scholarly journals What is the relationship between survival motor neuron expression and rat spinal cord development?

2015 ◽  
Author(s):  
S Almutairi ◽  
F Alhumaid ◽  
P Roach ◽  
MA Gates ◽  
HR Fuller
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Survival Motor Neuron ◽  
Rat Spinal Cord ◽  
Spinal Cord Development ◽  
The Relationship

An Early Developmental Marker for Radial Glia in Rat Spinal Cord

1996 ◽  
Vol 54 ◽  
pp. 36-37
Author(s):  
V. Kriho ◽  
H.-Y. Yang ◽  
C.-M. Lue ◽  
N. Lieska ◽  
G. D. Pappas
Keyword(s):  
Spinal Cord ◽  
Intermediate Filament ◽  
Radial Glia ◽  
Rat Spinal Cord ◽  
Future Studies ◽  
Spinal Cord Development ◽  
Median Septum ◽  
Differentiation Marker ◽  
Early Developmental ◽  
Developing Rat

Radial glia have been classically defined as those early glial cells that radially span their thin processes from the ventricular to the pial surfaces in the developing central nervous system. These radial glia constitute a transient cell population, disappearing, for the most part, by the end of the period of neuronal migration. Traditionally, it has been difficult to definitively identify these cells because the principal criteria available were morphologic only.Using immunofluorescence microscopy, we have previously defined a phenotype for radial glia in rat spinal cord based upon the sequential expression of vimentin, glial fibrillary acidic protein and an intermediate filament-associated protein, IFAP-70/280kD. We report here the application of another intermediate filament-associated protein, IFAP-300kD, originally identified in BHK-21 cells, to the immunofluorescence study of radial glia in the developing rat spinal cord.Results showed that IFAP-300kD appeared very early in rat spinal cord development. In fact by embryonic day 13, IFAP-300kD immunoreactivity was already at its peak and was observed in most of the radial glia which span the spinal cord from the ventricular to the subpial surfaces (Fig. 1). Interestingly, from this time, IFAP-300kD immunoreactivity diminished rapidly in a dorsal to ventral manner, so that by embryonic day 16 it was detectable only in the maturing macroglial cells in the marginal zone of the spinal cord and the dorsal median septum (Fig. 2). By birth, the spinal cord was essentially immuno-negative for this IFAP. Thus, IFAP-300kD appears to be another differentiation marker available for future studies of gliogenesis, especially for the early stages of radial glia differentiation.

Red nucleus projections to distinct motor neuron pools in the rat spinal cord

2002 ◽  
Vol 448 (4) ◽  
pp. 349-359 ◽  
Author(s):  
Martin Küchler ◽  
Karim Fouad ◽  
Oliver Weinmann ◽  
Martin E. Schwab ◽  
Olivier Raineteau
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Red Nucleus ◽  
Rat Spinal Cord

scholarly journals Isoflurane, but Not the Nonimmobilizers F6 and F8, Inhibits Rat Spinal Cord Motor Neuron CaV1 Calcium Currents

2016 ◽  
Vol 122 (3) ◽  
pp. 730-737 ◽  
Author(s):  
Esperanza Recio-Pinto ◽  
Jose V. Montoya-Gacharna ◽  
Fang Xu ◽  
Thomas J. J. Blanck
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Calcium Currents ◽  
Rat Spinal Cord ◽  
Spinal Cord Motor Neuron

scholarly journals Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro

2013 ◽  
Vol 4 (6) ◽  
pp. e686-e686 ◽  
Author(s):  
A Garcera ◽  
N Bahi ◽  
A Periyakaruppiah ◽  
S Arumugam ◽  
R M Soler
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Survival Motor Neuron ◽  
Survival Motor Neuron Protein ◽  
Motor Neuron Protein ◽  
Protein Reduction

Correlation of Survival Motor Neuron Expression in Leukocytes and Spinal Cord in Spinal Muscular Atrophy

2009 ◽  
Vol 154 (2) ◽  
pp. 303-305 ◽  
Author(s):  
Li-Kai Tsai ◽  
Chih-Chao Yang ◽  
Chen-Hung Ting ◽  
Yi-Ning Su ◽  
Wuh-Liang Hwu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Muscular Atrophy ◽  
Motor Neuron ◽  
Muscular Atrophy ◽  
Survival Motor Neuron
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