scholarly journals The association between elevated serum uric acid levels and islet β-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4515 ◽  
Author(s):  
Yimeng Hu ◽  
Jie Liu ◽  
Huiqiong Li ◽  
Hui Zhu ◽  
Linjie Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Secretion ◽  
Serum Lipids ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Islet Function ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional

Background Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association, both remain undefined. Methods A cross-sectional study was designed and performed, which enrolled a total of 403 newly diagnosed T2DM patients (mean age, 50.21 ± 13.34 years (62.5% males)). Clinical characteristics and islet function indexes of all participants were analyzed based on gender-specific tertiles of serum UA levels. In addition, multiple linear regression analysis was conducted to investigate covariates associated with islet function indexes. Results The mean levels of serum UA were 331.05 μmol/L (interquartile range (IQR): 60.6, 400.9 μmol/L) and 267.9 μmol/L (IQR: 204.7, 331.9 μmol/L) in men and women, respectively. The values of insulin secretion indexes involving AUCins30/glu30, AUCins120/glu120 and total insulin disposition index (DI120) in females were significantly higher than those in males. Apart from the homeostasis model assessment insulin resistance of men, serum UA was positively associated with insulin secretion and insulin resistance indexes both in men and women. Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. In males, islet function was simultaneously affected by serum UA age, body mass index (BMI), and serum lipids. Conclusion Serum UA harbored a positive correlation with insulin secretion and insulin resistance indexes in newly diagnosed T2DM patients, which was influenced by gender, BMI, serum lipids. Hence, serum UA may be considered as a predictor for islet function in clinical practice.

scholarly journals Serum magnesium and visfatin levels in newly diagnosed non-obese type 2 diabetes without insulin resistance: a cross-sectional study

2021 ◽  
Vol 10 (1) ◽  
pp. 123-128
Author(s):  
Shatha R. ‎Moustafa ‎ ◽  
Iman M. Jebur ◽  
‎Muntadher A. Hasan ◽  
Marwan S.M. Al-Nimer
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Serum Magnesium ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional

The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study

2012 ◽  
Vol 50 (3) ◽  
pp. 429-436 ◽  
Author(s):  
Anna Rita Bonfigli ◽  
Cristina Sirolla ◽  
Roberto Testa ◽  
Michela Cucchi ◽  
Liana Spazzafumo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
P53 Codon 72 ◽  
Cross Sectional ◽  
Codon 72 ◽  
Type 2 Diabetic

scholarly journals Lipid profile abnormalities in newly diagnosed type 2 diabetics: a cross-sectional study

2019 ◽  
Vol 6 (5) ◽  
pp. 1452
Author(s):  
Monica A. ◽  
Dhivya P.
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Cross Sectional Study ◽  
South Indian Population ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type 2 Diabetics ◽  
Very High

Background: India is fast becoming the diabetes capital of the World. A direct atherogenic effect of triglyceride rich particles has been noted. This study assesses the lipid profile abnormalities in newly diagnosed type 2 diabetes mellitus. Since dyslipidemia is a risk factor for cardiovascular disease, such assessment will enable better recognition, prevention and management of cardiovascular mortality and morbidity.Methods: The study was conducted over a period of one year at a tertiary care hospital in South India. A cross-sectional study of 100 newly diagnosed type 2 diabetics in a rural South-Indian population was done. Results: In our study, 55 (55%) participants had high triglycerides and 45 (45%) had normal triglycerides.  Among the 55 participants with abnormal triglycerides, 34% had borderline high levels (150-199mg/dl), 18% had high levels (200-499 mg/dl) and 3% participants had very high triglycerides (≥500 mg/dl). 26% male and 29% female participants had above normal triglyceride levels. In our study, 25% had borderline high cholesterol levels and 5% had high total Cholesterol. 39% of participants had near optimal levels of LDL, 19% had borderline high levels of LDL, 7% had high levels of LDL and 4% had very high levels of LDL. Significantly higher levels of triglycerides and LDL were noted.Conclusions: Deranged lipid profiles are quite prevalent in type 2 diabetics with females having higher triglyceride levels. Recognition of such elevated triglyceride levels in even newly diagnosed type 2 diabetics will help in better prevention of associated cardiovascular disease.

scholarly journals Association between thyroid hormones and diabetic complications in patients with newly diagnosed type 2 diabetes: A cross-sectional study

2021 ◽  
Author(s):  
Yanli Li ◽  
Min Yi ◽  
Xiaoyi Deng ◽  
Wangen Li ◽  
Yimei Chen ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Diabetic Complications ◽  
Demographic Factors ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Free T4 ◽  
Cross Sectional ◽  
Low T3

Abstract Background Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The coexistence of TD could adversely influence metabolic control and even increase the long-term mortality in patients with DM. The objective of the present study was to investigate the thyroid status and the relationship between thyroid hormones, diabetic complications and metabolic parameters in patients with newly diagnosed type 2 DM (T2DM). Methods This is an observational cross-sectional study, conducting on 340 patients with newly diagnosed T2DM who were admitted to ward of endocrinology department and 120 matched nondiabetic subjects. Clinical characteristics were collected and laboratory measurements were conducted. Results Levels of free T3 (FT3), free T4 (FT4) and TSH were significantly lower in patients with T2DM as compared to nondiabetic subjects. The prevalence of TD was 21.2% in patients with diabetes, higher than that of controls (4.2%). The low T3 syndrome was the most frequent TD, shown in 14.7% of patients. The presence of diabetic complications (diabetic nephropathy (DN), diabetic ketosis), metabolic and demographic factors, including age, glycemic control and insulin resistance were factors associated with levels of thyroid hormones. FT3 level was inversely correlated with the level of urinary total protein (mg/24h) and the presence of DN. Multivariate analysis indicated low FT3 level as a strong independent risk factor (OR = 0.364, P < 0.001) for DN. Conclusions TD is not rarely seen in patients with newly diagnosed T2DM. Diabetic complications and diabetes-related metabolic and demographic factors are related to TD. Decreased FT3 is strongly correlated with the presence of DN.

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