scholarly journals Microwave Assisted Synthesis, Molecular Docking and HIV-1 gp120 – CD4 Binding Inhibition Studies of Symmetrical N, N'-disubstituted Urea/Thiourea

2014 ◽  
Keyword(s):  
Molecular Docking ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Binding Inhibition ◽  
Inhibition Studies ◽  
Hiv 1

ChemInform Abstract: Microwave-Assisted Synthesis, Molecular Docking and Antitubercular Activity of 1,2,3,4-Tetrahydropyrimidine-5-carbonitrile Derivatives (IV)

ChemInform ◽  
2013 ◽  
Vol 44 (17) ◽  
pp. no-no
Author(s):  
Sahoo Biswa Mohan ◽  
B. V. V. Ravi Kumar ◽  
S. C. Dinda ◽  
D. Naik ◽  
S. Prabu Seenivasan ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antitubercular Activity ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

New chalcones and thiopyrimidine analogues derived from mefenamic acid: microwave-assisted synthesis, anti-HIV activity and cytotoxicity as antileukemic agents

2017 ◽  
Vol 72 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Hanan A. Al-Hazam ◽  
Zeki A. Al-Shamkani ◽  
Najim A. Al-Masoudi ◽  
Bahjat A. Saeed ◽  
Christophe Pannecouque
Keyword(s):  
Mefenamic Acid ◽  
Leukemia Cells ◽  
Basic Medium ◽  
Microwave Assisted Synthesis ◽  
Schmidt Reaction ◽  
Microwave Assisted ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

AbstractThe development of new HIV non-nucleoside reverse transcriptase inhibitors offers the possibility of generating structures of increased potency. To this end, coupling of mefenamic acid (4) with 4-amino-acetophenone (6) in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine (DMAP) reagents afforded 4-(acetyphenyl)-2-((2,3-dimethylphenyl)amino)benzamide (7). Analogously, treatment of mefenamyl chloride (5) prepared from 4 with 6 under microwave irradiation (MWI) afforded 7. A new series of substituted chalconyl-incorporated amide derivatives of mefenamic acid 8–13 were synthesized from condensation of 7 with various substituted benzaldehydes via the Claisen–Schmidt reaction. Treatment of 8 and 11 with thiourea in a basic medium afforded the thiopyrimidine analogues 14 and 15, respectively. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 11 showed cytotoxicity values of 2.17 and 2.06 μm, respectively, against mock-infected MT-4 cells (C type adult T leukemia cells), which considered to be promising antileukemic agents.

Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl,1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones

2016 ◽  
Vol 25 (3) ◽  
pp. 501-514 ◽  
Author(s):  
Dongamanti Ashok ◽  
Kavitha Rangu ◽  
Velagapuri Hanumantha Rao ◽  
Srinivas Gundu ◽  
Ballu Srilata ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Docking ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted

Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study

2019 ◽  
Vol 1179 ◽  
pp. 401-410 ◽  
Author(s):  
Neelam P. Prajapati ◽  
Kinjal D. Patel ◽  
Rajesh H. Vekariya ◽  
Hitesh D. Patel ◽  
Dhanaji P. Rajani
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Biological Evaluation ◽  
Microwave Assisted Synthesis ◽  
Molecular Docking Study ◽  
Microwave Assisted
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