scholarly journals ProbioticBacillus coagulansGBI-30, 6086 reduces exercise-induced muscle damage and increases recovery

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2276 ◽  
Author(s):  
Ralf Jäger ◽  
Kevin A. Shields ◽  
Ryan P. Lowery ◽  
Eduardo O. De Souza ◽  
Jeremy M. Partl ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Athletic Performance ◽  
Vertical Jump ◽  
Bacillus Coagulans ◽  
Exercise Bout ◽  
Strenuous Exercise ◽  
Post Exercise ◽  
Nitrogen Levels ◽  
And Performance ◽  
Exercise Induced

Objective.Probiotics have been reported to support healthy digestive and immune function, aid in protein absorption, and decrease inflammation. Further, a trend to increase vertical jump power has been observed following co-administration of protein and probiotics in resistance-trained subjects. However, to date the potential beneficial effect of probiotics on recovery from high intensity resistance exercise have yet to be explored. Therefore, this study examined the effect of co-administration of protein and probiotics on muscle damage, recovery and performance following a damaging exercise bout.Design.Twenty nine (n= 29) recreationally-trained males (mean ± SD; 21.5 ± 2.8 years; 89.7 ± 28.2 kg; 177.4 ± 8.0 cm) were assigned to consume either 20 g of casein (PRO) or 20 g of casein plus probiotic (1 billion CFUBacillus coagulansGBI-30, 6086, PROBC) in a crossover, diet-controlled design. After two weeks of supplementation, perceptional measures, athletic performance, and muscle damage were analyzed following a damaging exercise bout.Results.The damaging exercise bout significantly increased muscle soreness, and reduced perceived recovery; however, PROBC significantly increased recovery at 24 and 72 h, and decreased soreness at 72 h post exercise in comparison to PRO. Perceptual measures were confirmed by increases in CK (PRO: +266.8%,p= 0.0002; PROBC: +137.7%,p= 0.01), with PROBC showing a trend towards reduced muscle damage (p= 0.08). The muscle-damaging exercise resulted in significantly increased muscle swelling and Blood Urea Nitrogen levels in both conditions with no difference between groups. The strenuous exercise significantly reduced athletic performance in PRO (Wingate Peak Power; PRO: (−39.8 watts, −5.3%,p= 0.03)), whereas PROBC maintained performance (+10.1 watts, +1.7%).Conclusions.The results provide evidence that probiotic supplementation in combination with protein tended to reduce indices of muscle damage, improves recovery, and maintains physical performance subsequent to damaging exercise.

scholarly journals The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis

2021 ◽  
pp. 1-11
Author(s):  
Kenji Doma ◽  
Utkarsh Singh ◽  
Daniel Boullosa ◽  
Jonathan Douglas Connor
Keyword(s):  
Systematic Review ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Meta Analysis ◽  
Muscle Performance ◽  
Strenuous Exercise ◽  
Post Exercise ◽  
Branched Chain ◽  
And Performance ◽  
Muscle Damage Markers

This systematic review and meta-analysis determined whether the ergogenic effects of branched-chain amino acids (BCAA) ameliorated markers of muscle damage and performance following strenuous exercise. In total, 25 studies were included, consisting of 479 participants (age 24.3 ± 8.3 years, height 1.73 ± 0.06 m, body mass 70.8 ± 9.5 kg, females 26.3%). These studies were rated as fair to excellent following the PEDro scale. The outcome measures were compared between the BCAA and placebo conditions at 24 and 48 hours following muscle-damaging exercises, using standardised mean differences and associated p-values via forest plots. Our meta-analysis demonstrated significantly lower levels of indirect muscle damage markers (creatine kinase, lactate dehydrogenase and myoglobin) at 48 hours post-exercise (standardised mean difference [SMD] = −0.41; p < 0.05) for the BCAA than placebo conditions, whilst muscle soreness was significant at 24 hours post-exercise (SMD = −0.28 ≤ d ≤ −0.61; p < 0.05) and 48 hours post-exercise (SMD = −0.41 ≤ d≤ −0.92; p < 0.01). However, no significant differences were identified between the BCAA and placebo conditions for muscle performance at 24 or 48 hours post-exercise (SMD = 0.08 ≤ d ≤ 0.21; p > 0.05). Overall, BCAA reduced the level of muscle damage biomarkers and muscle soreness following muscle-damaging exercises. However, the potential benefits of BCAA for muscle performance recovery is questionable and warrants further investigation to determine the practicality of BCAA for ameliorating muscle damage symptoms in diverse populations. PROSPERO registration number: CRD42020191248. Novelty: BCAA reduces the level of creatine kinase and muscle soreness following strenuous exercise with a dose–response relationship. BCAA does not accelerate recovery for muscle performance.

CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage

2010 ◽  
Vol 108 (6) ◽  
pp. 1651-1658 ◽  
Author(s):  
Monica J. Hubal ◽  
Joseph M. Devaney ◽  
Eric P. Hoffman ◽  
Edward J. Zambraski ◽  
Heather Gordish-Dressman ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Exercise Bout ◽  
Large Degree ◽  
Strength Loss ◽  
Strenuous Exercise ◽  
Nucleotide Polymorphisms ◽  
Strength Recovery ◽  
Damage Response ◽  
Exercise Induced

Novel eccentric (lengthening contraction) exercise typically results in muscle damage, which manifests as prolonged muscle dysfunction, delayed onset muscle soreness, and leakage of muscle proteins into circulation. There is a large degree of variability in the damage response of individuals to eccentric exercise, with higher responders at risk for potentially fatal rhabdomyolysis. We hypothesized that single nucleotide polymorphisms (SNPs) in chemokine ligand 2 ( CCL2) and its receptor chemokine receptor 2 ( CCR2) associate with the high degrees of variability in the muscle damage response. We based this hypothesis on CCL2's roles in macrophage and satellite cell signaling in injured muscle. DNA was obtained from 157 untrained men and women following maximal eccentric exercise. Strength loss, soreness, serum creatine kinase (CK), and myoglobin levels before and during recovery from a single exercise bout were tested for association with 16 SNPs in CCL2 and CCR2. The rare alleles for rs768539 and rs3918358 (CCR2) were significantly ( P < 0.05) associated with lower preexercise strength in men, whereas CCL2 SNPs (rs13900, rs1024611, and rs1860189) and CCR2 (rs1799865) were associated with altered preexercise CK levels in women. During recovery, the rs3917878 genotype ( CCL2) was associated with attenuated strength recovery in men and an elevated CK response in women. CCR2 variants were associated with slower strength recovery in women (rs3918358) and elevated soreness (rs1799865) across all subjects. In summary, we found that SNPs in CCL2 and CCR2 are associated with exercise-induced muscle damage and that the presence of certain variants may result in an exaggerated damage response to strenuous exercise.

scholarly journals Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women

2009 ◽  
Vol 107 (3) ◽  
pp. 853-858 ◽  
Author(s):  
Christina M. Dieli-Conwright ◽  
Tanya M. Spektor ◽  
Judd C. Rice ◽  
E. Todd Schroeder
Keyword(s):  
Skeletal Muscle ◽  
Hormone Therapy ◽  
Mrna Expression ◽  
Postmenopausal Women ◽  
Muscle Damage ◽  
Exercise Bout ◽  
Control Group ◽  
Skeletal Muscle Damage ◽  
Tnf Α ◽  
Exercise Induced

Hormone therapy (HT) is a potential treatment to relieve symptoms of menopause and prevent the onset of disease such as osteoporosis in postmenopausal women. We evaluated changes in markers of exercise-induced skeletal muscle damage and inflammation [serum creatine kinase (CK), serum lactate dehydrogenase (LDH), and skeletal muscle mRNA expression of IL-6, IL-8, IL-15, and TNF-α] in postmenopausal women after a high-intensity resistance exercise bout. Fourteen postmenopausal women were divided into two groups: women not using HT (control; n = 6, 59 ± 4 yr, 63 ± 17 kg) and women using traditional HT (HT; n = 8, 59 ± 4 yr, 89 ± 24 kg). Both groups performed 10 sets of 10 maximal eccentric repetitions of single-leg extension on the Cybex dynamometer at 60°/s with 20-s rest periods between sets. Muscle biopsies of the vastus lateralis were obtained from the exercised leg at baseline and 4 h after the exercise bout. Gene expression was determined by RT-PCR for IL-6, IL-8, IL-15, and TNF-α. Blood draws were performed at baseline and 3 days after exercise to measure CK and LDH. Independent t-tests were performed to test group differences (control vs. HT). A probability level of P ≤ 0.05 was used to determine statistical significance. We observed significantly greater changes in mRNA expression of IL-6, IL-8, IL-15, and TNF-α ( P ≤ 0.01) in the control group compared with the HT group after the exercise bout. CK and LDH levels were significantly greater after exercise ( P ≤ 0.01) in the control group. Postmenopausal women not using HT experienced greater muscle damage after maximal eccentric exercise, indicating a possible protective effect of HT against exercise-induced skeletal muscle damage.

scholarly journals Post-Exercise Recovery Following 30-Day Supplementation of Trans-Resveratrol and Polyphenol-Enriched Extracts

Sports ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 226 ◽  
Author(s):  
Edward Jo ◽  
Rachel Bartosh ◽  
Alexandra T. Auslander ◽  
Dean Directo ◽  
Adam Osmond ◽  
...  
Keyword(s):  
Pain Threshold ◽  
Vastus Lateralis ◽  
Pain Tolerance ◽  
Placebo Control ◽  
Post Exercise ◽  
Reactive Protein ◽  
Vastus Intermedius ◽  
And Performance ◽  
Exercise Induced ◽  
Post Exercise Recovery

Background: The purpose of this study was to investigate the effects of 30-day consumption of trans-resveratrol and polyphenol-enriched extracts on indices of exercise-induced muscle damage (EIMD) and performance following eccentric-loaded resistance exercise (ECRE). Methods: Following 30 days of resveratrol-polyphenol (RES) (n = 10) or placebo control (CTL) (n = 12) supplementation, subjects performed a bout of ECRE to induce EIMD. EIMD biomarkers, perceived soreness, pain threshold and tolerance, range of motion, and performance were measured before and 24 and 48 h after ECRE. Results: CTL subjects demonstrated increased soreness at 24 (p = 0.02) and 48 h (p = 0.03) post-ECRE, while RES subjects reported increased soreness at 24 h post-ECRE (p = 0.0003). CTL subjects exhibited decreased pain threshold in the vastus lateralis at 24 h post-ECRE (p = 0.03). CTL subjects also displayed decreased pain tolerance in the vastus intermedius at 24 h post-ECRE (p = 0.03) and the vastus lateralis at 24 (p = 0.003) and 48 h (p = 0.003). RES participants showed no change in pain threshold or tolerance from baseline. CTL subjects showed a decrease in mean (p = 0.04) and peak power (p = 0.04) at 24 h post-ECRE, while RES participants demonstrated no changes from baseline. No between-group differences were observed for the changes in serum creatine kinase. Serum C-reactive protein increased similarly in both groups at 24 h post-ECRE (p < 0.002), remaining elevated in CTL subjects while RES participants demonstrated a decline from 24 to 48 h (p = 0.04). Serum interleukin 6 increased at 24 h post-ECRE in both groups (p < 0.003) followed by a decrease from 24 to 48 h, returning to baseline levels only for RES subjects. Conclusion: Trans-resveratrol and polyphenol-enriched extract supplementation may support the attenuation of soreness and inflammation and improve performance recovery following ECRE without modulation of indirect biomarkers of EIMD.

scholarly journals Cryotherapy Models and Timing-Sequence Recovery of Exercise-Induced Muscle Damage in Middle- and Long-Distance Runners

2020 ◽  
Vol 55 (4) ◽  
pp. 329-335
Author(s):  
Chaoyi Qu ◽  
Zhaozhao Wu ◽  
Minxiao Xu ◽  
Fei Qin ◽  
Yanan Dong ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Cold Water ◽  
Water Immersion ◽  
Whole Body ◽  
Strenuous Exercise ◽  
Distance Runners ◽  
Long Distance ◽  
Positive Effects ◽  
Exercise Induced ◽  
Recovery Methods

Context Among sports-recovery methods, cold-water immersion (CWI), contrast-water therapy (CWT), and whole-body cryotherapy (WBC) have been applied widely to enhance recovery after strenuous exercise. However, the different timing effects in exercise-induced muscle damage (EIMD) after these recovery protocols remain unknown. Objective To compare the effects of CWI, CWT, and WBC on the timing-sequence recovery of EIMD through different indicator responses. Design Crossover study. Setting Laboratory. Patients or Other Participants Twelve male middle- and long-distance runners from the Beijing Sport University (age = 21.00 ± 0.95 years). Intervention(s) Participants were treated with different recovery methods (control [CON], CWI, CWT, WBC) immediately postexercise and at 24, 48, and 72 hours postexercise. Main Outcome Measure(s) We measured perceived sensation using a visual analog scale (VAS), plasma creatine kinase (CK) activity, plasma C-reactive protein (CRP) activity, and vertical-jump height (VJH) pre-exercise, immediately postexercise, and at 1, 24, 48, 72, and 96 hours postexercise. Results For the VAS score and CK activity, WBC exhibited better timing-sequence recovery effects than CON and CWI (P &lt; .05), but the CWT demonstrated better effects than CON (P &lt; .05). The CRP activity was lower after WBC than after the other interventions (P &lt; .05). The VJH was lower after WBC than after CON and CWI (P &lt; .05). Conclusions The WBC positively affected VAS, CK, CRP, and VJH associated with EIMD. The CWT and CWI also showed positive effects. However, for the activity and timing-sequence effect, CWT had weaker effects than WBC.

scholarly journals Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 372 ◽  
Author(s):  
María Martinez-Ferran ◽  
Fabian Sanchis-Gomar ◽  
Carl J. Lavie ◽  
Giuseppe Lippi ◽  
Helios Pareja-Galeano
Keyword(s):  
Systematic Review ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Web Of Science ◽  
Exercise Session ◽  
Post Exercise ◽  
High Doses ◽  
Exercise Induced ◽  
Cell Signaling Pathways

Free radicals produced during exercise play a role in modulating cell signaling pathways. High doses of antioxidants may hamper adaptations to exercise training. However, their benefits are unclear. This review aims to examine whether vitamin C (VitC) and/or vitamin E (VitE) supplementation (SUP) prevents exercise-induced muscle damage. The PubMed, Web of Science, Medline, CINAHL, and SPORTDiscus databases were searched, and 21 articles were included. Four studies examined the effects of acute VitC SUP given pre-exercise: in one study, lower CK levels post-exercise was observed; in three, no difference was recorded. In one study, acute VitE SUP reduced CK activity 1 h post-exercise in conditions of hypoxia. In three studies, chronic VitE SUP did not reduce CK activity after an exercise session. Chronic VitE SUP did not reduce creatine kinase (CK) concentrations after three strength training sessions, but it was effective after 6 days of endurance training in another study. Chronic SUP with VitC + E reduced CK activity post-exercise in two studies, but there was no such effect in four studies. Finally, three studies described the effects of chronic VitC + E SUP and long-term exercise, reporting dissimilar results. To conclude, although there is some evidence of a protective effect of VitC and/or VitE against exercise-induced muscle damage, the available data are not conclusive.

Effects of oral l-carnitine supplementation in racing Greyhounds

2007 ◽  
Vol 4 (3-4) ◽  
pp. 141-147 ◽  
Author(s):  
T S Epp ◽  
H H Erickson ◽  
J Woodworth ◽  
D C Poole
Keyword(s):  
Muscle Damage ◽  
Creatine Phosphokinase ◽  
The Novel ◽  
Carnitine Supplementation ◽  
Plasma Lactate ◽  
Post Exercise ◽  
Maximal Speed ◽  
Exercise Muscle ◽  
Exercise Induced ◽  
Very High

Abstractl-Carnitine supplementation can stimulate erythropoiesis, reduce exercise-induced plasma lactate concentrations and decrease post-exercise muscle damage. Next to horses, Greyhounds represent the premier animal racing species and perform short-duration, very high-intensity exercise that has the potential to incur substantial muscle damage. Under resting and standard racing conditions (5/16 mile), we tested the novel hypotheses that l-carnitine supplementation in Greyhounds would: (1) elevate haematocrit at rest and immediately post-exercise; (2) reduce peak post-exercise plasma lactate; and (3) reduce indices of muscle damage (plasma creatine phosphokinase, CPK and aspartate aminotransferase, AST). Six conditioned Greyhounds (30.1 ± 1.6 kg) underwent a randomized placebo-controlled crossover study to determine the effects of 6 weeks of l-carnitine supplementation (100 mg kg− 1 of body weight/day) at rest and following a maximal speed 5/16 mile race. In accordance with our hypotheses, l-carnitine elevated resting and immediately post-race haematocrit (control, 60.1 ± 1.7, l-carnitine, 63.6 ± 1.7; P < 0.05) and reduced peak post-race plasma CPK and AST concentrations (both P < 0.05). Those dogs with the highest peak post-exercise plasma CPK concentrations under placebo conditions evidenced the greatest reduction with l-carnitine supplementation (r = 0.99, P < 0.01). However, contrary to our hypotheses, l-carnitine did not change peak post-exercise plasma lactate concentrations (control, 27.0 ± 2.1, l-carnitine, 27.7 ± 1.3; P>0.05). We conclude that l-carnitine supplementation increases the potential for oxygen transport and reduces plasma indicators of muscle damage, CPK and AST in racing Greyhounds.

Short-Term β-Hydroxy-β-Methylbutyrate Supplementation Does Not Reduce Symptoms of Eccentric Muscle Damage

2001 ◽  
Vol 11 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Douglas Paddon-Jones ◽  
Andrew Keech ◽  
David Jenkins
Keyword(s):  
Body Weight ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Exercise Bout ◽  
Similar Amount ◽  
Short Term ◽  
Placebo Condition ◽  
Post Exercise ◽  
Eccentric Muscle Damage

Purpose:We examined the effects of short-term β-hydroxy-β-methylbutyrate (HMB) supplementation on symptoms of muscle damage following an acute bout of eccentric exercise.Methods:Non-resistance trained subjects were randomly assigned to a HMB supplement group (HMB, 40mg/kg body weight/day, n = 8) or placebo group (CON, n = 9). Supplementation commenced 6 days prior to a bout of 24 maximal isokinetic eccentric contractions of the elbow flexors and continued throughout post-testing. Muscle soreness, upper arm girth, and torque measures were assessed pre-exercise, 15 min post-exercise, and 1,2,3, 4,7, and 10 days post-exercise.Results:No pre-test differences between HMB and CON groups were identified, and both performed a similar amount of eccentric work during the main eccentric exercise bout (p > .05). HMB supplementation had no effect on swelling, muscle soreness, or torque following the damaging eccentric exercise bout (p > .05).Conclusion:Compared to a placebo condition, short-term supplementation with 40mg/kg body weight/day of HMB had no beneficial effect on a range of symptoms associated with eccentric muscle damage. If HMB can produce an ergogenic response, a longer pre-exercise supplementation period may be necessary.

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