian elderly persons who experienced falls in 2008 and 2009, and to identify if there is a relationship with sociodemographic characteristics, physical health, comorbidities, clinical conditions and the circumstances of the falls. Methods: a cross-sectional, population based study was carried out with participants aged 65 and older from Barueri in the state of São Paulo and Cuiabá in the state of Mato Grosso, Brazil. Households were enrolled within each census region according to population density and the number of elderly persons living in each region. A multidimensional questionnaire composed of sociodemographic factors and data regarding falls was used. Associations were analyzed using contingency tables, and Fisher's Exact or Pearson's Chi-square test was used. Results: 774 elderly people were included in the study, 299 of whom reported falling in the previous year. Of these, 176 (58.9%) had fallen once and 123 (41.1%) reported having fallen twice or more. Among fallers the mean age was 72.53 (±6.12) years and 214 (71.6%) were female. About 107 (35.8%) of the elderly reported having fallen forwards, 79 (26.4%) fell to the side and 42(14%) fell backwards. Regarding the circumstances of the falls, 107 (35.8%) reported having lost their balance, 79 (26.4%) said they had stumbled and 42 (14%) said they had slipped. There was an association between the mechanism and circumstances of the falls and having fallen once or twice or more. There was an association between the circumstances of falls and the number of medications taken. Conclusion: The characteristics of falls were different among elderly persons who had fallen once or twice or more, which may guide health professionals, the elderly and their families in relation to specific fall prevention strategies.

scholarly journals Prevalence and factors associated with underweight among Brazilian older adults

2019 ◽  
Vol 24 (7) ◽  
pp. 2443-2452
Author(s):  
Priscila Maria Stolses Bergamo Francisco ◽  
Daniela de Assumpção ◽  
Flávia Silva Arbex Borim ◽  
Deborah Carvalho Malta
Keyword(s):  
Older Adults ◽  
Population Based ◽  
Northern Region ◽  
The Body ◽  
Individual Factors ◽  
Prevalence Rates ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Chi Square Test

Abstract The aim of this study was to estimate the prevalence of underweight among older adults according to socio-demographic characteristics in different regions of Brazil as well as determine associated contextual and individual factors. Cross-sectional population-based study with older adults (≥ 65 years) interviewed by telephone survey in 2014. The body mass index was calculated based on weight and height. Associations were determined using Pearson’s chi-square test, considering a 5% significance level. Adjusted prevalence ratios were estimated using multilevel Poisson regression. Mean age was 73.3 years and the prevalence of underweight was 15.6% (95%CI: 14.1-17.1%). Higher prevalence rates of underweight were found among women, individuals aged ≥ 80 years, smokers and those who reported the regular consumption of beans. The prevalence rate of underweight was lower among those who reported abusive alcohol intake and those with a medical diagnosis of hypertension. The northern region of the country had the highest prevalence of underweight after adjusting for associated individual factors. The findings demonstrate the subgroups with higher prevalence rates of underweight that demand greater attention from the health services in terms of recovering of an adequate nutritional status.

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