scholarly journals Utilitization of Charge Transfer Complexation Reaction for the Spectrophotometric Determination of Vardenafil HCl and Yohimbin HCl in Pharmaceutical Formulations

2016 ◽  
Keyword(s):  
Charge Transfer ◽  
Spectrophotometric Determination ◽  
Pharmaceutical Formulations ◽  
Complexation Reaction ◽  
Charge Transfer Complexation

scholarly journals Utility of σ and π-Acceptors for the Spectrophotometric Determination of Gemifloxacin Mesylate in Pharmaceutical Formulations

2008 ◽  
Vol 5 (3) ◽  
pp. 493-498 ◽  
Author(s):  
Marothu Vamsi Krishna ◽  
Dannana Gowri Sankar
Keyword(s):  
Charge Transfer ◽  
Good Accuracy ◽  
Pharmaceutical Formulations ◽  
Charge Transfer Complexes ◽  
Complexation Reaction ◽  
Experimental Conditions ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision ◽  
Charge Transfer Complexation

In this study, four simple, fast, accurate and sensitive spectrophotometric methods have been developed for the determination of gemifloxacin mesylate in pharmaceutical formulations. The methods are based on the charge transfer complexation reaction of the drug as n-electron donor with sigma (σ)-acceptor iodine, and thepi(π)-acceptors 2, 3-dichloro-5, 6-dicyano-p-benzoquinone (DDQ)-7,7,8,8-tetra cyanoquinodimethane (TCNQ) and tetracyanoethylene (TCNE). The obtained charge transfer complexes were measured at 290nm for iodine (in 1, 2-dichloro ethane), at 470, 840 and 420 nm for DDQ, TCNQ and TCNE (in acetonitrile), respectively. Optimization of different experimental conditions is described. Beer's law is obeyed in the concentration range of 6-30, 2-10, 2.5-12.5 and 1-5 μg mL−1for iodine, DDQ, TCNQ and TCNE methods, respectively. The proposed methods were applied successfully to the determination of GFX in pharmaceutical formulations with good accuracy and precision.

scholarly journals Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents

2010 ◽  
Vol 7 (4) ◽  
pp. 1507-1513 ◽  
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
V. Nagalakshmi ◽  
B. B. V. Sailaja
Keyword(s):  
Charge Transfer ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Spectrophotometric Methods ◽  
Oxidative Coupling Reaction ◽  
Charge Transfer Complexation

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3-methyl-2-benzathiazolinone hydrazone (MBTH) in presence of Ce(IV). The formation of oxidative coupling product with 4-amino phenazone (4-AP) in presence of K3Fe(CN)6is incorporated in method B. Precipitation/charge transfer complex formation of the PYRA with tannic acid (TA)/Metol-Cr(VI) in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope (b), intercept (a) and correlation coefficient (r) and standard error of estimation (Se) for each system. Determination of pyrilamine in bulk form and in pharmaceutical formulations were also incorporated.

Spectrophotometric determination of some corticosteroid drugs through charge-transfer complexation

The Analyst ◽  
1984 ◽  
Vol 109 (11) ◽  
pp. 1417 ◽  
Author(s):  
Magda M. Ayad ◽  
Saied Belal ◽  
Sobhi M. El Adl ◽  
Afaf A. Al Kheir
Keyword(s):  
Charge Transfer ◽  
Spectrophotometric Determination ◽  
Corticosteroid Drugs ◽  
Charge Transfer Complexation
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