scholarly journals COMICS: a community property-based triangle motif clustering scheme

2019 ◽  
Vol 5 ◽  
pp. e180 ◽  
Author(s):  
Yufan Feng ◽  
Shuo Yu ◽  
Kaiyuan Zhang ◽  
Xiangli Li ◽  
Zhaolong Ning
Keyword(s):  
Large Scale ◽  
Statistical Data ◽  
Network Connectivity ◽  
Network Structures ◽  
Human Beings ◽  
Network Partition ◽  
Community Property ◽  
High Efficient ◽  
Motif Clustering ◽  
Large Scale Networks

With the development of science and technology, network scales of various fields have experienced an amazing growth. Networks in the fields of biology, economics and society contain rich hidden information of human beings in the form of connectivity structures. Network analysis is generally modeled as network partition and community detection problems. In this paper, we construct a community property-based triangle motif clustering scheme (COMICS) containing a series of high efficient graph partition procedures and triangle motif-based clustering techniques. In COMICS, four network cuttingconditionsare considered based on the network connectivity. We first divide the large-scale networks into many dense subgraphs under the cuttingconditionsbefore leveraging triangle motifs to refine and specify the partition results. To demonstrate the superiority of our method, we implement the experiments on three large-scale networks, including two co-authorship networks (the American Physical Society (APS) and the Microsoft Academic Graph (MAG)), and two social networks (Facebook and gemsec-Deezer networks). We then use two clustering metrics, compactness and separation, to illustrate the accuracy and runtime of clustering results. A case study is further carried out on APS and MAG data sets, in which we construct a connection between network structures and statistical data with triangle motifs. Results show that our method outperforms others in both runtime and accuracy, and the triangle motif structures can bridge network structures and statistical data in the academic collaboration area.

scholarly journals Effects of dopamine agonist treatment on resting-state network connectivity in Parkinson’s disease

2020 ◽  
Author(s):  
David M. Cole ◽  
Bahram Mohammadi ◽  
Maria Milenkova ◽  
Katja Kollewe ◽  
Christoph Schrader ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Dopamine Agonist ◽  
Resting State ◽  
Large Scale ◽  
Network Connectivity ◽  
Resting State Network ◽  
Large Scale Networks

ABSTRACTDopamine agonist (DA) medications commonly used to treat, or ‘normalise’, motor symptoms of Parkinson’s disease (PD) may lead to cognitive-neuropsychiatric side effects, such as increased impulsivity in decision-making. Subject-dependent variation in the neural response to dopamine modulation within cortico-basal ganglia circuitry is thought to play a key role in these latter, non-motor DA effects. This neuroimaging study combined resting-state functional magnetic resonance imaging (fMRI) with DA modification in patients with idiopathic PD, investigating whether brain ‘resting-state network’ (RSN) functional connectivity metrics identify disease-relevant effects of dopamine on systems-level neural processing. By comparing patients both ‘On’ and ‘Off’ their DA medications with age-matched, un-medicated healthy control subjects (HCs), we identified multiple non-normalising DA effects on frontal and basal ganglia RSN cortico-subcortical connectivity patterns in PD. Only a single isolated, potentially ‘normalising’, DA effect on RSN connectivity in sensori-motor systems was observed, within cerebro-cerebellar neurocircuitry. Impulsivity in reward-based decision-making was positively correlated with ventral striatal connectivity within basal ganglia circuitry in HCs, but not in PD patients. Overall, we provide brain systems-level evidence for anomalous DA effects in PD on large-scale networks supporting cognition and motivated behaviour. Moreover, findings suggest that dysfunctional striatal and basal ganglia signalling patterns in PD are compensated for by increased recruitment of other cortico-subcortical and cerebro-cerebellar systems.

scholarly journals Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chandra Sripada ◽  
Mike Angstadt ◽  
Aman Taxali ◽  
Daniel Kessler ◽  
Tristan Greathouse ◽  
...  
Keyword(s):  
Large Scale ◽  
Brain Connectivity ◽  
Network Connectivity ◽  
Quadrant Analysis ◽  
Default Network ◽  
General Factor ◽  
Multiple Control ◽  
Control Networks ◽  
Large Scale Networks ◽  
P Factor

AbstractConvergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); pPERMUTATION values < 0.05 FDR-corrected for multiple comparisons. Higher P factor scores were associated with hypoconnectivity within default network and hyperconnectivity between default network and multiple control networks. Among connections within these 28 significant cells, the P factor was predominantly associated with “attenuating” effects (67%; pPERMUTATION < 0.0002), i.e., reduced connectivity at neurotypically positive connections and increased connectivity at neurotypically negative connections. These results demonstrate that the general factor of psychopathology produces attenuating changes across multiple networks including default network, involved in spontaneous responses, and control networks involved in cognitive control. Moreover, they clarify mechanisms of transdiagnostic risk for psychopathology and invite further research into developmental causes of distributed attenuated connectivity.

scholarly journals Identifying and quantifying potential super-spreaders in social networks

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Dayong Zhang ◽  
Yang Wang ◽  
Zhaoxin Zhang
Keyword(s):  
Social Networks ◽  
Information Flow ◽  
Time Complexity ◽  
Large Scale ◽  
Network Connectivity ◽  
Sir Model ◽  
The Other ◽  
Nearest Neighbours ◽  
Large Scale Networks ◽  
Accuracy And Stability

Abstract Quantifying the nodal spreading abilities and identifying the potential influential spreaders has been one of the most engaging topics recently, which is essential and beneficial to facilitate information flow and ensure the stabilization operations of social networks. However, most of the existing algorithms just consider a fundamental quantification through combining a certain attribute of the nodes to measure the nodes’ importance. Moreover, reaching a balance between the accuracy and the simplicity of these algorithms is difficult. In order to accurately identify the potential super-spreaders, the CumulativeRank algorithm is proposed in the present study. This algorithm combines the local and global performances of nodes for measuring the nodal spreading abilities. In local performances, the proposed algorithm considers both the direct influence from the node’s neighbourhoods and the indirect influence from the nearest and the next nearest neighbours. On the other hand, in the global performances, the concept of the tenacity is introduced to assess the node’s prominent position in maintaining the network connectivity. Extensive experiments carried out with the Susceptible-Infected-Recovered (SIR) model on real-world social networks demonstrate the accuracy and stability of the proposed algorithm. Furthermore, the comparison of the proposed algorithm with the existing well-known algorithms shows that the proposed algorithm has lower time complexity and can be applicable to large-scale networks.

scholarly journals Targeted cortical reorganization using optogenetics in non-human primates

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Azadeh Yazdan-Shahmorad ◽  
Daniel B Silversmith ◽  
Viktor Kharazia ◽  
Philip N Sabes
Keyword(s):  
Large Scale ◽  
Network Connectivity ◽  
Cortical Reorganization ◽  
Strongly Correlated ◽  
Hebbian Plasticity ◽  
Two Measures ◽  
Evoked Activity ◽  
Large Scale Networks ◽  
Induced Changes ◽  
Stimulation Of

Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in two macaques. A large-scale optogenetic interface enabled simultaneous stimulation of excitatory neurons and electrocorticographic recording across primary somatosensory (S1) and motor (M1) cortex (Yazdan-Shahmorad et al., 2016). We tracked two measures of network connectivity, the network response to focal stimulation and the baseline coherence between pairs of electrodes; these were strongly correlated before stimulation. Within minutes, stimulation in S1 or M1 significantly strengthened the gross functional connectivity between these areas. At a finer scale, stimulation led to heterogeneous connectivity changes across the network. These changes reflected the correlations introduced by stimulation-evoked activity, consistent with Hebbian plasticity models. This work extends Hebbian plasticity models to large-scale circuits, with significant implications for stimulation-based neurorehabilitation.

Social inequality in the evolution of human societies

2019 ◽  
pp. 98-120
Author(s):  
Georgi Derluguian
Keyword(s):  
Social Inequality ◽  
Large Scale ◽  
Human Beings ◽  
Mass Violence ◽  
Public And Private ◽  
Tangible Assets ◽  
Transition To Agriculture ◽  
New Institutions ◽  
High Level ◽  
Political Economic

The author develops ideas about the origin of social inequality during the evolution of human societies and reflects on the possibilities of its overcoming. What makes human beings different from other primates is a high level of egalitarianism and altruism, which contributed to more successful adaptability of human collectives at early stages of the development of society. The transition to agriculture, coupled with substantially increasing population density, was marked by the emergence and institutionalisation of social inequality based on the inequality of tangible assets and symbolic wealth. Then, new institutions of warfare came into existence, and they were aimed at conquering and enslaving the neighbours engaged in productive labour. While exercising control over nature, people also established and strengthened their power over other people. Chiefdom as a new type of polity came into being. Elementary forms of power (political, economic and ideological) served as a basis for the formation of early states. The societies in those states were characterised by social inequality and cruelties, including slavery, mass violence and numerous victims. Nowadays, the old elementary forms of power that are inherent in personalistic chiefdom are still functioning along with modern institutions of public and private bureaucracy. This constitutes the key contradiction of our time, which is the juxtaposition of individual despotic power and public infrastructural one. However, society is evolving towards an ever more efficient combination of social initiatives with the sustainability and viability of large-scale organisations.

A Different Kind of Animal

2019 ◽  
Author(s):  
Robert Boyd
Keyword(s):  
Cognitive Ability ◽  
Cultural Adaptation ◽  
Dominant Species ◽  
Large Scale ◽  
Human Beings ◽  
Unique Combination ◽  
Essential Ingredient ◽  
Princeton University

Human beings have evolved to become the most dominant species on Earth. This astonishing transformation is usually explained in terms of cognitive ability—people are just smarter than all the rest. But this book argues that culture—our ability to learn from each other—has been the essential ingredient of our remarkable success. The book shows how a unique combination of cultural adaptation and large-scale cooperation has transformed our species and assured our survival—making us the different kind of animal we are today. The book is based on the Tanner Lectures delivered at Princeton University, featuring challenging responses across the chapters.

STUDY OF ENVIRONMENTAL AWARENESS AMONG SENIOR SECONDARY SCHOOL STUDENTS IN RELATION TO THEIR GENDER AND ACADEMIC STREAM

2015 ◽  
Vol 3 (2) ◽  
pp. 262-265
Author(s):  
Dr.Navdeep Kaur
Keyword(s):  
Environmental Education ◽  
Natural Resources ◽  
Large Scale ◽  
Human Life ◽  
Environmental Awareness ◽  
Human Beings ◽  
School Students ◽  
The Earth ◽  
Stages Of Learning ◽  
The Masses

Since its evolution environment has remained both a matter of awe and concern to man. The frontier attitude of the industrialized society towards nature has not only endangered the survival of all other life forms but also threatened the very existence of human life. The realization of such potential danger has necessitated the dissemination of knowledge and skill vis-a-vis environment protection at all stages of learning. Therefore, learners of all stages of learning need to be sensitized with a missionary zeal. This may ensure transformation of students into committed citizens for averting global environment crisis. The advancement of science and technology made the life more and more relaxed and man also became more and more ambitious. With such development, human dependence on environment increased. He consumed more resources and the effect of his activities on the environment became more and more detectable. Environment covers all the things present around the living beings and above the land, on the surface of the earth and under the earth. Environment indicates, in total, all of peripheral forces, pressures and circumstances, which affect the life, nature, behaviour, growth, development and maturation of living beings. Irrational exploitation (not utilization) of natural resources for our greed (not need) has endangered our survival, and incurred incalculable harm. Environmental Education is a science, a well-thought, permanent, lasting and integrated process of equipping learning experiences for getting awareness, knowledge, understanding, skills, values, technical expertise and involvement of learners with desirable attitudinal changes about their relationship with their natural and biophysical environment. Environmental Education is an organized effort to educate the masses about environment, its functions, need, importance, and especially how human beings can manage their behaviour in order to live in a sustainable manner.  The term 'environmental awareness' refers to creating general awareness of environmental issues, their causes by bringing about changes in perception, attitude, values and necessary skills to solve environment related problems. Moreover, it is the first step leading to the formation of responsible environmental behaviour (Stern, 2000). With the ever increasing development by modern man, large scale degradation of natural resources have been occurred, the public has to be educated about the fact that if we are degrading our environment we are actually harming ourselves. To encourage meaningful public participation and environment, it is necessary to create awareness about environment pollution and related adverse effects. This is the crucial time that environmental awareness and environmental sensitivity should be cultivated among the masses particularly among youths. For the awareness of society it is essential to work at a gross root level. So the whole society can work to save the environment.

Recent Advances in Heterostructured Photocatalysts for Degradation of Organic Pollutants.

2020 ◽  
Vol 17 ◽  
Author(s):  
Chen-Jing Sun ◽  
Li-Ping Zhao ◽  
Rui Wang
Keyword(s):  
Organic Pollutants ◽  
High Efficiency ◽  
Separation Efficiency ◽  
Organic Pollution ◽  
Utilization Rate ◽  
Type I ◽  
Human Beings ◽  
Global Challenge ◽  
Global Environmental ◽  
High Efficient

: With the development of industrialization, the global environmental pollution and energy crisis are becoming increasingly serious. Organic pollutants pose a serious health threat to human beings and other organisms. The removal of organic pollutants in environment has become a global challenge. The photocatalytic technology has been widely used in the degradation of organic pollutants with its characteristics of simple process, high efficiency, thorough degradation and no secondary pollution. However, the single photocatalyst represented by TiO2 has disadvantages of low light utilization rate and high recombination rate of photocarriers. Building heterojunction is considered one of the most effective methods to enhance the photocatalytic performance of single photocatalyst, which can improve the separation efficiency of photocarriers and utilization of visible light. The classical heterojunction can be divided into four different cases: type I, typeⅡ, p–n heterojunctions and Z-scheme junction. In this paper, the recent progress in the treatment of organic pollution by heterostructure photocatalysts is summarized and the mechanism of heterostructure photocatalysts for the treatment of organic pollutants is reviewed. It is expected that this paper can deepen the understanding of heterostructure photocatalysts and provide guidance for high efficient photocatalytic degradation of organic pollutants in the future.

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