scholarly journals Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

2017 ◽  
Vol 6 (4) ◽  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Nuclease Activity ◽  
Metal Organic ◽  
Chemical Nuclease ◽  
Antimicrobial Evaluation

Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Drug Research ◽  
2021 ◽  
Author(s):  
Preeti Sharma ◽  
Varun Kumar Singh ◽  
Gajendra Kumar
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Antimicrobial Evaluation ◽  
Aspergillus Sp ◽  
Bacteria And Fungi

AbstractSchiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70 oC. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as [M(C34H32N8O4)X]X2. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. [Cr(C34H32N8O4)OAc](OAc)2 shows best antimicrobial activity against all the pathogens.

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