scholarly journals Apoptotic development in pathological muscle damage in a time course study of pressure-induced deep tissue injury

2010 ◽  
Vol 59 (1) ◽  
pp. 70-70
Author(s):  
Teng BT ◽  
Tam EW ◽  
Benzie IF ◽  
Siu PM
Keyword(s):  
Muscle Damage ◽  
Time Course ◽  
Tissue Injury ◽  
Deep Tissue ◽  
Deep Tissue Injury ◽  
Time Course Study

Serum and Urine Biomarker Elevation Indicating the Onset of Deep Tissue Injury as Examined on a Rat Model

2010 ◽  
Author(s):  
Mohsen Makhsous ◽  
Atek Pandya ◽  
Mauli Modi ◽  
Briana Reprogle ◽  
Christopher C. Chadwick ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Rat Model ◽  
Tissue Injury ◽  
Muscle Layer ◽  
Release Time ◽  
Deep Tissue ◽  
Fatty Acid Binding ◽  
Deep Tissue Injury ◽  
Serum And Urine

Deep tissue injury (DTI) is a serious pressure ulcer (PU) which initiates in deep tissue, mainly muscle, and progresses rapidly to a full-thickness wound [1, 2]. Therefore, an early indication should help in increasing awareness and providing prompt intervention to prevent it from progressing to an open wound, which is susceptible to infection and typically needs prolonged and aggressive care. However, the diagnosis of DTI is currently still vague at best[2] with only subjective tools. This situation calls for tools for objectively sensing the tissue changes while the skin is still intact, to allow development of evidence-based protocols for early diagnosis and treatment. Since DTI initiates from deep muscle layer around a bony prominence, a tool that sensitive to muscle damage may have the potential to objectively sense the onset of a DTI in clinical application. A number of molecular biomarkers have been reported in the literature as suitable for indicating muscle damage. Some of the most promising biomarkers are myoglobin and heart-type fatty acid binding protein (H-FABP). Myoglobin and H-FABP are two relatively small muscle proteins that show a very fast release time after skeletal muscle damage/necrosis when no myocardial infarction or damage is present; therefore, they may be used to identify skeletal muscle injury in DTI formation. The objective of this study was to initially test whether myoglobin and H-FABP in serum and urine respond quickly to pressure induced deep tissue injury on a rat model. It is expected that knowledge gained from this study may lead to a promising new methodology to sense the visually invisible DTI.

Modelling the effect of repositioning on the evolution of skeletal muscle damage in deep tissue injury

2012 ◽  
Vol 12 (2) ◽  
pp. 267-279 ◽  
Author(s):  
Jan Demol ◽  
Dorien Van Deun ◽  
Bart Haex ◽  
Hans Van Oosterwyck ◽  
Jos Vander Sloten
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Tissue Injury ◽  
Deep Tissue ◽  
Deep Tissue Injury ◽  
Skeletal Muscle Damage

Healing effects of curcumin nanoparticles in deep tissue injury mouse model.

2020 ◽  
Vol 18 ◽  
Author(s):  
Zirui Zhang ◽  
Shangcong Han ◽  
Panpan Liu ◽  
Xu Yang ◽  
Jing Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mrna Expression ◽  
Tissue Injury ◽  
Inflammatory Cells ◽  
Pcr Analysis ◽  
Protective Effects ◽  
Deep Tissue ◽  
Deep Tissue Injury

Background: Chronic inflammation and lack of angiogenesis are the important pathological mechanisms in deep tissue injury (DTI). Curcumin is a well-known anti-inflammatory and antioxidant agent. However, curcumin is unstable under acidic and alkaline conditions, and can be rapidly metabolized and excreted in the bile, which shortens its bioactivity and efficacy. Objective: This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles (CPNPs) and to elucidate the protective effects and underlying mechanisms of wound healing in DTI models. Methods: CPNPs were evaluated for particle size, biocompatibility, in vitro drug release and their effect on in vivo wound healing. Results : The results of in vivo wound closure analysis revealed that CPNP treatments significantly improved wound contraction rates (p<0.01) at a faster rate than other three treatment groups. H&E staining revealed that CPNP treatments resulted in complete epithelialization and thick granulation tissue formation, whereas control groups resulted in a lack of compact epithelialization and persistence of inflammatory cells within the wound sites. Quantitative real-time PCR analysis showed that treatment with CPNPs suppressed IL-6 and TNF-α mRNA expression, and up-regulated TGF-β, VEGF-A and IL-10 mRNA expression. Western blot analysis showed up-regulated protein expression of TGF-β, VEGF-A and phosphorylatedSTAT3. Conclusion: Our results showed that CPNPs enhanced wound healing in DTI models, through modulation of the JAK2/STAT3 signalling pathway and subsequent upregulation of pro-healing factors.

Diffusion of water in skeletal muscle tissue is not influenced by compression in a rat model of deep tissue injury

2010 ◽  
Vol 43 (3) ◽  
pp. 570-575 ◽  
Author(s):  
Bastiaan J. van Nierop ◽  
Anke Stekelenburg ◽  
Sandra Loerakker ◽  
Cees W. Oomens ◽  
Dan Bader ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
Rat Model ◽  
Tissue Injury ◽  
Skeletal Muscle Tissue ◽  
Deep Tissue ◽  
Deep Tissue Injury

Evaluation of infrared technology to detect category I and suspected deep tissue injury in hospitalised patients

2019 ◽  
Vol 28 (Sup12) ◽  
pp. S9-S16
Author(s):  
Fazila Abu Bakar Aloweni ◽  
Shin Yuh Ang ◽  
Yee Yee Chang ◽  
Xin Ping Ng ◽  
Kai Yunn Teo ◽  
...  
Keyword(s):  
Skin Temperature ◽  
Infrared Thermography ◽  
Tissue Injury ◽  
Mean Difference ◽  
Deep Tissue ◽  
Thermal Images ◽  
Deep Tissue Injury ◽  
Hospitalised Patients ◽  
Significant Difference ◽  
The Mean

Objective: To evaluate the use of an infrared thermography device in assessing skin temperature among category I pressure ulcer (PU) and/or suspected deep tissue injuries (SDTI) with intact skin. Methods: An observational cross-sectional study design was used. Adult inpatients (cases) who had a category I PU or suspected deep tissue injury (skin intact) on the sacral or heel during the study period (March to April 2018) were recruited. Patients without a PU were also recruited to act as control. Thermal images of the patient's PU site and non-PU site were taken within 24 hours of PU occurrence. Thermal images of the control patients (no PU) were also taken. Each PU case was matched to three control patients in terms of age, gender, race and anatomical sites. All thermal images were taken using a portable CAT S60 Thermal Imaging Rugged Smartphone (Caterpillar Inc., US) that provided readings of the skin temperature in degrees Celsius. Results: A total of 17 cases and 51 controls were recruited. Among the cases, the mean difference in skin temperature between the PU site (mean: 31.14°C; standard deviation [SD]: 1.54) and control site within the cases (mean: 28.93°C; SD: 3.47) was significant (difference: 2.21±3.66°C; p=0·024). When comparing between all cases and controls, the mean temperature difference was non-significant. When comparing between the category I PU and suspected deep pressure injury cases, the mean difference was also non-significant. Conclusion: Using infrared thermography technology at the bedside to measure skin temperature will support the clinical diagnosis of patients with skin types I to III. However, there is a need for a more accurate and objective measurement to identify and diagnose early category I PU or suspected deep tissue injury in adult patients with darker skin types 4 and above, enabling early initiation of preventive measures in the hospital acute care setting.

scholarly journals Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Xu Yang ◽  
Jing-Lin Guo ◽  
Jing Han ◽  
Rui-Juan Si ◽  
Pan-Pan Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tissue Injury ◽  
Deep Tissue ◽  
Chitosan Hydrogel ◽  
Deep Tissue Injury

scholarly journals Magnetic resonance elastography of skeletal muscle deep tissue injury

2019 ◽  
Vol 32 (6) ◽  
pp. e4087 ◽  
Author(s):  
Jules L. Nelissen ◽  
Ralph Sinkus ◽  
Klaas Nicolay ◽  
Aart J. Nederveen ◽  
Cees W.J. Oomens ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Magnetic Resonance ◽  
Tissue Injury ◽  
Magnetic Resonance Elastography ◽  
Deep Tissue ◽  
Deep Tissue Injury

Suspected Deep Tissue Injury Evaluated by North Carolina WOC Nurses

2011 ◽  
Vol 38 (6) ◽  
pp. 655-660 ◽  
Author(s):  
Leanne Richbourg ◽  
June Smith ◽  
Susan Dunzweiler
Keyword(s):  
North Carolina ◽  
Tissue Injury ◽  
Deep Tissue ◽  
Deep Tissue Injury
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