PARTIAL PROTECTION IN BALB/C HOUSE MICE (MUS MUSCULUS) AND ROCKY MOUNTAIN ELK (CERVUS CANADENSIS) AFTER VACCINATION WITH A KILLED, MUCOSALLY DELIVERED BRUCELLA ABORTUS VACCINE

2019 ◽  
Vol 55 (4) ◽  
pp. 794
Author(s):  
Jack Rhyan ◽  
Pauline Nol ◽  
Morgan Wehtje ◽  
Angela Bosco-Lauth ◽  
Nicole Marlenee ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Brucella Abortus ◽  
Rocky Mountain ◽  
House Mice ◽  
Partial Protection ◽  
Cervus Canadensis ◽  
Rocky Mountain Elk

scholarly journals VALIDATION OF A BRUCELLA ABORTUS COMPETITIVE ENZYME-LINKED IMMUNOSORBENT ASSAY FOR USE IN ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI)

2003 ◽  
Vol 39 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Clayton K. Van Houten ◽  
E. Lee Belden ◽  
Terry J. Kreeger ◽  
Elizabeth S. Williams ◽  
William H. Edwards ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Cervus Elaphus ◽  
Brucella Abortus ◽  
Rocky Mountain ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cervus Elaphus Nelsoni ◽  
Rocky Mountain Elk

scholarly journals A pseudomolecule assembly of the Rocky Mountain elk genome reveals putative immune system gene loss near chromosomal fissions

2020 ◽  
Author(s):  
Rick E Masonbrink ◽  
David Alt ◽  
Darrel O. Bayles ◽  
Paola Boggiatto ◽  
William Edwards ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Genome Assembly ◽  
Rocky Mountain ◽  
Bacterial Disease ◽  
Putative Gene ◽  
Economic Implications ◽  
Cervus Canadensis ◽  
Gene Models ◽  
Rocky Mountain Elk

AbstractRocky Mountain elk (Cervus canadensis) is a major reservoir for Brucella abortus in the Greater Yellowstone area, which has significant economic implications to the cattle industry. Vaccination attempts against intracellular bacterial diseases in elk populations have not been successful due to a negligible adaptive cellular immune response. A lack of genomic resources has impeded attempts to better understand why vaccination does not induce protective immunity. To overcome this limitation, PacBio, Illumina, and HiC sequencing with a total of 686-fold coverage was used to assemble the elk genome into 35 pseudomolecules. A robust gene annotation was generated resulting in 18,013 gene models and 33,422 mRNAs. The accuracy of the assembly was assessed using synteny to the red deer and cattle genomes identifying several chromosomal rearrangements, fusions and fissions. Because this genome assembly and annotation provide a foundation for genome-enabled exploration of Cervus species, we demonstrate its utility by exploring the conservation of immune system-related genes. We conclude by comparing cattle immune system-related genes to the elk genome, revealing nine putative gene losses in elk.Author SummaryBrucellosis, also known as contagious abortion, is a bacterial disease that commonly affects livestock and remains prevalent in Rocky Mountain elk (Cervus canadensis). Since the 1920’s the USDA has led a program to eradicate Brucellosis from cattle, yet wild Rocky Mountain elk continue to be a source of transmission. Attempts to vaccinate wild elk herds have been unsuccessful, due to a poor and short-lived immune response. To investigate the genetic basis for this inherent difference, we created the first genome and annotation for the Rocky Mountain elk. This genome assembly is of the highest quality and contains single linear sequences for all 35 chromosomes. In order to generate gene models, an array of RNA-Seq data and proteins from many different organ tissues and cells were used in gene prediction software. Specifically, we compare cattle immune system genes with the Rocky Mountain elk, revealing the putative loss of nine immune-system related genes in elk.

scholarly journals Detection of two dissimilar chronic wasting disease isolates in two captive Rocky Mountain elk (Cervus canadensis) herds

Prion ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 207-215
Author(s):  
Tracy A. Nichols ◽  
Eric M. Nicholson ◽  
Yihui Liu ◽  
Wanyun Tao ◽  
Terry R. Spraker ◽  
...  
Keyword(s):  
Chronic Wasting Disease ◽  
Rocky Mountain ◽  
Wasting Disease ◽  
Cervus Canadensis ◽  
Rocky Mountain Elk

EFFECTS OF BRUCELLOSIS SEROLOGIC STATUS ON PHYSIOLOGY AND BEHAVIOR OF ROCKY MOUNTAIN ELK (CERVUS CANADENSIS NELSONI) IN SOUTHWESTERN MONTANA, USA

2019 ◽  
Vol 55 (2) ◽  
pp. 304 ◽  
Author(s):  
Anni Yang ◽  
Juan Pablo Gomez ◽  
Catherine G. Haase ◽  
Kelly M. Proffitt ◽  
Jason K. Blackburn
Keyword(s):  
Rocky Mountain ◽  
Southwestern Montana ◽  
Cervus Canadensis ◽  
Rocky Mountain Elk ◽  
And Behavior

NINETEEN ROCKY MOUNTAIN ELK (CERVUS CANADENSIS NELSONI) KILLED IN AN AVALANCHE IN THE THREE SISTERS WILDERNESS

2021 ◽  
Vol 102 (3) ◽  
Author(s):  
Mike J Skladanowski ◽  
Emily C Weidner ◽  
Jamie L Bowles ◽  
Mark Hebblewhite
Keyword(s):  
Rocky Mountain ◽  
Cervus Canadensis ◽  
Rocky Mountain Elk ◽  
Three Sisters

The contribution of raptorial birds to patterning in small mammal assemblages

Paleobiology ◽  
1988 ◽  
Vol 14 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Rob Hoffman
Keyword(s):  
Small Mammal ◽  
Mus Musculus ◽  
House Mice ◽  
Potential Contribution ◽  
Quantitative Analyses ◽  
Interspecies Variability ◽  
Fossil Assemblages ◽  
Mammal Assemblages

Seven taxa of raptorial birds were experimentally fed a controlled sample of 50 house mice (Mus musculus). Bones recovered from the pellets were examined for interspecies variability in preservation to assess the potential contribution of specific raptors to patterning in fossil assemblages. Quantitative analyses demonstrate that patterns in bone fragmentation may assist in the identification of particular raptor species as depositional agents in small mammal assemblages.

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

scholarly journals Brucellosis in Captive Rocky Mountain Bighorn Sheep (Ovis canadensis) Caused by Brucella abortus Biovar 4

2004 ◽  
Vol 40 (2) ◽  
pp. 311-315 ◽  
Author(s):  
Terry J. Kreeger ◽  
Walter E. Cook ◽  
William H. Edwards ◽  
Todd Cornish
Keyword(s):  
Brucella Abortus ◽  
Rocky Mountain ◽  
Bighorn Sheep ◽  
Ovis Canadensis
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