scholarly journals Synthesis, Spectral and Antimicrobial Studies of Some O-Vanillin-2-aminopyridine Schiff Base Complexes of Organyltellurium(IV)

2018 ◽  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Antimicrobial Studies

In Methanolic Solvent Synthesis of New MnII, CoII, NiII and CuII Schiff Base of Aromatic β Amino Acids: Spectroscopic, Thermal, Molecular Docking and Antimicrobial Studies

2020 ◽  
Vol 12 (8) ◽  
pp. 1137-1148 ◽  
Author(s):  
Asma S. Al-Wasidi ◽  
Nawal M. Al-Jafshar ◽  
Amal M. Al-Anazi ◽  
Moamen S. Refat ◽  
Nashwa M. El-Metwaly ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Amino Acid ◽  
Benzoic Acid ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Proton Nuclear Magnetic Resonance ◽  
Antimicrobial Studies ◽  
Amino Benzoic Acid

In this article, four new Schiff base complexes of Mn(II), Co(II), Ni(II) and Cu(II) complexes have been synthesized with two different compositions as [M(L)2Cl2] · nH2O and [M(L)2(H2O)2]Cl2 · nH2O [where L1 = benzoin-o-amino benzoic acid (aromatic β amino acid) and L2 = benzoin bromo-o-amino benzoic acid (aromatic β amino acid); M = MnII, CoII, NiII and CuII; n = 1, 2 and 4]. These Schiff base complexes were discussed by many tool of analyses like elemental analysis, magnetic susceptibility, molar conductance, mass spectra, infrared spectra "IR," proton nuclear magnetic resonance "1H-NMR," electronic spectral and thermogravimetric analysis (TG/DTG). These complexes have an electrolytic nature within range of 78–174 Ω1 cm–1 mol –1 based on conductance measurements. Magnetic moment and electronic spectral results deduced that the geometry of Mn2+, Co2+ and Ni2+ and Cu2+ complexes has an octahedral configuration. The number of coordinated and uncoordinated water molecules for the synthesized complexes were calculated based on the thermal analysis technique. The kinetic thermodynamic data were estimated by using commonly integral equations of Horowitz-Metzger (HM) and Coats-Redfern (CR). In vitro the antimicrobial activity of both free L1 and L2 ligands in comparable with their metal complexes were evaluated. This study was strengthen by molecular docking against three protein receptors, which attributing to selected organisms already used in vitro study.

Spectrometric, catalytic, and antimicrobial studies of mononuclear Ru(III) Schiff-base complexes

2009 ◽  
Vol 62 (21) ◽  
pp. 3532-3543 ◽  
Author(s):  
N. Sathya ◽  
P. Muthusamy ◽  
N. Padmapriya ◽  
G. Raja ◽  
K. Deivasigamani ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Antimicrobial Studies

Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base

2010 ◽  
Vol 64 (3) ◽  
Author(s):  
Natarajan Raman ◽  
Ramaraj Jeyamurugan ◽  
Mariyyappan Subbulakshmi ◽  
Raja Boominathan ◽  
Chithu Yuvarajan
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Dna Cleavage ◽  
Double Helix ◽  
Structural Features ◽  
Schiff Base Complexes ◽  
Diffusion Method ◽  
Spectral Techniques ◽  
Antimicrobial Studies

AbstractA novel series of Co(II), Ni(II), Cu(II), Zn(II), and VO(IV) complexes has been synthesized from the Schiff base derived from 4-[(3,4-dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one and 1,2-diaminobenzene. Structural features were determined by analytical and spectral techniques. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods and viscosity measurements. Experimental results indicate that the complexes are able to form adducts with DNA and to distort the double helix by changing the base stacking. Lower DNA affinity of the VO(IV) complex is caused by the change of coordination geometry by the vanadyl ion resulting in a somewhat unfavorable configuration for the DNA binding. Oxidative DNA cleavage activities of the complexes were studied with supercoiled (SC) pUC19 DNA using gel electrophoresis; the mechanism studies revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes. The in vitro antimicrobial screening effects of the investigated compounds were monitored by the disc diffusion method. The synthesized Schiff base complexes exhibit higher antimicrobial activity than the respective free Schiff base.

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