scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

PeerJ ◽  
2014 ◽  
Vol 2 ◽  
pp. e392 ◽  
Author(s):  
Larry J. Leamy ◽  
Kari Elo ◽  
Merlyn K. Nielsen ◽  
Stephanie R. Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Advanced Intercross Line ◽  
Trait Loci

scholarly journals Identification of Quantitative Trait Loci Influencing Traits Related to Energy Balance in Selection and Inbred Lines of Mice

Genetics ◽  
1999 ◽  
Vol 152 (2) ◽  
pp. 699-711 ◽  
Author(s):  
D E Moody ◽  
D Pomp ◽  
M K Nielsen ◽  
L D Van Vleck
Keyword(s):  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Subcutaneous Fat ◽  
High Heat ◽  
Chromosome 1 ◽  
Direct Calorimetry ◽  
Resource Population ◽  
Trait Loci

Abstract Energy balance is a complex trait with relevance to the study of human obesity and maintenance energy requirements of livestock. The objective of this study was to identify, using unique mouse models, quantitative trait loci (QTL) influencing traits that contribute to variation in energy balance. Two F2 resource populations were created from lines of mice differing in heat loss measured by direct calorimetry as an indicator of energy expenditure. The HB F2 resource population originated from a cross between a noninbred line selected for high heat loss and an inbred line with low heat loss. Evidence for significant QTL influencing heat loss was found on chromosomes 1, 2, 3, and 7. Significant QTL influencing body weight and percentage gonadal fat, brown fat, liver, and heart were also identified. The LH F2 resource population originated from noninbred lines of mice that had undergone divergent selection for heat loss. Chromosomes 1 and 3 were evaluated. The QTL for heat loss identified on chromosome 1 in the HB population was confirmed in the LH population, although the effect was smaller. The presence of a QTL influencing 6-wk weight was also confirmed. Suggestive evidence for additional QTL influencing heat loss, percentage subcutaneous fat, and percentage heart was found for chromosome 1.

scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

2014 ◽  
Author(s):  
Larry Leamy ◽  
Kari Elo ◽  
Merlyn K Nielsen ◽  
Stephanie Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Parameter Analysis ◽  
Chromosome 1 ◽  
Health Concern ◽  
Trait Loci

Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate the genetic basis of a number of energy balance traits in an F11 advanced intercross population of mice created from an original intercross of lines selected for increased and decreased heat loss. We uncovered a total of 137 quantitative trait loci (QTLs) for these traits at 41 unique sites on 18 of the 20 chromosomes in the mouse genome, with X-linked QTLs being most prevalent. Two QTLs were found for the selection target of heat loss, one on distal chromosome 1 and another on proximal chromosome 2. The number of QTLs affecting the various traits generally was consistent with previous estimates of heritabilities in the same population, with the most found for two bone mineral traits and the least for feed intake and several body composition traits. QTLs were generally additive in their effects, and some, especially those affecting the body weight traits, were sex-specific. Pleiotropy was extensive within trait groups (body weights, adiposity and organ weight traits, bone traits) and especially between body composition traits adjusted and not adjusted for body weight at sacrifice. Nine QTLs were found for one or more of the adiposity traits, five of which appeared to be unique. The confidence intervals among all QTLs averaged 13.3 Mb, much smaller than usually observed in an F2 cross, and in some cases this allowed us to make reasonable inferences about candidate genes underlying these QTLs. This study combined QTL mapping with genetic parameter analysis in a large segregating population, and has advanced our understanding of the genetic architecture of complex traits related to obesity.

scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

2014 ◽  
Author(s):  
Larry Leamy ◽  
Kari Elo ◽  
Merlyn K Nielsen ◽  
Stephanie Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Parameter Analysis ◽  
Chromosome 1 ◽  
Health Concern ◽  
Trait Loci

Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate the genetic basis of a number of energy balance traits in an F11 advanced intercross population of mice created from an original intercross of lines selected for increased and decreased heat loss. We uncovered a total of 137 quantitative trait loci (QTLs) for these traits at 41 unique sites on 18 of the 20 chromosomes in the mouse genome, with X-linked QTLs being most prevalent. Two QTLs were found for the selection target of heat loss, one on distal chromosome 1 and another on proximal chromosome 2. The number of QTLs affecting the various traits generally was consistent with previous estimates of heritabilities in the same population, with the most found for two bone mineral traits and the least for feed intake and several body composition traits. QTLs were generally additive in their effects, and some, especially those affecting the body weight traits, were sex-specific. Pleiotropy was extensive within trait groups (body weights, adiposity and organ weight traits, bone traits) and especially between body composition traits adjusted and not adjusted for body weight at sacrifice. Nine QTLs were found for one or more of the adiposity traits, five of which appeared to be unique. The confidence intervals among all QTLs averaged 13.3 Mb, much smaller than usually observed in an F2 cross, and in some cases this allowed us to make reasonable inferences about candidate genes underlying these QTLs. This study combined QTL mapping with genetic parameter analysis in a large segregating population, and has advanced our understanding of the genetic architecture of complex traits related to obesity.

scholarly journals Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line

Heredity ◽  
2014 ◽  
Vol 112 (5) ◽  
pp. 508-518 ◽  
Author(s):  
J M Cheverud ◽  
H A Lawson ◽  
K Bouckaert ◽  
A V Kossenkov ◽  
L C Showe ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Tissue Regeneration ◽  
Fine Mapping ◽  
Quantitative Trait ◽  
External Ear ◽  
Advanced Intercross Line ◽  
Trait Loci

scholarly journals Quantitative trait loci identified for blood chemistry components of an advanced intercross line of chickens under heat stress

BMC Genomics ◽  
2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Angelica Van Goor ◽  
Christopher M. Ashwell ◽  
Michael E. Persia ◽  
Max F. Rothschild ◽  
Carl J. Schmidt ◽  
...  
Keyword(s):  
Heat Stress ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Blood Chemistry ◽  
Advanced Intercross Line ◽  
Trait Loci

scholarly journals Fine Mapping of Collagen-Induced Arthritis Quantitative Trait Loci in an Advanced Intercross Line

2006 ◽  
Vol 177 (10) ◽  
pp. 7042-7049 ◽  
Author(s):  
Xinhua Yu ◽  
Kristin Bauer ◽  
Patrik Wernhoff ◽  
Dirk Koczan ◽  
Steffen Möller ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Fine Mapping ◽  
Quantitative Trait ◽  
Collagen Induced Arthritis ◽  
Advanced Intercross Line ◽  
Trait Loci
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