scholarly journals A revision of the diagnosis and affinities of the metriorhynchoids (Crocodylomorpha, Thalattosuchia) from the Rosso Ammonitico Veronese Formation (Jurassic of Italy) using specimen-level analyses

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7364 ◽  
Author(s):  
Andrea Cau
Keyword(s):  
Bayesian Inference ◽  
Bayesian Analysis ◽  
A Priori ◽  
Search Strategies ◽  
High Rate ◽  
Tree Search ◽  
The Novel ◽  
Data Set ◽  
Parsimony Tree ◽  
First Time

Neptunidraco ammoniticusis a thalattosuchian crocodylomorph from the Rosso Ammonitico Veronese Formation (RAVF, Middle Jurassic) of northern Italy. Erected from one partial specimen,Neptunidracois pivotal in reconstructing thalattosuchian evolution, being it the oldest known member of Metriorhynchidae. Two additional RAVF thalattosuchians have been referred toNeptunidraco. A revised diagnosis ofN. ammoniticusis provided here. Using a well-sampled phylogenetic data set of Crocodylomorpha, the affinities of all three RAVF thalattosuchian specimens are investigated simultaneously for the first time using parsimony tree-search strategies and Bayesian inference using the Fossilized Birth-Death with Sampled Ancestor (FBDSA) model. The results of the alternative analyses are not consistent in the placement of the RAVF specimens. The holotype ofN. ammoniticusis consequently referred to Metriorhynchidaeincertae sedis.The first referred specimen is recovered in various alternative placements among Metriorhynchoidea. The third and most fragmentary specimen is recovered as a crocodylomorph of uncertain affinities in the parsimony analysis and in the undated Bayesian analysis, and a metriorhynchoid sister taxon of the second RAVF specimen in the tip-dated Bayesian analysis. Only a subset of the results in the parsimony-based analyses supports the referral of the latter two specimens toNeptunidraco. The unusually high rate of morphological divergence for theNeptunidracobranch, inferred in previous iterations of the Bayesian inference analyses but not recovered in the novel analysis, was likely an artifact of thea prioriconstraint of all RAVF thalattosuchians into a single taxonomic unit, and of the arbitrarily fixed tip-age priors for the terminal taxa. These results confirm the utility of specimen-level morphological analysis and of combined tree-search strategies for inferring the affinities and the inclusiveness of fragmentary but significant fossil taxa, and reinforce the importance of incorporating stratigraphic uncertainty as prior in tip-dated Bayesian inference analyses.

Amphibambusa hongheensis sp. nov., a novel bambusicolous ascomycete from Yunnan, China

Phytotaxa ◽  
2021 ◽  
Vol 505 (2) ◽  
pp. 201-212
Author(s):  
HONG-BO JIANG ◽  
SHI-JIE ZHANG ◽  
RUNGTIWA PHOOKAMSAK ◽  
ITTHAYAKORN PROMPUTTHA ◽  
PATTANA KAKUMYAN ◽  
...  
Keyword(s):  
Bayesian Inference ◽  
Maximum Likelihood ◽  
Yunnan Province ◽  
Novel Species ◽  
Phylogenetic Analyses ◽  
The Novel ◽  
Molecular Approach ◽  
Mucilaginous Sheath ◽  
Phylogenetic Affinity ◽  
First Time

Amphibambusa hongheensis sp. nov. was collected from dead bamboo culms in Honghe County of Yunnan Province, China. The novel species is introduced based on the morpho-molecular approach. Morphologically, A. hongheensis fits well with Amphibambusa and is characterized by immersed, globose to subglobose ascomata, with protruding carbonaceous papilla, unitunicate, cylindrical to elongate fusiform, subsessile to short pedicellate asci with a J+, subapical ring, and fusiform, hyaline to pale brown, 1-septate ascospores, longitudinally striated, and surrounded by a thick mucilaginous sheath. Phylogenetic analyses of a concatenated ITS-LSU sequence dataset based on maximum-likelihood and Bayesian inference criteria revealed the phylogenetic affinity of A. hongheensis within Cainiaceae (Xylariales, Sordariomycetes). Amphibambusa hongheensis formed an independent subclade sister to A. bambusicola with moderate support (81% ML, 0.96 PP) and clustered with the genus Arecophila in Cainiaceae. Amphibambusa hongheensis is the second species accommodated in Amphibambusa and is reported from Yunnan, China, for the first time. Detailed description, illustration and updated phylogeny are provided.

Buried Narratives: Exhuming the Mother's Story in Oliver Twist

2018 ◽  
Vol 8 (3) ◽  
pp. 247-266
Author(s):  
Michelle L. Wilson
Keyword(s):  
Social Change ◽  
Maternal Inheritance ◽  
The Novel ◽  
Poor Law ◽  
The Family ◽  
The Law ◽  
First Time ◽  
Critical Consideration

Initially, Oliver Twist (1839) might seem representative of the archetypal male social plot, following an orphan and finding him a place by discovering the father and settling the boy within his inheritance. But Agnes Fleming haunts this narrative, undoing its neat, linear transmission. This reconsideration of maternal inheritance and plot in the novel occurs against the backdrop of legal and social change. I extend the critical consideration of the novel's relationship to the New Poor Law by thinking about its reflection on the bastardy clauses. And here, of course, is where the mother enters. Under the bastardy clauses, the responsibility for economic maintenance of bastard children was, for the first time, legally assigned to the mother, relieving the father of any and all obligation. Oliver Twist manages to critique the bastardy clauses for their release of the father, while simultaneously embracing the placement of the mother at the head of the family line. Both Oliver and the novel thus suggest that it is the mother's story that matters, her name through which we find our own. And by containing both plots – that of the father and the mother – Oliver Twist reveals the violence implicit in traditional modes of inheritance in the novel and under the law.

Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer*

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Breast Cancer ◽  
High Rate ◽  
System Level ◽  
Clinical Samples ◽  
Transcriptome Data ◽  
Data Set ◽  
Reporter Assays ◽  
Treated Breast ◽  
Mcf 7 ◽  
Resistant Cells

Quantitative phosphoproteome and transcriptome analysisof ligand-stimulated MCF-7 human breast cancer cells wasperformed to understand the mechanisms of tamoxifen resistanceat a system level. Phosphoproteome data revealed thatWT cells were more enriched with phospho-proteins thantamoxifen-resistant cells after stimulation with ligands.Surprisingly, decreased phosphorylation after ligand perturbationwas more common than increased phosphorylation.In particular, 17?-estradiol induced down-regulation inWT cells at a very high rate. 17?-Estradiol and the ErbBligand heregulin induced almost equal numbers of up-regulatedphospho-proteins in WT cells. Pathway and motifactivity analyses using transcriptome data additionallysuggested that deregulated activation of GSK3? (glycogensynthasekinase 3?) and MAPK1/3 signaling might be associatedwith altered activation of cAMP-responsive elementbindingprotein and AP-1 transcription factors intamoxifen-resistant cells, and this hypothesis was validatedby reporter assays. An examination of clinical samples revealedthat inhibitory phosphorylation of GSK3? at serine 9was significantly lower in tamoxifen-treated breast cancerpatients that eventually had relapses, implying that activationof GSK3? may be associated with the tamoxifen-resistantphenotype. Thus, the combined phosphoproteomeand transcriptome data set analyses revealed distinct signal

Application of Novel Low Current OBIRCH Amplifier and Nanoprobing to Identify Subtle Leakages in Advanced Node Technologies

2018 ◽  
Author(s):  
Satish Kodali ◽  
Liangshan Chen ◽  
Yuting Wei ◽  
Tanya Schaeffer ◽  
Chong Khiam Oh
Keyword(s):  
Signal To Noise Ratio ◽  
Semiconductor Industry ◽  
Fault Isolation ◽  
Ring Oscillator ◽  
High Signal ◽  
The Novel ◽  
Resistance Change ◽  
Three Samples ◽  
Relative Threshold ◽  
First Time

Abstract Optical beam induced resistance change (OBIRCH) is a very well-adapted technique for static fault isolation in the semiconductor industry. Novel low current OBIRCH amplifier is used to facilitate safe test condition requirements for advanced nodes. This paper shows the differences between the earlier and novel generation OBIRCH amplifiers. Ring oscillator high standby leakage samples are analyzed using the novel generation amplifier. High signal to noise ratio at applied low bias and current levels on device under test are shown on various samples. Further, a metric to demonstrate the SNR to device performance is also discussed. OBIRCH analysis is performed on all the three samples for nanoprobing of, and physical characterization on, the leakage. The resulting spots were calibrated and classified. It is noted that the calibration metric can be successfully used for the first time to estimate the relative threshold voltage of individual transistors in advanced process nodes.

Rhythmic Prose in Imperial Greek Literature

2018 ◽  
Author(s):  
G. O. Hutchinson
Keyword(s):  
The Novel ◽  
Greek Literature ◽  
System A ◽  
First Time

The chapter looks at the division between poetry and prose in ancient and other literatures, and shows the importance of rhythmic patterning in ancient prose. The development of rhythmic prose in Greek and Latin is sketched, the system explained and illustrated (from Latin). It is firmly established, for the first time, which of the main Greek non-Christian authors 31 BC–AD 300 write rhythmically. The method takes a substantial sample of random sentence-endings (usually 400) from each of a large number of Imperial authors; it compares that sample with one sample of the same size (400) drawn randomly from a range of authors earlier than the invention of this rhythmic system. A particular sort of X2-test is applied. Many Imperial authors, it emerges, write rhythmically; many do not. The genres most likely to offer rhythmic writing are, unexpectedly, narrative: historiography and the novel.

Kidnapped

2014 ◽  
Author(s):  
Robert Louis Stevenson ◽  
Ian Duncan
Keyword(s):  
West Coast ◽  
Historical Novel ◽  
The Novel ◽  
The West ◽  
Scottish Highlands ◽  
Cross Country ◽  
First Time ◽  
Adventure Stories

Your bed shall be the moorcock’s, and your life shall be like the hunted deer’s, and ye shall sleep with your hand upon your weapons.’ Tricked out of his inheritance, shanghaied, shipwrecked off the west coast of Scotland, David Balfour finds himself fleeing for his life in the dangerous company of Jacobite outlaw and suspected assassin Alan Breck Stewart. Their unlikely friendship is put to the test as they dodge government troops across the Scottish Highlands. Set in the aftermath of the 1745 rebellion, Kidnapped transforms the Romantic historical novel into the modern thriller. Its heart-stopping scenes of cross-country pursuit, distilled to a pure intensity in Stevenson’s prose, have become a staple of adventure stories from John Buchan to Alfred Hitchcock and Ian Fleming. Kidnapped remains as exhilarating today as when it was first published in 1886. This new edition is based on the 1895 text, incorporating Stevenson’s last thoughts about the novel before his death. It includes Stevenson’s ‘Note to Kidnapped’, reprinted for the first time since 1922.

Intuitionistic fuzzy two-factor variance analysis of movie ticket sales

2021 ◽  
pp. 1-11
Author(s):  
Velichka Traneva ◽  
Stoyan Tranev
Keyword(s):  
Comparative Analysis ◽  
Real Data ◽  
Intuitionistic Fuzzy Sets ◽  
Real Numbers ◽  
Data Set ◽  
Important Method ◽  
Ticket Sales ◽  
Intuitionistic Fuzzy ◽  
The One ◽  
First Time

Analysis of variance (ANOVA) is an important method in data analysis, which was developed by Fisher. There are situations when there is impreciseness in data In order to analyze such data, the aim of this paper is to introduce for the first time an intuitionistic fuzzy two-factor ANOVA (2-D IFANOVA) without replication as an extension of the classical ANOVA and the one-way IFANOVA for a case where the data are intuitionistic fuzzy rather than real numbers. The proposed approach employs the apparatus of intuitionistic fuzzy sets (IFSs) and index matrices (IMs). The paper also analyzes a unique set of data on daily ticket sales for a year in a multiplex of Cinema City Bulgaria, part of Cineworld PLC Group, applying the two-factor ANOVA and the proposed 2-D IFANOVA to study the influence of “ season ” and “ ticket price ” factors. A comparative analysis of the results, obtained after the application of ANOVA and 2-D IFANOVA over the real data set, is also presented.

scholarly journals A Traveler’s Guide to the Multiverse: Promises, Pitfalls, and a Framework for the Evaluation of Analytic Decisions

2021 ◽  
Vol 4 (1) ◽  
pp. 251524592095492
Author(s):  
Marco Del Giudice ◽  
Steven W. Gangestad
Keyword(s):  
Degrees Of Freedom ◽  
A Priori ◽  
Simulated Data ◽  
Style Analysis ◽  
Data Set ◽  
Scant Attention ◽  
Equivalence Type ◽  
The Impact ◽  
Biased Estimates

Decisions made by researchers while analyzing data (e.g., how to measure variables, how to handle outliers) are sometimes arbitrary, without an objective justification for choosing one alternative over another. Multiverse-style methods (e.g., specification curve, vibration of effects) estimate an effect across an entire set of possible specifications to expose the impact of hidden degrees of freedom and/or obtain robust, less biased estimates of the effect of interest. However, if specifications are not truly arbitrary, multiverse-style analyses can produce misleading results, potentially hiding meaningful effects within a mass of poorly justified alternatives. So far, a key question has received scant attention: How does one decide whether alternatives are arbitrary? We offer a framework and conceptual tools for doing so. We discuss three kinds of a priori nonequivalence among alternatives—measurement nonequivalence, effect nonequivalence, and power/precision nonequivalence. The criteria we review lead to three decision scenarios: Type E decisions (principled equivalence), Type N decisions (principled nonequivalence), and Type U decisions (uncertainty). In uncertain scenarios, multiverse-style analysis should be conducted in a deliberately exploratory fashion. The framework is discussed with reference to published examples and illustrated with the help of a simulated data set. Our framework will help researchers reap the benefits of multiverse-style methods while avoiding their pitfalls.

scholarly journals Candida auris: A Quick Review on Identification, Current Treatments, and Challenges

2021 ◽  
Vol 22 (9) ◽  
pp. 4470
Author(s):  
Lucia Černáková ◽  
Maryam Roudbary ◽  
Susana Brás ◽  
Silva Tafaj ◽  
Célia F. Rodrigues
Keyword(s):  
Multidrug Resistance ◽  
Alternative Treatment ◽  
Fungal Pathogen ◽  
Fungal Diseases ◽  
High Rate ◽  
The Novel ◽  
Mechanisms Of Resistance ◽  
Candida Auris ◽  
Natural And Synthetic

Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported.

scholarly journals Hyperbolic Wavelet Analysis of Classical Isotropic and Anisotropic Besov–Sobolev Spaces

2021 ◽  
Vol 27 (3) ◽  
Author(s):  
Martin Schäfer ◽  
Tino Ullrich ◽  
Béatrice Vedel
Keyword(s):  
Haar System ◽  
A Priori ◽  
Natural Setting ◽  
The Novel ◽  
Major Question ◽  
Vanishing Moments ◽  
Classical Setting ◽  
Hyperbolic Wavelets ◽  
The Relationship ◽  
Mixed Smoothness

AbstractIn this paper we introduce new function spaces which we call anisotropic hyperbolic Besov and Triebel-Lizorkin spaces. Their definition is based on a hyperbolic Littlewood-Paley analysis involving an anisotropy vector only occurring in the smoothness weights. Such spaces provide a general and natural setting in order to understand what kind of anisotropic smoothness can be described using hyperbolic wavelets (in the literature also sometimes called tensor-product wavelets), a wavelet class which hitherto has been mainly used to characterize spaces of dominating mixed smoothness. A centerpiece of our present work are characterizations of these new spaces based on the hyperbolic wavelet transform. Hereby we treat both, the standard approach using wavelet systems equipped with sufficient smoothness, decay, and vanishing moments, but also the very simple and basic hyperbolic Haar system. The second major question we pursue is the relationship between the novel hyperbolic spaces and the classical anisotropic Besov–Lizorkin-Triebel scales. As our results show, in general, both approaches to resolve an anisotropy do not coincide. However, in the Sobolev range this is the case, providing a link to apply the newly obtained hyperbolic wavelet characterizations to the classical setting. In particular, this allows for detecting classical anisotropies via the coefficients of a universal hyperbolic wavelet basis, without the need of adaption of the basis or a-priori knowledge on the anisotropy.

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